[(3S)-3-amino-3-carboxypropyl][(4-methoxy-3-nitrophenyl)hydroxymethyl]phosphinic acid | 936234-60-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: [(3S)-3-amino-3-carboxypropyl][(4-methoxy-3-nitrophenyl)hydroxymethyl]phosphinic acid
• 英文别名: LSP1-2101；(3S)-3-[(((3-amino-3-carboxy)propyl)(hydroxy)phosphinyl)-hydroxymethyl]-3-nitro-4-methoxybenzene；(2S)-2-amino-4-[hydroxy-[hydroxy-(4-methoxy-3-nitrophenyl)methyl]phosphoryl]butanoic acid
• CAS: 936234-60-5
• 化学式: C₁₂H₁₇N₂O₈P
• 分子量: 348.249
• InChiKey: HSHWJQGGJKYMDI-KBPLZSHQSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -3.6
• 重原子数：
  23
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  176
• 氢给体数：
  4
• 氢受体数：
  9

反应信息

• 作为反应物：
  描述：

  [(3S)-3-amino-3-carboxypropyl][(4-methoxy-3-nitrophenyl)hydroxymethyl]phosphinic acid 在 盐酸 作用下， 以 水 为溶剂， 生成 [(3S,1'R)-3-amino-3-carboxypropyl][(4-methoxy-3-nitrophenyl)hydroxymethyl]phosphinic acid hydrochloride 、 [(3S,1'S)-3-amino-3-carboxypropyl][(4-methoxy-3-nitrophenyl)hydroxymethyl]phosphinic acid hydrochloride
  参考文献：
  名称：

  [EN] DIASTEREOISOMERS OF HYPOPHOSPHOROUS ACID DERIVATIVES
  [FR] DIASTÉRÉOISOMÈRES DE DÉRIVÉS D'ACIDE HYPOPHOSPHOREUX

  摘要：

  该发明涉及具有式（I）的次磷酸衍生物的对映异构体，其中苯基被一个或多个原子或基团取代，占据苯环上的一个或多个位置，并提供了一种分离它们的方法。

  公开号：

  WO2010106526A1
• 作为产物：
  描述：

  [(3S)-3-(N-benzyloxycarbonyl)amino-3-methoxycarbonylpropyl][(4-methoxy-3-nitrophenyl)hydroxymethyl]phosphinic acid 在 盐酸 作用下， 反应 5.0h， 以304 mg的产率得到[(3S)-3-amino-3-carboxypropyl][(4-methoxy-3-nitrophenyl)hydroxymethyl]phosphinic acid
  参考文献：
  名称：

  Increased Potency and Selectivity for Group III Metabotropic Glutamate Receptor Agonists Binding at Dual sites

  摘要：

  A group III metabotropic glutamate (mGlu) receptor agonist (PCEP) was identified by virtual HTS. This orthosteric ligand is composed by an L-AP4-derived fragment that mimics glutamate and a chain that binds into a neighboring pocket, offering possibilities to improve affinity and selectivity. Herein we describe a series of derivatives where the distal chain is replaced by an aromatic or heteroaromatic group. Potent agonists were identified, including some with a mGlu(4) subtype preference, e.g., 17m (LSP1-2111) and 16g (LSP4-2022). Molecular modeling suggests that aromatic functional groups may bind at either one of the two chloride regulatory sites. These agonists may thus be considered as particular bitopic/dualsteric ligands. 17m was shown to reduce GABAergic synaptic transmission at striatopallidal synapses. We now demonstrate its inhibitory effect at glutamatergic parallel fiber-Purkinje cell synapses in the cerebellar cortex. Although these ligands have physicochemical properties that are markedly different from typical CNS drugs, they hold significant therapeutic potential.

