N,N-Dimethyl-N'-[2-hydroxy-3-(1-piperidinyl)-propoxy]-N"-phenyl-guanidine Hydrochloride | 191159-93-0

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: N,N-Dimethyl-N'-[2-hydroxy-3-(1-piperidinyl)-propoxy]-N"-phenyl-guanidine Hydrochloride
• 英文别名: N,N-Dimethyl-N'-[2-hydroxy-3-(1-piperidinyl)-propoxy]-N''-phenyl-guanidine Hydrochloride；3-(2-hydroxy-3-piperidin-1-ylpropoxy)-1,1-dimethyl-2-phenylguanidine;hydrochloride
• CAS: 191159-93-0
• 化学式: C₁₇H₂₈N₄O₂*ClH
• 分子量: 356.896
• InChiKey: KWSJFTJPSLIAEH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.22
• 重原子数：
  24
• 可旋转键数：
  8
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.59
• 拓扑面积：
  60.3
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  N,N-dimethyl-N'-phenyl-chloroformamidine 、 O-(2-hydroxy-3-piperidino-propyl)-hydroxylamine 在 盐酸 、 sodium carbonate 作用下， 以 乙酸乙酯 、 丙酮 为溶剂， 以674 mg (28%)的产率得到N,N-Dimethyl-N'-[2-hydroxy-3-(1-piperidinyl)-propoxy]-N"-phenyl-guanidine Hydrochloride
  参考文献：
  名称：

  Use of hydroxylamine derivatives, and method and preparations for increasing the tolerance of field crops against weather stresses

  摘要：

  本发明涉及使用羟胺衍生物的一般式(I)，其中R1代表苯基、N-杂环基、S-杂环基或萘基，其中任何一个可能未取代或取代，未取代或取代的苯氨基或烷基氨基或较低的烷氧基；X代表卤素、氨基或未取代或取代的苯氨基基团，或取代一或两个较低的烷基或羟基的氨基，但如果R1代表未取代或取代的苯氨基、烷基氨基或较低烷氧基，则X不是卤素；Y代表氢、羟基或脂肪酰氧基，但同时R1不能表示苯基、卤苯基、烷氧基苯基、N-杂环基或萘基，X不能表示卤素、羟基或氨基，Y不能表示氢或羟基；R2和R3相互独立地代表氢或较低的烷基，但要求R2和R3不能同时为氢，或者R2和R3与相邻的氮原子一起形成5-至7-成员的饱和杂环，以提高栽培植物对天气条件胁迫，如寒冷、霜冻和干旱的耐受性。

  公开号：

  US20010051630A1

文献信息

• Hydroxylamine derivatives useful for enhancing the molecular chaperon production and the preparation thereof
  申请人：Biorex Research & Development Co.

  公开号：US06653326B1

  公开（公告）日：2003-11-25

  A method of increasing expression of a molecular chaperon by a cell and/or enhancing the activity of a molecular chaperon in cells is provided. The method comprises treating a cell that is exposed to a physiological stress which induces expression of a molecular chaperon by the cell with an effective amount of a certain hydroxylamine derivative to increase the stress. Alternatively; an hydroxylamine derivative can be administrated to a cell before it is exposed to a physiological stress which induces expression of a molecular chaperon by the cell. Preferably, the cell to which an hydroxylamine derivative is administered is an eukaryotic cell. The hydroxylamine derivative corresponds to the formulae (I) or (II). The invention also provides novel hydroxyl amine derivatives falling within the scope of the formulae (I) and (II) as well as pharmaceutical and/or cosmetical compositions comprising the said compounds.

  提供了一种通过细胞增加分子伴侣的表达和/或增强细胞中分子伴侣活性的方法。该方法包括将暴露于诱导细胞表达分子伴侣的生理应激的细胞用有效量的某种羟胺衍生物进行处理，以增加应激。或者；可以在细胞暴露于诱导细胞表达分子伴侣的生理应激之前向细胞施加羟胺衍生物。最好，施加羟胺衍生物的细胞是真核细胞。羟胺衍生物对应于式（I）或（II）。本发明还提供了新颖的羟胺衍生物，属于式（I）和（II）范围内，以及包含所述化合物的药用和/或化妆品组合物。
• Method of enhancing cellular production of molecular chaperon, hydroxylamine derivatives useful for enhancing the chaperon production and the preparation thereof
  申请人：Biorex Research & Development Co.

