4-硝基苯基[1-14C]棕榈酸酯 | 1038926-74-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 4-硝基苯基[1-14C]棕榈酸酯
• 英文名称: 4-nitrophenyl [1-14C]palmitate
• CAS: 1038926-74-7
• 化学式: C₂₂H₃₅NO₄
• 分子量: 379.513
• InChiKey: LVZSQWIWCANHPF-FSEIIBCTSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.98
• 重原子数：
  27.0
• 可旋转键数：
  16.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.68
• 拓扑面积：
  69.44
• 氢给体数：
  0.0
• 氢受体数：
  4.0

反应信息

• 作为产物：
  描述：

  对硝基苯酚 、 软脂-(羧基-14C)酸 在 4-二甲氨基吡啶 作用下， 以 二氯甲烷 为溶剂， 生成 4-硝基苯基[1-14C]棕榈酸酯
  参考文献：
  名称：

  Fatty acid-binding site environments of serum vitamin D-binding protein and albumin are different

  摘要：

  Vitamin D-binding protein (DBP) and albumin (ALB) are abundant serum proteins and both possess high-affinity binding for saturated and unsaturated fatty acids. However, certain differences exist. We surmised that in cases where serum albumin level is low, DBP presumably can act as a transporter of fatty acids. To explore this possibility we synthesized several alkylating derivatives of 14 C-palmitic acid to probe the fatty acid-binding pockets of DBP and ALB. We observed that N-ethyl-5-phenylisooxzLzolium-3'-sulfonate-ester (WRX-ester) of C-14-palmitic acid specifically labeled DBP; but p-nitrophenyl- and N-hydroxysuccinimidyl-esters failed to do so. However, p-nitrophenyl ester of C-14-palmitic acid specifically labeled bovine ALB, indicating that the micro-environment of the fatty acid-binding domains of DBP and ALB may be different; and DBP may not replace ALB as a transporter of fatty acids. (C) 2008 Elsevier Inc. All rights reserved.

  DOI：

  10.1016/j.bioorg.2008.02.002