2-[2,3-Dichloro-4-(2-methylene-butyryl)-phenoxy]-acetamide | 6463-19-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-[2,3-Dichloro-4-(2-methylene-butyryl)-phenoxy]-acetamide
• 英文别名: 2-[2,3-Dichloro-4-(2-methylidenebutanoyl)phenoxy]acetamide
• CAS: 6463-19-0
• 化学式: C₁₃H₁₃Cl₂NO₃
• 分子量: 302.157
• InChiKey: QQXZOCLGQNUZGU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  19
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.23
• 拓扑面积：
  69.4
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• METHOD OF PREPARING ETHACRYNIC AMIDE DERIVATIVES AND APPLICATION THEREOF
  申请人：National Tsing Hua University

  公开号：US20130156701A1

  公开（公告）日：2013-06-20

  The present invention provides a method for preparing [ 18 F]—N-(4-fluorobutyl)ethacrynic amide which is prepared from radiofluorination and deprotection of the precursor tosylate N-Boc-N-[4-(toluenesulfonyloxy)-butyl)ethacrynic amide], obtained from ethacrynic acid via 6-step synthesis in 39% yield, in a radiochemical yield of 44%, aspecific activity of 48 GBq/μmol and radiochemical purity of 98%. The present invention further provides a composition for positron emission tomography (PET) of an animal models of a tumor liver or a liver disease, comprising [ 18 F]—N-(4-fluorobutyl)ethacrynic amide and a pharmaceutically acceptable carrier.

  本发明提供了一种制备[18F]-N-(4-氟丁基)乙丙烯酰胺的方法，该方法是通过对前体对甲苯磺酸酯N-Boc-N-[4-(甲苯磺酰氧基)-丁基）乙丙烯酰胺进行放射氟化和脱保护而制备的，该前体是从乙丙烯酸经过6步合成得到，收率为39%，放射化学收率为44%，比活度为48GBq/μmol，放射化学纯度为98%。本发明还提供了一种用于肿瘤肝脏或肝脏疾病动物模型的正电子发射断层扫描（PET）的组合物，包括[18F]-N-(4-氟丁基)乙丙烯酰胺和一种药用可接受载体。
• CONSTRUCTION AND SCREENING OF SOLUTION-PHASE DERIVED LIBRARY OF FENBUFEN AND ETHACRYNIC ACID
  申请人：Yu Chung-Shan

  公开号：US20110306668A1

  公开（公告）日：2011-12-15

  A process for synthesizing and screening solution phase derived libraries of fenbufen and ethacrynic acid is provided in the present invention. Compounds in the present invention having cytotoxicities are useful for a variety of therapeutic applications.

  本发明提供了一种合成和筛选溶液相衍生的芬布芬和依他克酸库的过程。本发明中具有细胞毒性的化合物对多种治疗应用是有用的。
• Small-Molecule-Targeted Protein Degradation
  申请人：Hedstrom Lizbeth K.

  公开号：US20130190340A1

  公开（公告）日：2013-07-25

  Certain aspects of the invention relate to compounds, compositions and methods that are useful for treating or preventing a disease in a subject by enhancing the degradation of a protein. In other aspects, said compounds can be useful research tools for investigating protein degradation. In other aspects, said compounds are useful research tools for investigating protein function. In certain embodiments, the degraded protein is implicated in a disease or disorder whose pathology is related at least in part to the excessive expression of the protein or the expression of a mutant form of the protein.

  该发明的某些方面涉及化合物、组合物和方法，通过增强蛋白质降解来治疗或预防主体中的疾病。在其他方面，这些化合物可以用于研究蛋白质降解的研究工具。在其他方面，这些化合物是用于研究蛋白质功能的有用工具。在某些实施例中，被降解的蛋白质与疾病或障碍有关，其病理学与蛋白质的过度表达或突变形式的表达至少部分相关。
• MOLECULAR SENSOR AND METHODS OF USE THEREOF
  申请人：YEDA RESEARCH AND DEVELOPMENT CO. LTD.

  公开号：US20150276753A1

  公开（公告）日：2015-10-01

  The present invention is directed to fluorescent molecular sensor based on Thiazole Orange for protein detection. Interaction of the protein target with the molecular sensors of this invention results in a significant increase in the fluorescence emission. The generation of light output signal enables one to detect protein biomarkers associated with different diseases or detecting the protein of interest also in living cells.

  本发明涉及一种基于Thiazole Orange的荧光分子传感器，用于蛋白质检测。本发明的分子传感器与蛋白质靶标的相互作用导致荧光发射显著增加。光输出信号的产生使得人们能够检测与不同疾病相关的蛋白质生物标志物或者在活细胞中检测感兴趣的蛋白质。
• Molecular sensor and methods of use thereof
  申请人：YEDA RESEARCH AND DEVELOPMENT CO. LTD.

  公开号：US10557853B2

  公开（公告）日：2020-02-11

  The present invention is directed to fluorescent molecular sensor based on Thiazole Orange for protein detection. Interaction of the protein target with the molecular sensors of this invention results in a significant increase in the fluorescence emission. The generation of light output signal enables one to detect protein biomarkers associated with different diseases or detecting the protein of interest also in living cells.

  本发明涉及基于噻唑橙的用于蛋白质检测的荧光分子传感器。蛋白质目标与本发明的分子传感器相互作用后，荧光发射会显著增加。光输出信号的产生使人们能够检测与不同疾病相关的蛋白质生物标记物，或在活细胞中检测感兴趣的蛋白质。