  公开号：US20040067940A1

  公开（公告）日：2004-04-08

  A method of increasing expression of a molecular chaperon by a cell and/or enhancing the activity of a molecular chaperon in cells is provided. The method comprises treating a cell that is exposed to a physiological stress which induces expression of a molecular chaperon by the cell with an effective amount of a certain hydroxylamine derivative to increase the stress. Alternatively, an hydroxylamine derivative can be administrated to a cell before it is exposed to a physiological stress which induces expression of a molecular chaperon by the cell. Preferably, the cell to which an hydroxylamine derivative is administered is an eukaryotic cell. The hydroxylamine derivative corresponds to the formulae (I) or (II). The invention also provides novel hydroxylamine derivatives falling within the scope of the formulae (I) and (II) as well as pharmaceutical and/or cosmetical compositions comprising the said compounds.

  提供了一种通过细胞增加分子伴侣表达和/或增强细胞中分子伴侣活性的方法。该方法包括使用一定量的某种羟胺衍生物处理受到诱导细胞分子伴侣表达的生理应激的细胞，以增加应激。或者，在细胞暴露于诱导其表达分子伴侣的生理应激之前，可以向细胞施用羟胺衍生物。最好，施用羟胺衍生物的细胞是真核细胞。羟胺衍生物对应于式(I)或(II)。该发明还提供了落在式(I)和(II)范围内的新羟胺衍生物，以及包含上述化合物的药物和/或化妆品组合物。
• Method of enhancing cellular production of molecular chaperone, hydroxylamine derivatives useful for enhancing the chaperone production and the preparation thereof
  申请人：CytRx Corporation

  公开号：US07745465B2

  公开（公告）日：2010-06-29

  A method of increasing expression of a molecular chaperon by a cell and/or enhancing the activity of a molecular chaperon in cells is provided. The method comprises treating a cell that is exposed to a physiological stress which induces expression of a molecular chaperon by the cell with an effective amount of a certain hydroxylamine derivative to increase the stress. Alternatively, an hydroxylamine derivative can be administrated to a cell before it is exposed to a physiological stress which induces expression of a molecular chaperon by the cell. Preferably, the cell to which an hydroxylamine derivative is administered is an eukaryotic cell. The hydroxylamine derivative corresponds to the formulae (I) or (II). The invention also provides novel hydroxylamine derivatives falling within the scope of the formulae (I) and (II) as well as pharmaceutical and/or cosmetical compositions comprising the said compounds.

  提供了一种通过细胞增加分子伴侣的表达和/或增强细胞中分子伴侣活性的方法。该方法包括使用一定量的某种羟胺衍生物处理暴露于诱导细胞分子伴侣表达的生理应激下的细胞，以增加压力。另外，可以在细胞暴露于诱导细胞分子伴侣表达的生理应激之前给细胞施加羟胺衍生物。最好，接受羟胺衍生物处理的细胞是真核细胞。羟胺衍生物对应于公式（I）或（II）。本发明还提供了落在公式（I）和（II）范围内的新型羟胺衍生物，以及包含所述化合物的药物和/或化妆品组合物。
• METHOD OF ENHANCING CELLULAR PRODUCTION OF MOLECULAR CHAPERONE, HYDROXYLAMINE DERIVATIVES USEFUL FOR ENHANCING THE CHAPERONE PRODUCTION AND THE PREPARATION THEREOF
  申请人：Vígh László

  公开号：US20100267711A1

  公开（公告）日：2010-10-21

  A method of increasing expression of a molecular chaperon by a cell and/or enhancing the activity of a molecular chaperon in cells is provided. The method comprises treating a cell that is exposed to a physiological stress which induces expression of a molecular chaperon by the cell with an effective amount of a certain hydroxylamine derivative to increase the stress. Alternatively, an hydroxylamine derivative can be administrated to a cell before it is exposed to a physiological stress which induces expression of a molecular chaperon by the cell. Preferably, the cell to which an hydroxylamine derivative is administered is an eukaryotic cell. The hydroxylamine derivative corresponds to the formulae (I) or (II). The invention also provides novel hydroxylamine derivatives falling within the scope of the formulae (I) and (II) as well as pharmaceutical and/or cosmetical compositions comprising the said compounds.

  本发明提供了一种通过细胞增加分子伴侣的表达和/或增强细胞中分子伴侣活性的方法。该方法包括使用一定量的某种羟胺衍生物处理受到诱导细胞分子伴侣表达的生理应激的细胞，以增加应激。或者，在细胞暴露于诱导其表达分子伴侣的生理应激之前，可以向细胞中注入羟胺衍生物。最好，接受羟胺衍生物处理的细胞是真核细胞。羟胺衍生物对应于公式（I）或（II）。本发明还提供了落在公式（I）和（II）范围内的新羟胺衍生物，以及包含该化合物的药物和/或化妆品组合物。
• HYDROXYLAMINE DERIVATIVES USEFUL FOR ENHANCING THE MOLECULAR CHAPERON PRODUCTION AND THE PREPARATION THEREOF
  申请人：BIOREX KUTATO ES FEJLESZTÖ RT.

  公开号：EP0801649B1

  公开（公告）日：2002-08-07