2''-Hydroxy-2'-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)-[1,1',4',1'']terphenyl-4''-carboxylic acid | 220950-73-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2''-Hydroxy-2'-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)-[1,1',4',1'']terphenyl-4''-carboxylic acid
• 英文别名: 2"-hydroxy-2'-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-2-naphthyl)-[1,1';4',1"]terphenyl-4"-carboxylic acid；2"-Hydroxy-2'-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl) [1,1',4',1"]terphenyl-4"-carboxylic acid；3-Hydroxy-4-[4-phenyl-3-(5,5,8,8-tetramethyl-6,7-dihydronaphthalen-2-yl)phenyl]benzoic acid
• CAS: 220950-73-2
• 化学式: C₃₃H₃₂O₃
• 分子量: 476.615
• InChiKey: POIMLIGCHZLSNU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  9.1
• 重原子数：
  36
• 可旋转键数：
  4
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  57.5
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• Biphenyl derivatives substituted with an aromatic or heteroaromatic radical, and pharmaceutical and cosmetic compositions containing them
  申请人：Galderma Research & Development

  公开号：US20040030141A1

  公开（公告）日：2004-02-12

  Compounds of formula (I): 1 in which: Ar represents an aromatic or a heteroaromatic radical optionally substituted, in particular, with an alkyl or a carboxyl group, R 2 and R 3 represent, in particular, H or alkyl, or R 2 and R 3 , taken together, form a 5- or 6-membered ring, R 4 and R 5 represent, in particular, H or halogen, R 6 represents, in particular, H or lower alkyl, and the salts of the compounds of formula (I). These compounds can be used in particular in the treatment of dermatological complaints associated with a keratinization disorder, and for combating ageing of the skin.

  化合物的公式（I）：其中：Ar代表芳香或杂环基团，可选地取代，特别是用烷基或羧基取代，R2和R3代表特别是氢或烷基，或R2和R3一起形成5或6元环，R4和R5代表特别是氢或卤素，R6代表特别是氢或低烷基，以及化合物的盐。这些化合物可以特别用于治疗与角化障碍相关的皮肤疾病，并用于抗皮肤衰老。
• Retinoid compounds suited for antibacterial applications
  申请人：——

  公开号：US20030055110A1

  公开（公告）日：2003-03-20

  A variety of retinoid compounds well suited for preventively or curatively treating a bacterial colonization infesting/infecting an individual subject exhibit pronounced antibacterial activity, notably pronounced antibacterial activity in respect of the bacterium Staphylococcus aureus , and are also well suited for the cleansing/deodorizing of human skin.

  一系列适合于预防或治疗细菌感染的视黄醇类化合物表现出显著的抗菌活性，特别是对于金黄色葡萄球菌这种细菌表现出显著的抗菌活性，并且也适合于清洁/除臭人类皮肤。
• Inosine compounds and their use for treating or preventing an inflamation or a reperfusion disease
  申请人：Inotek Pharmaceuticals Corporation

  公开号：US20030040502A1

  公开（公告）日：2003-02-27

  Inosine compounds, compositions comprising an inosine compound and methods for treating or preventing an inflammation disease or a reperfusion disease comprising administering an effective amount of an inosine compound to a patient in need thereof are disclosed.

  本发明揭示了肌苷化合物、包含肌苷化合物的组合物以及治疗或预防炎症疾病或再灌注疾病的方法，其中将有效量的肌苷化合物给予需要治疗的患者。
• Inosine compounds and their use for treating or preventing an inflammation or reperfusion disease
  申请人：Salzman L. Andrew

  公开号：US20050014715A1

  公开（公告）日：2005-01-20

  Inosine compounds, compositions comprising an inosine compound and methods for treating or preventing an inflammation disease or a reperfusion disease comprising administering an effective amount of an inosine compound to a patient in need thereof are disclosed.

  本发明公开了肌苷化合物、包含肌苷化合物的组合物以及治疗或预防炎症疾病或再灌注疾病的方法，这些方法包括向有需要的患者施用有效量的肌苷化合物。
• Targeted ligands
  申请人：Herman William

  公开号：US20050118164A1

  公开（公告）日：2005-06-02

  The invention contemplates a composition containing a multispecific ligand containing at least a first ligand binding moiety and a second ligand binding moiety. The first ligand binding moiety specifically binds with a pre-selected first affinity to at least a first ligand. The first ligand has a first biodistribution. The second ligand binding moiety specifically binds with a pre-selected affinity to at least a second ligand. The second ligand has a second biodistribution. The affinity of first and second ligand binding moieties arc selected to bias the biodistribution of the multispecific ligand in favour of a selected location of one or both of the ligands.

  本发明设想了一种含有多特异性配体的组合物，该配体至少含有第一配体结合分子和第二配体结合分子。第一配体结合分子以预选的第一亲和力与至少第一配体特异性结合。第一配体具有第一生物分布。第二配体结合基团以预选的亲和力与至少一种第二配体特异性结合。第二配体具有第二生物分布。第一配体和第二配体结合分子的亲和力经过选择，使多特异性配体的生物分布偏向于其中一种或两种配体的选定位置。