(E)-5-(2-(pyridin-4-yl)vinyl)isophthalic acid | 1098619-72-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (E)-5-(2-(pyridin-4-yl)vinyl)isophthalic acid
• 英文别名: 5-(2-pyridin-4-yl-vinyl)-isophthalic acid；5-[(E)-2-pyridin-4-ylethenyl]benzene-1,3-dicarboxylic acid
• CAS: 1098619-72-7
• 化学式: C₁₅H₁₁NO₄
• 分子量: 269.257
• InChiKey: GYHHFWUPKWAKEB-OWOJBTEDSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  20
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  87.5
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  (E)-dimethyl 5-(2-(pyridin-4-yl)vinyl)isophthalate 在 potassium hydroxide 作用下， 以 水 为溶剂， 反应 12.0h， 以89%的产率得到(E)-5-(2-(pyridin-4-yl)vinyl)isophthalic acid
  参考文献：
  名称：

  从2D到3D：单晶到单晶的光化学构架转换和苯甲醇氧化催化活性

  摘要：

  格子色拉：通过单晶到单晶的光化学[2 + 2]环加成反应，将中性的2D晶格转换为3D多孔网络（见图）。这两个系统都表现出有趣的催化活性，并伴随着由环境光源引起的2D→3D结构转变。

  DOI：

  10.1002/chem.201101321

文献信息

• Trisubstituted carbocyclic cyclophilin binding compounds and their use
  申请人：——

  公开号：US20020165275A1

  公开（公告）日：2002-11-07

  The present invention relates to novel, non-peptidic small organic compounds having an affinity for cyclophilin (CyP)-type immunophilin proteins, and to pharmaceutical compositions comprising one or more of the said compounds. The invention further relates to the uses of these compounds and compositions for binding CyP-type proteins, inhibiting their peptidyl-prolyl isomerase activity, and for research, development, and therapeutic applications in a variety of medical disorders.

  本发明涉及一种新型的非肽类小有机化合物，其具有与环肽亚精蛋白（CyP）型免疫蛋白亲和力，并且涉及包含所述化合物中的一个或多个的药物组合物。该发明还涉及这些化合物和组合物用于结合CyP型蛋白，抑制其肽基脯氨酸异构酶活性，并在各种医学疾病的研究、开发和治疗应用中的用途。
• TRISUBSTITUTED CARBOCYCLIC CYCLOPHILIN BINDING COMPOUNDS AND THEIR USE
  申请人：GUILFORD PHARMACEUTICALS INC.

  公开号：EP1360173A2

  公开（公告）日：2003-11-12
• Micropattern retardation element
  申请人：Matsunaga Daisaku

  公开号：US20070134442A1

  公开（公告）日：2007-06-14

  The present invention relates to a micropattern retardation element requiring no stretch processing and no extremely high positioning accuracy in cutting films, and the like, and having the retardation region controlled in width of a micron unit, and a producing method therefore. Said micropattern retardation element can be obtained by forming a liquid crystalline or non liquid crystalline polymer thin film layer having photoactive groups, on a substrate, and then, after orientation treatment in a micropattern form, forming a birefringence layer so as to contact with said polymer thin film layer, so that birefringence molecules of said birefringence layer are oriented according to orientation of photoactive groups in said thin film. Said retardation element is used in a three-dimensional display, and the like.
• US6656971B2
  申请人：——

  公开号：US6656971B2

  公开（公告）日：2003-12-02
• [EN] TRISUBSTITUTED CARBOCYCLIC CYCLOPHILIN BINDING COMPOUNDS AND THEIR USE<br/>[FR] COMPOSES DE LIAISON DE LA CYCLOPHILINE CARBOXYLIQUE TRISUBSTITUEE ET LEUR UTILISATION
  申请人：GUILFORD PHARM INC

  公开号：WO2002059080A2

  公开（公告）日：2002-08-01

  The present invention relates to novel, non-peptidic small organic compounds having an affinity for cyclophilin (CyP)-type immunophilin proteins, and to pharmaceutical compositions comprising one or more of the said compounds. The invention further relates to the uses of these compounds and compositions for binding CyP-type proteins, inhibiting their peptidyl-prolyl isomerase activity, and for research, development, and therapeutic applications in a variety of medical disorders.