(S)-N-{3-[4-(6-(4-hydroxy-piperidin-1-yl)-pyridin-3-yl)-3-fluorophenyl]-2-oxo-oxazolidin-5-ylmethyl}-acetamide | 380382-25-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: (S)-N-{3-[4-(6-(4-hydroxy-piperidin-1-yl)-pyridin-3-yl)-3-fluorophenyl]-2-oxo-oxazolidin-5-ylmethyl}-acetamide
• 英文别名: (S)-[N-3-(4-(2-(4-hydroxypiperidin-1-yl)pyridin-5-yl)-3-fluorophenyl)-2-oxo-5-oxazolidinyl]methyl acetamide；N-[[(5S)-3-[3-fluoro-4-[6-(4-hydroxypiperidin-1-yl)pyridin-3-yl]phenyl]-2-oxo-1,3-oxazolidin-5-yl]methyl]acetamide
• CAS: 380382-25-2
• 化学式: C₂₂H₂₅FN₄O₄
• 分子量: 428.463
• InChiKey: PEHLFCNFCRRJLY-SFHVURJKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  31
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.41
• 拓扑面积：
  95
• 氢给体数：
  2
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  (S)-N-{3-[4-(6-(4-hydroxy-piperidin-1-yl)-pyridin-3-yl)-3-fluorophenyl]-2-oxo-oxazolidin-5-ylmethyl}-acetamide 、 甲基磺酰氯 在 三乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 1.0h， 以91%的产率得到(S)-N-{3-[4-(6-(4-methanesulfonyloxypiperidin-1-yl)-pyridin-3-yl)-3-fluorophenyl]-2-oxo-oxazolidin-5-ylmethyl}-acetamide
  参考文献：
  名称：

  WO2007/23507

  摘要：

  公开号：
• 作为产物：
  描述：

  (S)-N-{3-[4-(6-(4-oxopiperidin-1-yl)-pyridin-3-yl)-3-fluorophenyl]-2-oxo-oxazolidin-5-ylmethyl}-acetamide 在 sodium tetrahydroborate 、 水 作用下， 以 甲醇 为溶剂， 反应 1.0h， 以87%的产率得到(S)-N-{3-[4-(6-(4-hydroxy-piperidin-1-yl)-pyridin-3-yl)-3-fluorophenyl]-2-oxo-oxazolidin-5-ylmethyl}-acetamide
  参考文献：
  名称：

  WO2007/23507

  摘要：

  公开号：

文献信息

• Novel oxazolidinone derivatives and a process for the preparation thereof
  申请人：——

  公开号：US20030166620A1

  公开（公告）日：2003-09-04

  The present invention relates to novel oxazolidinone derivatives, their pharmaceutically acceptable salts and a process for the preparation thereof. More particularly, the present invention relates to oxazolidinone derivatives having pyridine or pyrimidine moeity substituted by heterocycle and heteroaromaticcycle at 4-position of phenyl ring. The compounds of the present invention have wide antibacterial spectrum, superior antibacterial activity and low toxicity, such that the compound of this invention can be used as an antibacterial agent.

  本发明涉及新颖的噁唑烷酮衍生物，其药用盐以及其制备方法。更具体地，本发明涉及在苯环的4位被杂环和杂芳环取代的噁唑烷酮衍生物。本发明的化合物具有广泛的抗菌谱、优越的抗菌活性和低毒性，因此本发明的化合物可用作抗菌剂。
• [EN] NOVEL OXAZOLIDINONE DERIVATIVES AND A PROCESS FOR THE PREPARATION THEREOF<br/>[FR] NOUVEAUX DERIVES OXAZOLIDINONE ET PROCESSUS DE PREPARATION DE CES DERIVES
  申请人：DONG A PHARM CO LTD

  公开号：WO2001094342A1

  公开（公告）日：2001-12-13

  The present invention relates to novel oxazolidinone derivatives, their pharmaceutically acceptable salts and a process for the preparation thereof. More particularly, the present invention relates to oxazolidinone derivatives having pyridine or pyrimidine moeity substituted by heterocycle and heteroaromaticcycle at 4-position of phenyl ring. The compounds of the present invention have wide antibacterial spectrum, superior antibacterial activity and low toxicity, such that the compound of this invention can be used as an antibacterial agent.

  本发明涉及新型噁唑烷衍生物，其药学上可接受的盐以及其制备方法。更具体地说，本发明涉及在苯环的4位上以杂环和杂芳环取代的吡啶或嘧啶基团的噁唑烷衍生物。本发明的化合物具有广泛的抗菌谱、优越的抗菌活性和低毒性，因此本发明的化合物可用作抗菌剂。
• Oxazolidinones Bearing Antimicrobial Activity Composition and Methods of Preparation
  申请人：Sindkhedkar Milind D

  公开号：US20090018123A1

  公开（公告）日：2009-01-15

  The present invention concerns recombinant DNA's comprising cDNA of genomic RNA of a Salmonidae alphavirus preceded by a spacer sequence, under the control of a suitable promoter. Said recombinant DNA's are useful for obtaining expression vectors, producing recombinant Salmonidae alphavirus, and for obtaining vaccines.

  本发明涉及重组DNA，包括一个Salmonidae alphavirus的基因组RNA的cDNA，其前面有一个间隔序列，在适当的启动子控制下。这些重组DNA对于获得表达载体、产生重组的Salmonidae alphavirus以及获得疫苗非常有用。
• NOVEL OXAZOLIDINONE DERIVATIVES AND A PROCESS FOR THE PREPARATION THEREOF
  申请人：Dong A Pharmaceutical Co. Ltd.

  公开号：EP1289984A1

  公开（公告）日：2003-03-12
• EP1289984A4
  申请人：——

  公开号：EP1289984A4

  公开（公告）日：2004-11-24