  DOI：

  10.1021/acs.jmedchem.7b01438

文献信息

• Hypophosphorous Acid Derivatives and their Therapeutical Applications
  申请人：Acher Francine

  公开号：US20090170813A1

  公开（公告）日：2009-07-02

  Hypophosphorous acid derivatives having Formula (I) wherein .M is a [C(R3,R4)]n1-C(E,COOR1,N(H,Z)) group, or an optionally substituted Ar—CH(COOR1,N(H,Z)) group, or an a, β, or a β, g-cyclic amino acid; .R 1 is H or R, R being an hydroxy or a carboxy protecting group; .Z is H or an amino protecting group R′, benzyl oxycarbonyl, benzyl or benzyl substituted; .E is H or a C1-C3 alkyl, aryl, an hydrophobic group; .R 2 is selected in the group comprising: D-CH(R 6 )—C—(R 7 ,R 8 ), (R 11 ,R 12 )CH—C(R 9 ,R 10 ), D-CH(OH), D-[C(R 13 ,R 14 )] n3 —, C[(R 15 ,R 16 ,R 17 )] n4 , D-CH 2 , (R 18 )CH═C(R 19 ), D-(M 1 ) n6 —CO, Formula (II), PO(OH) 2 —CH 2 or (PO(OH) 2 —CH 2 ), (COOH—CH 2 )—CH 2 , with -D=H, OH, OR, (CH 2 ) n2 OH, (CH 2 ) n1 OR, COOH, COOR, (CH 2 ) n2 COOH, (CH 2 ) n1 COOR, SR, S(OR), SO 2 R, NO 2 , heteroaryl, C 1 -C 3 alkyl, cycloalkyl, heterocycloalkyl, (CH 2 ) n2 -alkyl, (COOH,NH 2 )—(CH 2 ) u1 -cyclopropyl-(CH 2 ) u2 —, CO—NH-alkyl, Ar, (CH 2 ) n2 —Ar, CO—NH—Ar; —R 3 to R 19 being H, OH, OR, (CH 2 ) n2 OH, (CH 2 ) n1 OR, COOH, COOR, (CH 2 ) n2 COOH, (CH 2 ) n1 COOR, C 1 -C 3 alkyl, cycloalkyl, (CH 2 )n1-alkyl, aryl, (CH 2 )n1-aryl, halogen, CF 3 , SO 3 H, (CH 2 ) x PO 3 H 2 , with x=0, 1 or 2, B(OH) 2 , Formula (III), NO 2 , SO 2 NH 2 , SO 2 NHR; SR, S(O)R, SO 2 R, benzyl; -M 1 is an alkylene or arylene group; -n1=1, 2 or 3, n2=1, 2 or 3, n3=0, 1, 2 or 3 and n4=1, 2 or 3, n5=1, 2 or 3, n6=0 or 1, u1 and u2, identical or different=0, 1 or 2, with the proviso that Formula (I) does not represent the racemic (3R,S) and the enantiomeric form (3R) of 3 amino,3-carboxy-propyl-2′-carboxy-ethylphosphinic acid; 3 amino,3-carboxy-propyl-4′carboxy,2′carboxy-butanoylphosphinic acid; 3 amino,3-carboxy-propyl-2′carboxy-butanoylphosphinic acid; 3 amino,3-carboxy-propyl-3′amino, 3′carboxy-propylylphosphinic acid; and 3 amino,3-carboxypropyl-7′amino-2′, 7′-dicarboxyheptylphosphinic acid, said hypophosphorous acid derivatives being diasteroisomers or enantiomers. Application as drugs.

