2-fluorenylnitrene | 188241-65-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 芴
• 英文名称: 2-fluorenylnitrene
• 英文别名: 3,9-Dihydrofluoren-3-ylium-2-ylideneazanide
• CAS: 188241-65-8
• 化学式: C₁₃H₉N
• 分子量: 179.221
• InChiKey: PGUQDOZRYKDPPE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  14
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  2-fluorenylnitrene 以 甲醇 为溶剂， 生成 2-fluorenylnitrenium
  参考文献：
  名称：

  Solvent Effects on Intermolecular Proton Transfer:  The Rates of Nitrene Protonation and Their Correlation with Swain Acity

  摘要：

  The rate of protonation of singlet 2-fluorenylnitrene was studied in eight protic solvents. The protonation rates vary between 10(11) and 10(9) s(-1) and are well-correlated with Swain's acity parameters. This demonstrates that Swain acity parameters and nitrene protonation rates can be used to evaluate bulk solvent acidity.

  DOI：

  10.1021/ol7023086
• 作为产物：
  描述：

  2-叠氮基芴 以 甲醇 为溶剂， 生成 2-fluorenylnitrene
  参考文献：
  名称：

  Solvent Effects on Intermolecular Proton Transfer:  The Rates of Nitrene Protonation and Their Correlation with Swain Acity

  摘要：

  The rate of protonation of singlet 2-fluorenylnitrene was studied in eight protic solvents. The protonation rates vary between 10(11) and 10(9) s(-1) and are well-correlated with Swain's acity parameters. This demonstrates that Swain acity parameters and nitrene protonation rates can be used to evaluate bulk solvent acidity.

  DOI：

  10.1021/ol7023086

文献信息

• Time-Resolved Resonance Raman Spectroscopy and Density Functional Study of 2-Fluorenylnitrene and Its Dehydroazepine Products
  作者：Shing Yau Ong、Peizhi Zhu、Yuen Fan Poon、King Hung Leung、Wei-Hai Fang、David Lee Phillips

  DOI：10.1002/1521-3765(20020503)8:9<2163::aid-chem2163>3.0.co;2-c

  日期：2002.5.3

  not absorb very much at the 416 nm probe wavelength used in the time-resolved resonance Raman experiments. Comparison of the singlet 2-fluorenylnitrene species with the singlet 2-fluorenylnitrenium ion species indicates that protonation of the nitrene to give the nitrenium ion leads to a significant enhancement of the cyclohexadienyl character of the phenyl rings without much change of the C-N bond

  我们报告了2-芴基氮烯在乙腈中光解后获得的2-芴基氮烯及其脱氢氮杂产物的时间分辨共振拉曼光谱。实验性拉曼频带频率与根据UBPW91 / cc-PVDZ密度函数计算的2-芴基单重态和三重态的计算振动频率以及两个脱氢氮杂ring烷扩环产物的BPW91 / cc-PVDZ计算值具有很好的一致性。种类。2-芴基氮烯拉曼信号的衰减和脱氢氮杂庚因产物的出现表明存在一种中间物质（可能是一种叠氮基），该中间物质在时间分辨共振拉曼实验中使用的416 nm探针波长处不会吸收太多。
• INHIBITORS OF POLO-LIKE KINASES
  申请人：ABBOTT LABORATORIES

  公开号：EP2021316A1

  公开（公告）日：2009-02-11
• [EN] INHIBITORS OF POLO-LIKE KINASES<br/>[FR] INHIBITEURS DE LA KINASE DE TYPE POLO
  申请人：ABBOTT LAB

  公开号：WO2007140233A1

  公开（公告）日：2007-12-06

  [EN] Compounds that inhibit Plk1, compositions containing the compounds and methods of treating diseases using the compounds are disclosed.
  [FR] La présente invention concerne des composés qui inhibent Plk1, des compositions contenant les composés et des procédés pour traiter des maladies en utilisant les composés.