1-[5-(3'-Chloro-2-fluoro-6-methoxy-biphenyl-3-ylmethyl)-pyrimidin-2-yl]-pyrrolidine-3-carboxylic acid | 1155877-40-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-[5-(3'-Chloro-2-fluoro-6-methoxy-biphenyl-3-ylmethyl)-pyrimidin-2-yl]-pyrrolidine-3-carboxylic acid
• 英文别名: 1-[5-[[3-(3-Chlorophenyl)-2-fluoro-4-methoxyphenyl]methyl]pyrimidin-2-yl]pyrrolidine-3-carboxylic acid
• CAS: 1155877-40-9
• 化学式: C₂₃H₂₁ClFN₃O₃
• 分子量: 441.889
• InChiKey: DKYFNANOCZQOEL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  31
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.26
• 拓扑面积：
  75.6
• 氢给体数：
  1
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  1-[5-(3'-Chloro-2-fluoro-6-methoxy-biphenyl-3-ylmethyl)-pyrimidin-2-yl]-pyrrolidine-3-carboxylic acid methyl ester 在 水 、 三氟乙酸 作用下， 以 二氯甲烷 为溶剂， 以93%的产率得到1-[5-(3'-Chloro-2-fluoro-6-methoxy-biphenyl-3-ylmethyl)-pyrimidin-2-yl]-pyrrolidine-3-carboxylic acid
  参考文献：
  名称：

  BIARYL PDE4 INHIBITORS FOR TREATING PULMONARY AND CARDIOVASCULAR DISORDERS

  摘要：

  本发明涉及一类含有至少一个进一步环的联苯化合物的属。这些化合物是PDE4抑制剂，用于治疗和预防中风、心肌梗死和心血管炎症性疾病和紊乱。这些化合物具有一般式Ia、Ib、Ic或Id： 一个特定的实施例是

  公开号：

  US20090136473A1

文献信息

• BIARYL PDE4 INHIBITORS FOR TREATING PULMONARY AND CARDIOVASCULAR DISORDERS
  申请人：SINGH Jasbir

  公开号：US20120213758A1

  公开（公告）日：2012-08-23

  The present invention relates to a genus of biaryl compounds containing at least one further ring. The compounds are PDE4 inhibitors useful for the treatment and prevention of stroke, myocardial infarct and cardiovascular inflammatory diseases and disorders. The compounds have general formula Ia, Ib, Ic or Id: A particular embodiment is

  本发明涉及一类含有至少一个进一步环的双芳基化合物。这些化合物是PDE4抑制剂，可用于治疗和预防中风、心肌梗死和心血管炎症性疾病和紊乱。这些化合物的一般式为Ia、Ib、Ic或Id：其中一种特定的实施例为：
• Biaryl PDE4 inhibitors for treating pulmonary and cardiovascular disorders
  申请人：Decode Genetics EHF

  公开号：EP2628727A2

  公开（公告）日：2013-08-21

  The present invention relates to a genus of biaryl compounds containing at least one further ring. The compounds are PDE4 inhibitors useful for the treatment and prevention of stroke, myocardial infarct and cardiovascular inflammatory diseases and disorders. The compounds have general formula Ia, Ib, Ic or Id: or salt thereof, in particular a pharmaceutically acceptable salt thereof.

  本发明涉及一种含有至少一个附加环的双芳基化合物。这些化合物是 PDE4 抑制剂，可用于治疗和预防中风、心肌梗塞和心血管炎症性疾病和紊乱。这些化合物具有通式 Ia、Ib、Ic 或 Id： 或其盐，特别是其药学上可接受的盐。
• [EN] BIARYL PDE4 INHIBITORS FOR TREATING PULMONARY AND CARDIOVASCULAR DISORDERS<br/>[FR] INHIBITEURS DE BIARYLE PDE4 POUR LE TRAITEMENT DE TROUBLES PULMONAIRES ET CARDIOVASCULAIRES
  申请人：DECODE GENETICS EHF

  公开号：WO2009067621A1

  公开（公告）日：2009-05-28

  The present invention relates to a genus of biaryl compounds containing at least one further ring. The compounds are PDE4 inhibitors useful for the treatment and prevention of stroke, myocardial infarct and cardiovascular inflammatory diseases and disorders. The compounds have general formula (Ia), (Ib), (Ic) or (Id). A particular embodiment is formula (I).
• BIARYL PDE4 INHIBITORS FOR TREATING PULMONARY AND CARDIOVASCULAR DISORDERS
  申请人：Singh Jasbir

  公开号：US20090136473A1

  公开（公告）日：2009-05-28

  The present invention relates to a genus of biaryl compounds containing at least one further ring. The compounds are PDE4 inhibitors useful for the treatment and prevention of stroke, myocardial infarct and cardiovascular inflammatory diseases and disorders. The compounds have general formula Ia, Ib, Ic or Id: A particular embodiment is

  本发明涉及一类含有至少一个进一步环的联苯化合物的属。这些化合物是PDE4抑制剂，用于治疗和预防中风、心肌梗死和心血管炎症性疾病和紊乱。这些化合物具有一般式Ia、Ib、Ic或Id： 一个特定的实施例是