  含有Formula (I)的次磷酸衍生物，其中.M是[C(R3,R4)]n1-C(E,COOR1,N(H,Z))基团，或者是一个可选择取代的Ar—CH(COOR1,N(H,Z))基团，或者是α，β或αβ，γ-环氨基酸；.R1是H或R，R是一个羟基或羧基保护基团；.Z是H或氨基保护基团R′，苄氧羰基，苄基或苄基取代；.E是H或C1-C3烷基，芳基，疏水基团；.R2是从以下群体中选择的：D-CH(R6)—C—(R7,R8)，(R11,R12)CH—C(R9,R10)，D-CH(OH)，D-[C(R13,R14)]n3—，C[(R15,R16,R17)]n4，D-CH2，(R18)CH═C(R19)，D-(M1)n6—CO，Formula (II)，PO(OH)2—CH2或(PO(OH)2—CH2)，(COOH—CH2)—CH2，其中-D=H，OH，OR，(CH2)n2OH，(CH2)n1OR，COOH，COOR，(CH2)n2COOH，(CH2)n1COOR，SR，S(OR)，SO2R，NO2，杂环芳基，C1-C3烷基，环烷基，杂环烷基，(CH2)n2-烷基，(COOH,NH2)—(CH2)u1-环丙基-(CH2)u2—，CO—NH-烷基，Ar，(CH2)n2—Ar，CO—NH—Ar；—R3到R19为H，OH，OR，(CH2)n2OH，(CH2)n1OR，COOH，COOR，(CH2)n2COOH，(CH2)n1COOR，C1-C3烷基，环烷基，(CH2)n1-烷基，芳基，(CH2)n1-芳基，卤素，CF3，SO3H，(CH2)xPO3H2，其中x=0，1或2，B(OH)2，Formula (III)，NO2，SO2NH2，SO2NHR；SR，S(O)R，SO2R，苄基；-M1是一个烷基或芳基基团；-n1=1，2或3，n2=1，2或3，n3=0，1，2或3，n4=1，2或3，n5=1，2或3，n6=0或1，u1和u2，相同或不同=0，1或2，但Formula (I)不代表3-氨基，3-羧基-丙基-2′-羧基-乙磷酸的消旋体(3R,S)和对映体形式(3R)；3-氨基，3-羧基-丙基-4′羧基，2′羧基-丁酰磷酸；3-氨基，3-羧基-丙基-2′羧基-丁酰磷酸；3-氨基，3-羧基-丙基-3′氨基，3′羧基-丙基磷酸；和3-氨基，3-羧基丙基-7′氨基-2′，7′-二羧基庚基磷酸，所述的次磷酸衍生物为二对映异构体或对映体。用作药物的应用。
• DIASTEREOISOMERS OF HYPOPHOSPHOROUS ACID DERIVATIVES
  申请人：Acher Francine

  公开号：US20120016155A1

  公开（公告）日：2012-01-19

  The invention relates to the diastereoisomers of hypophosphorous acid derivatives, having formula (I), wherein the phenyl group is substituted by one or several atoms or groups, occupying one or several positions on the phenyl ring, and a method for the separation thereof.
• [EN] HYPOPHOSPHOROUS ACID DERIVATIVES AND THEIR THERAPEUTICAL APPLICATIONS<br/>[FR] DERIVES ACIDES HYPOPHOSPHORES ET APPLICATIONS THERAPEUTIQUES
  申请人：CENTRE NAT RECH SCIENT

