4-[N-(1-t-butyloxycarbonylpiperidin-4-yl)-N-methyl]amino-1-(3'-trifluoromethylbenzenesulfonyl)-1H-indole | 1131452-52-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-[N-(1-t-butyloxycarbonylpiperidin-4-yl)-N-methyl]amino-1-(3'-trifluoromethylbenzenesulfonyl)-1H-indole
• 英文别名: Tert-butyl 4-[methyl-[1-[3-(trifluoromethyl)phenyl]sulfonylindol-4-yl]amino]piperidine-1-carboxylate
• CAS: 1131452-52-2
• 化学式: C₂₆H₃₀F₃N₃O₄S
• 分子量: 537.603
• InChiKey: PHGBVPGVOLJNGL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.7
• 重原子数：
  37
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  80.2
• 氢给体数：
  0
• 氢受体数：
  8

文献信息

• [EN] SUBSTITUTED INDOLYL COMPOUNDS AND THEIR USE AS 5-HT6 LIGANDS<br/>[FR] COMPOSÉS INDOLYLE SUBSTITUÉS ET LEUR UTILISATION EN TANT QUE LIGANDS DE 5-HT6
  申请人：SUVEN LIFE SCIENCES LTD

  公开号：WO2009034581A1

  公开（公告）日：2009-03-19

  The present invention relates to novel substituted indolyl compounds of formula (I), their derivatives, their stereoisomers, their pharmaceutically acceptable salts and pharmaceutically acceptable compositions containing them. The present invention also relates to a process for the preparation of above said novel compounds, their derivatives, their stereoisomers, their pharmaceutically acceptable salts and pharmaceutically acceptable compositions containing them. This invention also relates to the novel intermediates involved therein and process of their preparation. These compounds are useful in the treatment of various disorders that are related to 5-HT6 receptor functions.

  本发明涉及公式（I）的新型取代吲哚基化合物，其衍生物，其立体异构体，其药学上可接受的盐和含有它们的药学上可接受的组合物。本发明还涉及上述新型化合物，其衍生物，其立体异构体，其药学上可接受的盐和含有它们的药学上可接受的组合物的制备方法。本发明还涉及其中涉及的新型中间体及其制备方法。这些化合物在治疗与5-HT6受体功能相关的各种疾病中有用。