N2-[(4-Phenoxyphenyl)sulfonyl]-D-arginine methyl ester | 549547-45-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N2-[(4-Phenoxyphenyl)sulfonyl]-D-arginine methyl ester
• 英文别名: methyl (2R)-5-(diaminomethylideneamino)-2-[(4-phenoxyphenyl)sulfonylamino]pentanoate
• CAS: 549547-45-7
• 化学式: C₁₉H₂₄N₄O₅S
• 分子量: 420.5
• InChiKey: NNCGPSSYOCUJCZ-QGZVFWFLSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  29
• 可旋转键数：
  11
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.26
• 拓扑面积：
  155
• 氢给体数：
  3
• 氢受体数：
  7

文献信息

• Human adam-10 inhibitors
  申请人：Brown S. David

  公开号：US20090143386A1

  公开（公告）日：2009-06-04

  The present invention provides compounds useful for inhibiting the ADAM-10 protein. Such compounds are useful in the in vitro study of the role of ADAM-10 (and its inhibition) in biological processes. The present invention also comprises pharmaceutical compositions comprising one or more ADAM-10 inhibitors according to the invention in combination with a pharmaceutically acceptable carrier. Such compositions are useful for the treatment of cancer, arthritis, and diseases related to angiogenesis. Correspondingly, the invention also comprises methods of treating forms of cancer, arthritis, and diseases related to angiogenesis in which ADAM-10 plays a critical role. The invention also provides methods for making bis-aryl ether sulfonyl chlorides and ADAM-10 modulators therefrom.

  本发明提供了用于抑制ADAM-10蛋白的化合物。这些化合物在体外研究ADAM-10（及其抑制）在生物过程中的作用方面非常有用。本发明还包括与一种或多种本发明的ADAM-10抑制剂结合的药学上可接受的载体组成的制药组合物。这样的组合物在治疗癌症、关节炎和与血管生成相关的疾病方面非常有用。相应地，本发明还包括治疗癌症、关节炎和与血管生成相关的疾病的方法，其中ADAM-10发挥关键作用。本发明还提供制备双芳基醚磺酰氯和ADAM-10调节剂的方法。
• US7498358B2
  申请人：——

  公开号：US7498358B2

  公开（公告）日：2009-03-03
• US7951972B2
  申请人：——

  公开号：US7951972B2

  公开（公告）日：2011-05-31
• [EN] HUMAN ADAM-10 INHIBITORS<br/>[FR] INHIBITEURS DE L'ADAM-10 HUMAINE
  申请人：EXELIXIS INC

  公开号：WO2003051825A1

  公开（公告）日：2003-06-26

  The present invention provides compounds useful for inhibiting the ADAM-10 protein. Such compounds are useful in the in vitro study of the role of ADAM-10 (and its inhibition) in biological processes. The present invention also comprises pharmaceutical compositions comprising one or more ADAM-10 inhibitors according to the invention in combination with a pharmaceutically acceptable carrier. Such compositions are useful for the treatment of cancer, arthritis, and diseases related to angiogenesis. Correspondingly, the invention also comprises methods of treating forms of cancer, arthritis, and diseases related to angiogenesis in which ADAM-10 plays a critical role. The invention also provides methods for making bis-aryl ether sulfonyl chorides and ADAM-10 modulators therefrom.