  公开号：WO2007052169A2

  公开（公告）日：2007-05-10

  [EN] Hypophosphorous acid derivatives having Formula (I) wherein . M is a [C(R3,R4)]n1 - C(E,COOR1, N(H, Z)) group, or an optionally substituted Ar-CH(COOR1, N(H, Z)) group, or an a, ß, or a ß, g-cyclic aminoacid; . R₁ is H or R, R being an hydroxy or a carboxy protecting group; . Z is H or an amino protecting group R', benzyl oxycarbonyl, benzyl or benzyl substituted; . E is H or a C1-C3 alkyl, aryl, an hydrophobic group; . R₂ is selected in the group comprising: D-CH(R₆)- C-(R₇, R₈), (R₁₁,R₁₂)CH- C(R₉, R₁₀), D - CH(OH), D- [C(R₁₃, R₁₄)]_n3 -, C[(R₁₅, R₁₆, R₁₇)]_n4, D-CH₂, (R₁₈)CH = C(R₁₉), D-(M₁)_n6-CO, Formula (II), PO(OH)₂-CH₂ or (PO(OH)₂-CH₂), (COOH-CH₂)-CH₂, with - D = H, OH, OR, (CH₂)_n2OH, (CH₂)_n1OR, COOH, COOR, (CH₂)_n2COOH, (CH₂)_n1COOR, SR, S(OR), SO₂R, NO₂, heteroaryl, C₁-C₃ alkyl, cycloalkyl, heterocycloalkyl, (CH₂)_n2-alkyl, (COOH, NH₂)-(CH₂)_u1-cyclopropyl-(CH₂)_u2-, CO-NH-alkyl, Ar, (CH₂)_n2-Ar, CO-NH-Ar; - R₃ to R₁₉ being H, OH, OR, (CH₂)_n2OH, (CH₂)_n1OR, COOH, COOR, (CH₂)_n2COOH, (CH₂)_n1COOR, C₁-C₃ alkyl, cycloalkyl, (CH₂)n1-alkyl, aryl, (CH₂)n1-aryl, halogen, CF₃, SO₃H, (CH₂)_x PO₃H₂, with x = 0, 1 or 2, B(OH)₂ , Formula (III), NO₂ , SO₂NH₂ , SO₂NHR; SR, S(O)R, SO₂R, benzyl; - M₁ is an alkylene or arylene group; - n1= 1, 2 or 3, n2= 1, 2 or 3, n3= 0, 1, 2 or 3 and n4= 1, 2 or 3, n5= 1,2 or 3, n6= 0 or 1, u1 and u2, identical or different = 0,1 or 2, with the proviso that Formula (I) does not represent the racemic (3R, S) and the enantiomeric form (3R) of 3 amino,3-carboxy-propyl-2'-carboxy-ethylphosphinic acid; 3 amino,3-carboxy-propyl- 4'carboxy,2'carboxy-butanoylphosphinic acid; 3 amino,3-carboxy-propyl- 2'carboxy-butanoylphosphinic acid; 3 amino,3-carboxy-propyl- 3'amino, 3'carboxy-propylylphosphinic acid; and 3 amino,3-carboxypropyl -7'amino-2', 7'-dicarboxyheptylphosphinic acid, said hypophosphorous acid derivatives being diasteroisomers or enantiomers. Application as drugs.
  [FR] Cette invention concerne des dérivés acides hypophosphorés représentés par la formule (I). Dans cette formule, M est un groupe [C(R3,R4)]n1 - C(E,COOR1, N(H, Z)), ou un groupe Ar-CH(COOR1, N(H, Z)) éventuellement substitué, ou un acide aminé a, ß, ou g-cyclique; . R₁ est H ou R, R étant un groupe protecteur hydroxy ou carboxy; . Z est H ou un groupe amino protecteur R', benzyl oxycarbonyl, benzyle ou substitué benzyle; E est H ou un C1-C3 alkyle, aryle, un groupe hydrophobe; . R2 est pris dan le groupe comprenant: D-CH(R₆)- C-(R₇, R₈), (R₁₁,R₁₂)CH- C(R₉, R₁₀), D - CH(OH), D- [C(R₁₃, R₁₄)]_n3 -, C[(R₁₅, R₁₆, R₁₇)]_n4, D-CH₂, (R₁₈)CH = C(R₁₉), D-(M₁)_n6-CO, PO(OH)2-CH₂ ou (PO(OH)₂-CH₂), (COOH-CH₂)-CH₂, avec - D = H, OH, OR, (CH₂)_n2OH, (CH₂)_n1OR, COOH, COOR, (CH₂)_n2COOH, (CH₂)_n1COOR, SR, S(OR), SO₂R, NO₂, hétéroaryle, C1-C3 alkyle, cycloalkyle, hétérocycloalkyle, (CH₂)_n2-alkyle, (COOH, NH₂)-(CH₂)_u1-cyclopropyl-(CH₂)_u2-, CO-NH-alkyle, Ar, (CH₂)_n2-Ar, CO-NH-Ar; - R₃ à R₁₉ étant H, OH, OR, (CH₂)_n2OH, (CH₂)_n1OR, COOH, COOR, (CH₂)_n2COOH, (CH₂)_n1COOR, C₁-C₃ alkyle, cycloalkyle, (CH₂)n1-alkyle, aryle, (CH₂)n1-aryle, halogène, CF₃, SO₃H, (CH₂)_x PO₃H₂, avec x = 0, 1 ou 2, B(OH)₂,, NO₂, SO₂NH₂, SO₂NHR; SR, S(O)R, SO₂R, benzyle; - M₁ est un groupe alkylène ou arylène; - n1= 1, 2 ou 3, n2= 1, 2 ou 3, n3= 0, 1, 2 ou 3 et n4= 1, 2 ou 3, n5= 1,2 ou 3, n6= 0 or 1, u1 and u2, identiques ou différents = 0,1 ou 2, à condition quela formule (I) ne représenter pas la forme racémique (3R, S) ni la forme énantiomère (3R) de 3 amino,3-carboxy-propyl-2'-carboxy-éthylphosphinique acide; 3 amino,3-carboxy-propyl- 4'carboxy,2'carboxy-butanoylphosphinique acide; 3 amino,3-carboxy-propyl- 2'carboxy-butanoylphosphinique acide; 3 amino,3-carboxy-propyl- 3'amino, 3'carboxy-propylylphosphinique acide; and 3 amino,3-carboxypropyl -7'amino-2', 7'-dicarboxyheptylphosphinique acide, lesdits dérivées acides hypophosphorés étant des diastero-isoméres ou des énantiomères. Cette invention concerne également l'application de ces dérivés en tant que médicaments.
• Increased Potency and Selectivity for Group III Metabotropic Glutamate Receptor Agonists Binding at Dual sites
  作者：Chelliah Selvam、Isabelle A. Lemasson、Isabelle Brabet、Nadia Oueslati、Berin Karaman、Alexandre Cabaye、Amélie S. Tora、Bruno Commare、Tiphanie Courtiol、Sara Cesarini、Isabelle McCort-Tranchepain、Delphine Rigault、Laetitia Mony、Thomas Bessiron、Heather McLean、Frédéric R. Leroux、Françoise Colobert、Hervé Daniel、Anne Goupil-Lamy、Hugues-Olivier Bertrand、Cyril Goudet、Jean-Philippe Pin、Francine C. Acher

