| 1189587-87-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• CAS: 1189587-87-8
• 化学式: C₁₆H₁₆Cl₂N₄S
• 分子量: 367.302
• InChiKey: GIFDEFOFRLEMRU-UHFFFAOYSA-N

反应信息

• 作为反应物：
  描述：

  N-甲基马来酰亚胺 、 以 苯 为溶剂， 反应 0.5h， 以92%的产率得到(2,4-dichlorophenylazo)-(2-methyl-1,3-dioxooctahydropyrrolo[3,4-a]pyrrolizin-4-ylidene)acetonitrile
  参考文献：
  名称：

  3-Alkylsulfanyl-2-arylazo-3-(pyrrolidin-1-yl)-acrylonitriles as masked 1,3-dipoles

  摘要：

  Reaction of 3-alkylsulfanyl-2-arylazo-3-(pyrrolidin-1-yl)acrylonitriles with maleimides, dimethyl maleate and dimethylacetylene dicarboxylate were carried out to give octahydro-pyrrolo[3,4-alpha]pyrrolizin-4-ylidenes, hexahydro-pyrrolizines and 6,7-dihydro-5H-pyrrolizines. The formation of the synthesized compounds is explained by a 1,3-dipolar cycloaddition of an in situ generated azomethine ylide. The mechanisms of the formation of these active intermediates were discussed with the aid of density functional theory methods with the B3LYP functional 6-31G(+) calculations using the STAN method and chemical experiments. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2009.06.114