| 1327201-60-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• CAS: 1327201-60-4
• 化学式: C₁₉H₂₃NO
• 分子量: 281.398
• InChiKey: HDXSGNDOBBMTID-IBGZPJMESA-N

反应信息

• 作为反应物：
  描述：

  在 β-环糊精 、 2-碘酰基苯甲酸 作用下， 以 水 为溶剂， 反应 6.0h， 以78%的产率得到1-benzyl-2-(benzyloxymethyl)-1H-pyrrole
  参考文献：
  名称：

  o-Iodoxybenzoic acid (IBX): a versatile reagent for the synthesis of N-substituted pyrroles mediated by β-cyclodextrin in water

  摘要：

  o-Iodoxybenzoic acid (IBX), a very mild and efficient hypervalent iodine(V) reagent, aromatizes diversely substituted 1-benzylpyrrolidines and N-substituted L-proline analogues to the corresponding substituted pyrroles in good to excellent yields under mild conditions mediated by beta-cyclodextrin in water at room temperature. To the best of our knowledge, this is the first report on IBX, promoting complete aromatization leading to N-benzylpyrroles from the corresponding saturated five membered heterocyclic derivatives in water medium. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2011.06.077