1',2',3',4',5',6'-hexahydro-[2,4']bipyridinyl-5-carboxylic acid amide | 845788-62-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 1',2',3',4',5',6'-hexahydro-[2,4']bipyridinyl-5-carboxylic acid amide
• 英文别名: 1',2',3',4',5',6'-hexahydro-[2,4']bipyridyl-5-carboxylic acid amide；6-(piperidin-4-yl)nicotinamide；6-(4-Piperidinyl)-3-pyridinecarboxamide；6-piperidin-4-ylpyridine-3-carboxamide
• CAS: 845788-62-7
• 化学式: C₁₁H₁₅N₃O
• 分子量: 205.26
• InChiKey: ANELDFQWTABRKD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.1
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  68
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• Pyridyltetrahydropyridines and pyridylpiperidines and method of manufacturing them
  申请人：Kuwabara Hirokazu

  公开号：US20070093528A1

  公开（公告）日：2007-04-26

  The present invention provides pyridine derivatives useful as intermediates of drugs and agricultural chemicals, electrophotographic receptors, dyes and so on. More specifically, the invention relates to novel pyridyltetrahydropyridines and novel pyridylpiperidines, and further to a method of manufacturing pyridine derivatives through reaction between bipyridine derivatives and benzyl halide or benzyloxycarbonyl halide and subsequent reduction of the resultant reaction products with the aid of palladium catalysts, platinum catalysts, ruthenium catalysts or rhodium catalysts.

  本发明提供了吡啶衍生物，作为药物和农业化学品的中间体，电子照相感受器，染料等。更具体地，本发明涉及新型吡啶基四氢吡啶和新型吡啶基哌啶，以及通过双吡啶衍生物和苯甲醰或苄氧羰基卤化物反应，并在钯催化剂、铂催化剂、钌催化剂或铑催化剂的帮助下还原所得反应产物的吡啶衍生物制备方法。
• Pyridyltetrahydropyridines and Pyridylpiperidines, and Method of Manufacturing Them
  申请人：Kuwabara Hirokazu

  公开号：US20100029947A1

  公开（公告）日：2010-02-04

  The present invention provides pyridine derivatives useful as intermediates of drugs and agricultural chemicals, electrophotographic receptors, dyes and so on. More specifically, the invention relates to novel pyridyltetrahydropyridines and novel pyridylpiperidines, and further to a method of manufacturing pyridine derivatives through reaction between bipyridine derivatives and benzyl halide or benzyloxycarbonyl halide and subsequent reduction of the resultant reaction products with the aid of palladium catalysts, platinum catalysts, ruthenium catalysts or rhodium catalysts.

  本发明提供了吡啶衍生物，可用作药物和农业化学品，电子照相受体，染料等的中间体。更具体地说，本发明涉及新型吡啶基四氢吡啶和新型吡啶基哌啶，以及通过双吡啶衍生物和苯甲醰或苄氧羰基卤化物的反应制备吡啶衍生物的方法，并借助钯催化剂、铂催化剂、钌催化剂或铑催化剂还原所得反应产物的方法。
• US7632950B2
  申请人：——

  公开号：US7632950B2

  公开（公告）日：2009-12-15
• US8530662B2
  申请人：——

  公开号：US8530662B2

  公开（公告）日：2013-09-10