1,3,7,9-tetramethyl-5-(p-tolyl)-5,10-dihydropyrido[2,3-d:6,5-d']dipyrimidine-2,4,6,8(1H,3H,7H,9H)-tetraone | 1437307-52-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶并嘧啶类
• 英文名称: 1,3,7,9-tetramethyl-5-(p-tolyl)-5,10-dihydropyrido[2,3-d:6,5-d']dipyrimidine-2,4,6,8(1H,3H,7H,9H)-tetraone
• CAS: 1437307-52-2
• 化学式: C₂₀H₂₁N₅O₄
• 分子量: 395.418
• InChiKey: WTRCDHGAHPDQDZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.03
• 重原子数：
  29.0
• 可旋转键数：
  1.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  100.03
• 氢给体数：
  1.0
• 氢受体数：
  9.0

反应信息

• 作为产物：
  描述：

  1,3-二甲基巴比妥酸 、 1,3-二甲基-6-氨基脲嘧啶 、 对甲基苯甲醛 在 Fe₃O₄/SiO₂-SO₃H 作用下， 以 水 为溶剂， 反应 0.33h， 以95%的产率得到1,3,7,9-tetramethyl-5-(p-tolyl)-5,10-dihydropyrido[2,3-d:6,5-d']dipyrimidine-2,4,6,8(1H,3H,7H,9H)-tetraone
  参考文献：
  名称：

  Nano-Fe3O4 encapsulated-silica particles bearing sulfonic acid groups as a magnetically separable catalyst for green and efficient synthesis of functionalized pyrimido[4,5-b]quinolines and indeno fused pyrido[2,3-d]pyrimidines in water

  摘要：

  The magnetic nanoparticles supported silica sulfuric acid was used as an efficient catalyst for the synthesis of pyrimido[4,5-b]quinolines and indeno fused pyrido[2,3-d]pyrimidines in water. The desired products were obtained in excellent yields. Fe3O4@SiO2-SO3H was readily recovered using an external magnet and could be reused several times without significant loss of reactivity. (C) 2013 Firouzeh Nemati. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.

  DOI：

  10.1016/j.cclet.2013.02.018