| 1182734-36-6

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 大环内酯类和类似物
• CAS: 1182734-36-6
• 化学式: C₃₆H₄₄F₃NO₇
• 分子量: 659.743
• InChiKey: MVPBLKBJIMPDJR-PKQSDMQVSA-N

反应信息

• 作为产物：
  描述：

  torrubiellutin A 、 (R)-methoxytrifluoromethylphenylacetyl chloride 在 吡啶 作用下， 以 二氯甲烷 为溶剂， 反应 96.0h， 以0.6 mg的产率得到
  参考文献：
  名称：

  Torrubiellutins A–C, from insect pathogenic fungus Torrubiella luteorostrata BCC 12904

  摘要：

  Investigation of the insect pathogenic fungus Torrubiella luteorostrota led to the isolation of three new macrocyclic torrubiellutins A-C (1-3) and the known pyrone diterpene 4. Structures were elucidated by spectroscopic data including 1D, 2D NMR, and MS spectral data. The absolute stereochemistry was determined by chemical means using Mosher reactions and Marfey's reagent, together with NCESY spectral data. Torrubiellutin C showed biological activities against KB, MCF-7, NCI-H187, and Vero cell lines with IC(50) varying from 0.78 to 4.36 mu g/mL, while compound 4 exhibited antimalaria and anti-inflammatory activity with IC(50) values of 3.49 and 1.21 mu g/mL, respectively. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2009.05.070