2-Fluoro-4-(methylaminomethyl)aniline | 1343264-40-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-Fluoro-4-(methylaminomethyl)aniline
• CAS: 1343264-40-3
• 化学式: C₈H₁₁FN₂
• 分子量: 154.187
• InChiKey: DKNVGZHWHLKEQE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  38
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2,5-二氟-3-甲酰基-苯甲酸甲酯 、 2-Fluoro-4-(methylaminomethyl)aniline 以 乙醇 为溶剂， 生成
  参考文献：
  名称：

  Synthesis and biological evaluation of substituted 2-phenyl-2H-indazole-7-carboxamides as potent poly(ADP-ribose) polymerase (PARP) inhibitors

  摘要：

  A potent series of substituted 2-phenyl-2H-indazole-7-carboxamides were synthesized and evaluated as inhibitors of poly (ADP-ribose) polymerase (PARP). This extensive SAR exploration culminated with the identification of substituted 5-fluoro-2-phenyl-2H-indazole-7-carboxamide analog 48 which displayed excellent PARP enzyme inhibition with IC(50) = 4 nM, inhibited proliferation of cancer cell lines deficient in BRCA-1 with CC(50) = 42 nM and showed encouraging pharmacokinetic properties in rats compared to the lead 6. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2009.11.127

文献信息

• SPLICEOSTATIN ANALOGS AND METHODS FOR THEIR PREPARATION
  申请人：PFIZER INC.

  公开号：US20140134193A1

  公开（公告）日：2014-05-15

  The present invention is directed to novel cytotoxic spliceostatin analogs and derivatives, to antibody drug conjugates thereof, and to methods for using the same to treat medical conditions including cancer.

  本发明涉及新型细胞毒性剪接素类似物和衍生物，其抗体药物偶联物，以及使用它们治疗包括癌症在内的医学状况的方法。
• 2-ALKYNYL-AND 2-ALKENYL-PYRAZOLO- [4,3-E ] -1,2,4-TRIAZOLO- [1,5-C] -PYRIMIDINE ADENOSINE A2A RECEPTOR ANTAGONISTS
  申请人：Schering Corporation

  公开号：EP1622912B1

  公开（公告）日：2009-05-27
• PYRAZOLO[4,3-E]-1,2,4-TRIAZOLO[1,5-C]PYRIMIDINE ADENOSINE-A2A- RECEPTOR ANTAGONISTS
  申请人：Schering Corporation

  公开号：EP1745047B1

  公开（公告）日：2010-03-24
• SPLICEOSTATIN ANALOGS
  申请人：Pfizer Inc.

  公开号：EP2917195B9

  公开（公告）日：2018-05-30
• SPLICEOSTATIN ANALOGS AND METHOS FOR THEIR PREPARATION
  申请人：PFIZER INC.

  公开号：US20170014523A1

  公开（公告）日：2017-01-19

  The present invention is directed to novel cytotoxic spliceostatin analogs and derivatives, to antibody drug conjugates thereof, and to methods for using the same to treat medical conditions including cancer.