3-Fluoro-2,4-dimethylpyridine | 1227575-02-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 3-Fluoro-2,4-dimethylpyridine
• CAS: 1227575-02-1
• 化学式: C₇H₈FN
• 分子量: 125.14
• InChiKey: ANSKFBDJVMXKBH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  9
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  12.9
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• [EN] COMPOUNDS AND USES THEREOF<br/>[FR] COMPOSÉS ET LEURS UTILISATIONS
  申请人：FOGHORN THERAPEUTICS INC

  公开号：WO2021155320A1

  公开（公告）日：2021-08-05

  The present disclosure features compounds useful for the treatment of BAF complex-related disorders.

  本公开涉及用于治疗BAF复合物相关疾病的化合物。
• DERIVATIVES AND METHODS OF TREATING HEPATITIS B INFECTIONS
  申请人：Novira Therapeutics, Inc.

  公开号：US20160185777A1

  公开（公告）日：2016-06-30

  Provided herein are compounds useful for the treatment of HBV infection in a subject in need thereof, pharmaceutical compositions thereof, and methods of inhibiting, suppressing, or preventing HBV infection in the subject.

  本文提供了一些用于治疗HBV感染的化合物，以及它们的药物组合物和在患有该病的受试者中抑制、抑制或预防HBV感染的方法。
• ARYL INDOLE DERIVATIVES
  申请人：Kishino Hiroyuki

  公开号：US20120022078A1

  公开（公告）日：2012-01-26

  A novel aryl indole derivative is provided that is effective as a preventive or remedy for various diseases. A compound represented by a formula (I) or a pharmaceutically acceptable salt thereof: (I) wherein R 1 is a hydrogen atom, halogen, C 1-6 alkyl, haloC 1-6 alkyl, C 1-6 alkyloxy, or haloC 1-6 alkyloxy; R 2 represents C 1-6 alkyl or haloC 1-6 alkyl; R 3 represents a hydrogen atom, C 1-6 alkyl, or haloC 1-6 alkyl; and Ar represents an aryl or heteroaryl, wherein the aryl or the heteroaryl may be substituted with 1 to 3 substituents such as halogen, C 1-6 alkyl, haloC 1-6 alkyl, and C 1-6 alkyloxy.

  提供了一种新颖的芳基吲哚衍生物，可作为预防或治疗各种疾病的有效药物。代表为化学式（I）或其药用可接受盐的化合物：（I）其中R1为氢原子、卤素、C1-6烷基、卤代C1-6烷基、C1-6烷氧基或卤代C1-6烷氧基；R2代表C1-6烷基或卤代C1-6烷基；R3代表氢原子、C1-6烷基或卤代C1-6烷基；Ar代表芳基或杂环芳基，其中芳基或杂环芳基可被1至3个取代基（如卤素、C1-6烷基、卤代C1-6烷基和C1-6烷氧基）取代。
• [EN] ARYL INDOLE DERIVATIVES<br/>[FR] DÉRIVÉS D'ARYL-INDOLE
  申请人：BANYU PHARMA CO LTD

  公开号：WO2010117085A1

  公开（公告）日：2010-10-14

  A novel aryl indole derivative is provided that is effective as a preventive or remedy for various diseases. A compound represented by a formula (I) or a pharmaceutically acceptable salt thereof: (I) wherein R1 is a hydrogen atom, halogen, C1-6alkyl, haloC1-6alkyl, C1-6alkyloxy, or haloC1-6alkyloxy; R2 represents C1-6alkyl or haloC1-6alkyl; R3 represents a hydrogen atom, C1-6alkyl, or haloC1-6alkyl; and Ar represents an aryl or heteroaryl, wherein the aryl or the heteroaryl may be substituted with 1 to 3 substituents such as halogen, C1-6alkyl, haloC1-6alkyl, and C1-6alkyloxy.

  提供了一种新的芳基吲哚衍生物，可作为各种疾病的预防或治疗药物。该化合物由以下公式（I）或其药学上可接受的盐所表示：（I）其中R1是氢原子，卤素，C1-6烷基，卤代C1-6烷基，C1-6烷氧基或卤代C1-6烷氧基；R2代表C1-6烷基或卤代C1-6烷基；R3代表氢原子，C1-6烷基或卤代C1-6烷基；Ar代表芳基或杂环芳基，其中芳基或杂环芳基可被1至3个取代基取代，如卤素，C1-6烷基，卤代C1-6烷基和C1-6烷氧基。
• [EN] PIPERIDIN-4-YL AZETIDINE DERIVATIVES AS JAK1 INHIBITORS<br/>[FR] DÉRIVÉS DE PIPÉRIDIN-4-YL AZÉTIDINE EN TANT QU'INHIBITEURS DE JAK1
  申请人：INCYTE CORP

  公开号：WO2011112662A1

  公开（公告）日：2011-09-15

  The present invention provides piperidin-4-yl azetidine derivatives, as well as their compositions and methods of use, that modulate the activity of Janus kinase 1 (JAK1) and are useful in the treatment of diseases related to the activity of JAK1 including, for example, inflammatory disorders, autoimmune disorders, cancer, and other diseases.

  本发明提供了哌啶-4-基氮杂环衍生物及其组合物和使用方法，其调节Janus激酶1（JAK1）的活性，并且对于治疗与JAK1活性相关的疾病具有用处，例如炎症性疾病，自身免疫性疾病，癌症和其他疾病。