(+/-)-7-[(1-benzenesulfonyl-5-chloroindol-2-yl)sulfonyl]tetrahydro-8a-(N,N-dimethylaminomethyl)-spiro[5H-oxazolo[3,2-a]pyrazine-2(3H),4'-piperidin]-5-one | 911834-58-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 氮杂螺癸烷衍生物
• 英文名称: (+/-)-7-[(1-benzenesulfonyl-5-chloroindol-2-yl)sulfonyl]tetrahydro-8a-(N,N-dimethylaminomethyl)-spiro[5H-oxazolo[3,2-a]pyrazine-2(3H),4'-piperidin]-5-one
• 英文别名: 7-[1-(benzenesulfonyl)-5-chloroindol-2-yl]sulfonyl-8a-[(dimethylamino)methyl]spiro[6,8-dihydro-3H-[1,3]oxazolo[3,2-a]pyrazine-2,4'-piperidine]-5-one
• CAS: 911834-58-7
• 化学式: C₂₇H₃₂ClN₅O₆S₂
• 分子量: 622.166
• InChiKey: KCEQVUOUFDOPLR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  41
• 可旋转键数：
  6
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  138
• 氢给体数：
  1
• 氢受体数：
  9

文献信息

• Tricyclic Spiro Compound Comprising Acyl Group Bound to Nitrogen Atom in the Ring
  申请人：Nishida Hidemitsu

  公开号：US20090076015A1

  公开（公告）日：2009-03-19

  It is intended to provide an anticoagulant that has an extremely excellent FXa inhibitory action and an extremely weak hERG channel inhibitory action and can be orally administered, which is a compound represented by the following formula (I) or a pharmaceutically acceptable salt thereof.

  该文旨在提供一种极为优异的FXa抑制剂，具有极弱的hERG通道抑制作用，并可口服，该化合物由以下公式(I)所代表，或其药学上可接受的盐。
• TRICYCLIC SPIRO COMPOUND COMPRISING ACYL GROUP BOUND TO NITROGEN ATOM IN THE RING
  申请人：MOCHIDA PHARMACEUTICAL CO., LTD.

  公开号：EP1864984A1

  公开（公告）日：2007-12-12

  It is intended to provide an anticoagulant that has an extremely excellent FXa inhibitory action and an extremely weak hERG channel inhibitory action and can be orally administered, which is a compound represented by the following formula (I) or a pharmaceutically acceptable salt thereof.

  本研究旨在提供一种具有极佳的 FXa 抑制作用和极弱的 hERG 通道抑制作用且可口服的抗凝血剂，它是由下式（I）代表的化合物或其药学上可接受的盐。