(3S,4R,5Z,8S,9S,11E)-3,4,9,10-Tetrahydro-8,9,16-trihydroxy-14-[(2-methoxyethyl)amino]-3,4-dimethyl-1H-2-benzoxacyclotetradecin-1,7(8H)-dione | 1108193-01-6

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 大环内酯类和类似物
• 英文名称: (3S,4R,5Z,8S,9S,11E)-3,4,9,10-Tetrahydro-8,9,16-trihydroxy-14-[(2-methoxyethyl)amino]-3,4-dimethyl-1H-2-benzoxacyclotetradecin-1,7(8H)-dione
• 英文别名: (4S,5R,6Z,9S,10S,12E)-9,10,18-trihydroxy-16-(2-methoxyethylamino)-4,5-dimethyl-3-oxabicyclo[12.4.0]octadeca-1(14),6,12,15,17-pentaene-2,8-dione
• CAS: 1108193-01-6
• 化学式: C₂₂H₂₉NO₇
• 分子量: 419.5
• InChiKey: RMHAESHZTBMTMP-URYZQYJQSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  30
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  125
• 氢给体数：
  4
• 氢受体数：
  8

文献信息

• Multikinase inhibitors for use in the treatment of cancer
  申请人：Eisai R&D Management Co., LTD.

  公开号：US11160783B2

  公开（公告）日：2021-11-02

  The present invention provides compounds, pharmaceutical compositions and methods for the treatment of specific cancers. Such compositions may generally comprise a compound of formula (I): wherein R1-R3 are as defined herein, or pharmaceutically acceptable salts or esters thereof; and a pharmaceutically acceptable carrier.

  本发明提供了用于治疗特定癌症的化合物、药物组合物和方法。此类组合物一般包含式（I）化合物： 其中 R1-R3 如本文所定义，或其药学上可接受的盐或酯；以及药学上可接受的载体。
• MULTIKINASE INHIBITORS FOR USE IN THE TREATMENT OF CANCER
  申请人：Eisai R&D Management Co., Ltd.

  公开号：EP2182941B1

  公开（公告）日：2018-02-28
• Multikinase Inhibitors for Use in the Treatment of Cancer
  申请人：Agoulnik Sergei

  公开号：US20090082313A1

  公开（公告）日：2009-03-26

  The present invention provides compounds, pharmaceutical compositions and methods for the treatment of specific cancers. Such compositions may generally comprise a compound of formula (I): wherein R 1 -R 3 are as defined herein, or pharmaceutically acceptable salts or esters thereof; and a pharmaceutically acceptable carrier.
• US8937056B2
  申请人：——

  公开号：US8937056B2

  公开（公告）日：2015-01-20
• [EN] MULTIKINASE INHIBITORS FOR USE IN THE TREATMENT OF CANCER<br/>[FR] INHIBITEURS MULTIKINASE À UTILISER DANS LE TRAITEMENT DU CANCER
  申请人：EISAI R&D MAN CO LTD

  公开号：WO2009015368A2

  公开（公告）日：2009-01-29

  The present invention provides compounds, pharmaceutical compositions and methods for the treatment of specific cancers. Such compositions may generally comprise a compound of formula (I): wherein R1-R3 are as defined herein, or pharmaceutically acceptable salts or esters thereof; and a pharmaceutically acceptable carrier.