3-[(4-(3,3-difluoropiperidin-1-yl)-1,3,5-triazin-2-yl)amino]-benzenemethanesulfonamide | 1396707-52-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: 3-[(4-(3,3-difluoropiperidin-1-yl)-1,3,5-triazin-2-yl)amino]-benzenemethanesulfonamide
• 英文别名: [3-[[4-(3,3-Difluoropiperidin-1-yl)-1,3,5-triazin-2-yl]amino]phenyl]methanesulfonamide
• CAS: 1396707-52-0
• 化学式: C₁₅H₁₈F₂N₆O₂S
• 分子量: 384.41
• InChiKey: YAPHIQWZVQIIIR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  26
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  123
• 氢给体数：
  2
• 氢受体数：
  10

文献信息

• [EN] PHARMACEUTICALLY ACTIVE DISUBSTITUTED TRIAZINE DERIVATIVES<br/>[FR] DÉRIVÉS DE TRIAZINE DISUBSTITUÉS PHARMACEUTIQUEMENT ACTIFS
  申请人：LEAD DISCOVERY CENTER GMBH

  公开号：WO2012117048A1

  公开（公告）日：2012-09-07

  The present invention relates to disubstituted triazine derivatives and/or pharmaceutically acceptable salts thereof, the use of these derivatives as pharmaceutically active agents, especially for the prophylaxis and/or treatment of infectious diseases, including opportunistic diseases, immunological diseases, autoimmune diseases, cardiovascular diseases, cell proliferative diseases, inflammation, erectile dysfunction and stroke, and pharmaceutical compositions containing at least one of said disubstituted triazine derivatives and/or pharmaceutically acceptable salts thereof. Furthermore, the present invention relates to the use of said disubstituted triazine derivatives as inhibitors for a protein kinase.

  本发明涉及二取代三嗪衍生物和/或其药用可接受盐，这些衍生物作为药用活性剂的使用，特别用于预防和/或治疗传染病，包括机会性疾病、免疫疾病、自身免疫疾病、心血管疾病、细胞增殖性疾病、炎症、勃起功能障碍和中风，以及含有至少一种所述二取代三嗪衍生物和/或其药用可接受盐的药物组合物。此外，本发明涉及所述二取代三嗪衍生物作为蛋白激酶抑制剂的使用。
• PHARMACEUTICALLY ACTIVE DISUBSTITUTED TRIAZINE DERIVATIVES
  申请人：Rühter Gerd

  公开号：US20140179662A1

  公开（公告）日：2014-06-26

  The present invention relates to disubstituted triazine derivatives and/or pharmaceutically acceptable salts thereof, the use of these derivatives as pharmaceutically active agents, especially for the prophylaxis and/or treatment of infectious diseases, including opportunistic diseases, immunological diseases, autoimmune diseases, cardiovascular diseases, cell proliferative diseases, inflammation, erectile dysfunction and stroke, and pharmaceutical compositions containing at least one of said disubstituted triazine derivatives and/or pharmaceutically acceptable salts thereof. Furthermore, the present invention relates to the use of said disubstituted triazine derivatives as inhibitors for a protein kinase.

  本发明涉及二取代三嗪衍生物和/或其药学上可接受的盐，这些衍生物作为药物活性剂的用途，特别是用于预防和/或治疗感染性疾病，包括机会性疾病、免疫性疾病、自身免疫性疾病、心血管疾病、细胞增殖性疾病、炎症、勃起功能障碍和中风，以及含有至少一种上述二取代三嗪衍生物和/或其药学上可接受的盐的制药组合物。此外，本发明涉及将上述二取代三嗪衍生物用作蛋白激酶抑制剂。
• US9226929B2
  申请人：——

  公开号：US9226929B2

  公开（公告）日：2016-01-05