  DOI：10.1021/acs.jmedchem.7b01438

  日期：2018.3.8

  A group III metabotropic glutamate (mGlu) receptor agonist (PCEP) was identified by virtual HTS. This orthosteric ligand is composed by an L-AP4-derived fragment that mimics glutamate and a chain that binds into a neighboring pocket, offering possibilities to improve affinity and selectivity. Herein we describe a series of derivatives where the distal chain is replaced by an aromatic or heteroaromatic group. Potent agonists were identified, including some with a mGlu(4) subtype preference, e.g., 17m (LSP1-2111) and 16g (LSP4-2022). Molecular modeling suggests that aromatic functional groups may bind at either one of the two chloride regulatory sites. These agonists may thus be considered as particular bitopic/dualsteric ligands. 17m was shown to reduce GABAergic synaptic transmission at striatopallidal synapses. We now demonstrate its inhibitory effect at glutamatergic parallel fiber-Purkinje cell synapses in the cerebellar cortex. Although these ligands have physicochemical properties that are markedly different from typical CNS drugs, they hold significant therapeutic potential.
• [EN] DIASTEREOISOMERS OF HYPOPHOSPHOROUS ACID DERIVATIVES<br/>[FR] DIASTÉRÉOISOMÈRES DE DÉRIVÉS D'ACIDE HYPOPHOSPHOREUX
  申请人：CENTRE NAT RECH SCIENT

  公开号：WO2010106526A1

  公开（公告）日：2010-09-23

  The invention relates to the diastereoisomers of hypophosphorous acid derivatives, having formula (I), wherein the phenyl group is substituted by one or several atoms or groups, occupying one or several positions on the phenyl ring, and a method for the separation thereof.

  该发明涉及具有式（I）的次磷酸衍生物的对映异构体，其中苯基被一个或多个原子或基团取代，占据苯环上的一个或多个位置，并提供了一种分离它们的方法。