ethyl 1-(2-((3S,4R)-4-(4-amino-5-chloro-2-methoxybenzamido)-3-methoxypiperidin-1-yl)acetyl)piperidine-4-carboxylate | 860170-43-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: ethyl 1-(2-((3S,4R)-4-(4-amino-5-chloro-2-methoxybenzamido)-3-methoxypiperidin-1-yl)acetyl)piperidine-4-carboxylate
• 英文别名: ethyl 1-[2-[(3S,4R)-4-[(4-amino-5-chloro-2-methoxybenzoyl)amino]-3-methoxypiperidin-1-yl]acetyl]piperidine-4-carboxylate
• CAS: 860170-43-0
• 化学式: C₂₄H₃₅ClN₄O₆
• 分子量: 511.018
• InChiKey: JANFWDDNXSKYHH-CTNGQTDRSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  35
• 可旋转键数：
  9
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  123
• 氢给体数：
  2
• 氢受体数：
  8

文献信息

• Stereoisomeric compounds and methods for the treatment of gastrointestinal and central nervous system disorders
  申请人：Irwin Ian

  公开号：US20050197363A1

  公开（公告）日：2005-09-08

  The subject invention provides stereoisomeric compounds of formula (X): wherein the variables are as defined herein, and compositions for the safe and effective treatment of various gastrointestinal disorders including, but not limited to, gastroparesis, gastroesophageal reflux and related conditions. The compounds of the subject invention are also useful in treating a variety of conditions involving the central nervous system.

  本发明提供了式（X）的立体异构化合物，其中变量如此处所定义，并提供用于安全有效治疗各种胃肠道疾病的组合物，包括但不限于胃轻瘫，胃食管反流和相关疾病。本发明的化合物还可用于治疗涉及中枢神经系统的各种疾病。
• Stereoisomeric Compounds And Methods For The Treatment Of Gastrointestinal And Central Nervous System Disorders
  申请人：Irwin Ian

  公开号：US20080085921A1

  公开（公告）日：2008-04-10

  The subject invention provides stereoisomeric compounds of formula (X): wherein the variables are as defined herein, and compositions for the safe and effective treatment of various gastrointestinal disorders including, but not limited to, gastroparesis, gastroesophageal reflux and related conditions. The compounds of the subject invention are also useful in treating a variety of conditions involving the central nervous system.

  本发明提供了式（X）的立体异构化合物： 其中变量如本文所定义，并提供了用于治疗各种胃肠道疾病的安全有效的组合物，包括但不限于胃轻瘫，胃食管反流和相关疾病。本发明的化合物还可用于治疗涉及中枢神经系统的各种疾病。
• Stereoisomeric Compounds and Methods for the Treatment of Gastrointestinal and Central Nervous System Disorders
  申请人：Irwin Ian

  公开号：US20130040987A1

  公开（公告）日：2013-02-14

  The subject invention provides stereoisomeric compounds of formula (X): wherein the variables are as defined herein, and compositions for the safe and effective treatment of various gastrointestinal disorders including, but not limited to, gastroparesis, gastroesophageal reflux and related conditions. The compounds of the subject invention are also useful in treating a variety of conditions involving the central nervous system.

  该发明涉及式子（X）的立体异构化合物，其中变量如此定义，并提供用于治疗各种胃肠道疾病的安全有效的组合物，包括但不限于胃轻瘫、胃食管反流和相关疾病。该发明的化合物还可用于治疗涉及中枢神经系统的各种疾病。
• STEREOISOMERIC COMPOUNDS AND METHODS FOR THE TREATMENT OF GASTROINTESTINAL AND CENTRAL NERVOUS SYSTEM DISORDERS
  申请人：ARYx Therapeutics

  公开号：EP1704146B1

  公开（公告）日：2010-04-14
• SYNTHETIC METHODS AND INTERMEDIATES FOR STEREOISOMERIC COMPOUNDS USEFUL FOR THE TREATMENT OF GASTROINTESTINAL AND CENTRAL NERVOUS SYSTEM DISORDERS
  申请人：Aryx Therapeutics, Inc.

  公开号：EP1919909A2

  公开（公告）日：2008-05-14