Ethyl 2-(3-chloro-2,4,5-trifluoro-6-methylbenzoyl)-3-ethoxy acrylate | 132630-90-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Ethyl 2-(3-chloro-2,4,5-trifluoro-6-methylbenzoyl)-3-ethoxy acrylate
• CAS: 132630-90-1
• 化学式: C₁₅H₁₄ClF₃O₄
• 分子量: 350.722
• InChiKey: LOQNPQSKKUGSSP-SOFGYWHQSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.73
• 重原子数：
  23.0
• 可旋转键数：
  6.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  52.6
• 氢给体数：
  0.0
• 氢受体数：
  4.0

文献信息

• Antibacterial agents
  申请人：WARNER-LAMBERT COMPANY

  公开号：EP0326891A2

  公开（公告）日：1989-08-09

  Novel naphthyridine-, and quinolinecarboxylic acids as antibacterial agents are described as well as methods for their manufacture, formulation, and use in treating bacterial infections including the description of certain novel intermediates used in the manufacture of the antibacterial agents.

  介绍了作为抗菌剂的新型萘啶酸和喹啉羧酸及其制造、配制和用于治疗细菌感染的方法，包括用于制造抗菌剂的某些新型中间体。
• Benzoheterocyclic compounds
  申请人：OTSUKA PHARMACEUTICAL CO., LTD.

  公开号：EP0565132A2

  公开（公告）日：1993-10-13

  Novel 4-oxoquinoline-3-carboxylic acid compounds of the formula: wherein R¹ is cyclopropyl which may have 1 to 3 substituents of alkyl and halogen; phenyl which may be substituted by 1 to 3 substituents of alkoxy, halogen and OH; alkyl which may be substituted by halogen, alkanoyloxy or OH; alkenyl; or thienyl, R² is 5- to 9-membered saturated or unsaturated heterocyclic ring which may be sustituted, R³ is H, alkyl or halogen, R⁴ is alkyl or halogen, R is H or alkyl, R¹ and R³ may be taken together to form wherein R³¹ is H or alkyl, and X is halogen, provided that R³ and R⁴ are not simultaneously halogen, and that when R³ is H, R⁴ is alkyl, and salts thereof, said compounds having excellent antimicrobial activity and hence being useful as an antimicrobial agent, and a pharmaceutical composition containing said compound as an active ingredient.

  式中的新型 4-氧代喹啉-3-羧酸化合物： 其中 R¹ 是环丙基，可被 1 至 3 个烷基和卤素取代；苯基，可被 1 至 3 个烷氧基、卤素和 OH 取代；烷基，可被卤素、烷酰氧基或 OH 取代；烯基；或噻吩基，R² 是 5 至 9 元饱和或不饱和杂环，可被取代，R³ 是 H、烷基或卤素，R⁴ 是烷基或卤素，R 是 H 或烷基，R¹ 和 R³ 可结合在一起形成 其中 R³¹ 是 H 或烷基，X 是卤素，条件是 R³ 和 R⁴ 不同时是卤素，当 R³ 是 H 时，R⁴ 是烷基，以及它们的盐，所述化合物具有优异的抗菌活性，因此可用作抗菌剂，以及含有所述化合物作为活性成分的药物组合物。
• 7-Piperazinyl- or 7-Morpholino-4-oxo-quinoline-3-carboxylic acid derivatives, their preparation and their use as antimicrobial agents
  申请人：OTSUKA PHARMACEUTICAL CO., LTD.

  公开号：EP0287951B1

  公开（公告）日：1996-07-03
• ANTIBACTERIAL AGENTS
  申请人：WARNER-LAMBERT COMPANY

  公开号：EP0398967A1

  公开（公告）日：1990-11-28
• US4920120A
  申请人：——

  公开号：US4920120A

  公开（公告）日：1990-04-24