2-(1(2)H-tetrazol-5-yl)-pyrrolidine-1-carboxylic acid benzyl ester | 33876-20-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-(1(2)H-tetrazol-5-yl)-pyrrolidine-1-carboxylic acid benzyl ester
• 英文别名: (R)-benzyl 2-(1H-tetrazol-5-yl)pyrrolidine-1-carboxylate；benzyl 2-(2H-tetrazol-5-yl)pyrrolidine-1-carboxylate
• CAS: 33876-20-9
• 化学式: C₁₃H₁₅N₅O₂
• 分子量: 273.294
• InChiKey: WSZJKMUGRXLXDQ-UHFFFAOYSA-N

物化性质

• 熔点：
  84-86 °C
• 沸点：
  488.9±55.0 °C(Predicted)
• 密度：
  1.364±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  20
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  84
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• Reducing Platelet Activation, Aggregation and Platelet-Stimulated Thrombosis or Blood Coagulation by Reducing Mitochondrial Respiration
  申请人：Collman James P.

  公开号：US20110301180A1

  公开（公告）日：2011-12-08

  It has been discovered that inhibiting mitochondrial respiration in platelets reduces platelet activation or platelet aggregation. Certain heterocyclic compounds significantly reduced one or more platelet functions including clumping, sticking or platelet-stimulated clotting. Thus diseases or disorders mediated by inappropriately high levels of platelet activation or platelet aggregation can be treated by administering a therapeutically effective amount of a heterocyclic compound or nonheterocyclic mitochondrial inhibitor that significantly reduces one or more platelet functions including clumping, sticking or platelet-stimulated clotting, preferably in a reversible manner.

  已经发现，在血小板中抑制线粒体呼吸可以减少血小板的激活或血小板聚集。某些杂环化合物显著降低了一个或多个血小板功能，包括凝聚、粘附或血小板刺激的凝血。因此，由血小板激活或血小板聚集水平不当高导致的疾病或疾病可以通过给予一种治疗有效量的杂环化合物或非杂环线粒体抑制剂来治疗，该化合物显著降低了一个或多个血小板功能，包括凝聚、粘附或血小板刺激的凝血，最好是以可逆的方式。
• PDF INHIBITORS
  申请人：Pichota Arkadius

  公开号：US20090318445A1

  公开（公告）日：2009-12-24

  The invention relates to novel compounds that are inhibitors of peptidyl deformylase (PDF). The compounds are useful as antimicrobials and antibiotics. The compounds of the invention display selective inhibition of peptidyl deformylase versus other metalloproteinases such as MMPs. Methods of preparation and uses of the compounds are also disclosed.

  本发明涉及一种新型化合物，它们是肽变形酶（PDF）的抑制剂。这些化合物可用作抗微生物和抗生素。本发明的化合物具有选择性地抑制肽变形酶而不是其他金属蛋白酶，如MMPs。还公开了化合物的制备方法和用途。
• Preparation of Terazole Derivatives
  申请人：Sedelmeier Gottfried

  公开号：US20080200687A1

  公开（公告）日：2008-08-21

  The invention relates to a process for the preparation of (S)-pyrrolidine-1H-tetrazole derivatives of formula wherein R 1 , R 2 and R 3 , independently of one another, represent hydrogen, halogen or an organic radical, in racemic form or as an enantiomer, a tautomer, an analog thereof or a salt thereof.

  本发明涉及一种制备式为（S）-吡咯烷-1H-四唑衍生物的过程，其中R1、R2和R3分别独立地表示氢、卤素或有机基团，以外消旋体形式或对映体、互变异构体、类似物或其盐形式存在。
• PREPARATION OF TERAZOLE DERIVATIVES
  申请人：Sedelmeier Gottfried

  公开号：US20100184991A1

  公开（公告）日：2010-07-22

  The invention relates to a process for the preparation of (S)-pyrrolidine-1H-tetrazole derivatives of formula wherein R 1 , R 2 and R 3 , independently of one another, represent hydrogen, halogen or an organic radical, in racemic form or as an enantiomer, a tautomer, an analog thereof or a salt thereof.

  本发明涉及一种制备(S)-吡咯烷-1H-四唑衍生物的过程，其化学式为 其中R1，R2和R3，各自独立地表示氢、卤素或有机基团，可以是外消旋体或对映体、互变异构体、类似物或其盐。
• US9918964B2
  申请人：——

  公开号：US9918964B2

  公开（公告）日：2018-03-20