N-(4-chlorophenyl)-2-[(2-cyanopyridin-3-yl)oxy]acetamide | 727737-02-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-(4-chlorophenyl)-2-[(2-cyanopyridin-3-yl)oxy]acetamide
• 英文别名: N-(4-Chlorophenyl)-2-[(2-cyano-3-pyridinyl)oxy]acetamide；N-(4-chlorophenyl)-2-(2-cyanopyridin-3-yl)oxyacetamide
• CAS: 727737-02-2
• 化学式: C₁₄H₁₀ClN₃O₂
• 分子量: 287.705
• InChiKey: PEHJXZNLNFOFOO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  20
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  75
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• Fused furan compound
  申请人：Kawaguchi Takayuki

  公开号：US20060094724A1

  公开（公告）日：2006-05-04

  The present invention provides a condensed furan compound of the formula (I): wherein Ring X is benzene, pyridine, or the like; Y is an optionally substituted amino, an optionally substituted cycloalkyl, an optionally substituted aryl, an optionally substituted saturated heterocyclic group, an optionally substituted unsaturated heterocyclic group; A is a single bond, lower alkylene, lower alkenylidene, lower alkenylene or an oxygen atom; R 3 is hydrogen or the like; and, R 4 is hydrogen, or the like, or pharmaceutically acceptable salts thereof, which is useful as a medicament, particularly, as an activated blood coagulation factor X inhibitor.

  本发明提供了式(I)的紧凑呋喃化合物：其中环X是苯、吡啶或类似物；Y是可选取代的氨基、可选取代的环烷基、可选取代的芳基、可选取代的饱和杂环基、可选取代的不饱和杂环基；A是单键、低级烷基、低级烯基亚烷基、低级烯基亚烯基或氧原子；R3是氢或类似物；R4是氢或类似物，或其药学上可接受的盐，其用作药物，特别是作为激活的血凝血酶X抑制剂。
• Condensed furan compounds
  申请人：Kawaguchi Takayuki

  公开号：US20090156803A1

  公开（公告）日：2009-06-18

  The present invention provides a condensed furan compound of the formula (I): wherein Ring X is benzene, pyridine, or the like; Y is an optionally substituted amino, an optionally substituted cycloalkyl, an optionally substituted aryl, an optionally substituted saturated heterocyclic group, an optionally substituted unsaturated heterocyclic group; A is a single bond, lower alkylene, lower alkenylidene, lower alkenylene or an oxygen atom; R 3 is hydrogen or the like; and, R 4 is hydrogen, or the like, or pharmaceutically acceptable salts thereof, which is useful as a medicament, particularly, as an activated blood coagulation factor X inhibitor.

  本发明提供了一种公式（I）的紧凑呋喃化合物：其中环X为苯、吡啶或类似物；Y为可选取代的氨基、可选取代的环烷基、可选取代的芳基、可选取代的饱和杂环基、可选取代的不饱和杂环基；A为单键、低碳烷基、低碳烯基亚甲基、低碳烯基或氧原子；R3为氢或类似物；R4为氢、类似物或药学上可接受的盐，其作为药物特别是作为激活的血凝血酶X抑制剂非常有用。
• FUSED FURAN COMPOUND
  申请人：TANABE SEIYAKU CO., LTD.

  公开号：EP1582521A1

  公开（公告）日：2005-10-05

  The present invention provides a condensed furan compound of the formula (I): wherein Ring X is benzene, pyridine, or the like; Y is an optionally substituted amino, an optionally substituted cycloalkyl, an optionally substituted aryl, an optionally substituted saturated heterocyclic group, an optionally substituted unsaturated heterocyclic group; A is a single bond, lower alkylene, lower alkenylidene, lower alkenylene or an oxygen atom; R3 is hydrogen or the like; and , R4 is hydrogen, or the like, or pharmaceutically acceptable salts thereof, which is useful as a medicament, particularly, as an activated blood coagulation factor X inhibitor.

  本发明提供了一种式（I）的缩合呋喃化合物： 其中，环 X 是苯、吡啶或类似物；Y 是任选取代的氨基、任选取代的环烷基、任选取代的芳基、任选取代的饱和杂环基团、任选取代的不饱和杂环基团；A 是单键、低级亚烷基、低级亚烯基、低级亚烯基或氧原子；R3 是氢或类似物；以及 ，R4 是氢或类似物，或其药学上可接受的盐，可用作药物，特别是用作活化的凝血因子 X 抑制剂。
• US7514449B2
  申请人：——

  公开号：US7514449B2

  公开（公告）日：2009-04-07
• US7737161B2
  申请人：——

  公开号：US7737161B2

  公开（公告）日：2010-06-15