3-Carboxymethyl-1-hexylparabanic acid | 128043-85-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑烷类
• 英文名称: 3-Carboxymethyl-1-hexylparabanic acid
• 英文别名: 2-(3-Hexyl-2,4,5-trioxoimidazolidin-1-yl)acetic acid
• CAS: 128043-85-6
• 化学式: C₁₁H₁₆N₂O₅
• 分子量: 256.258
• InChiKey: QDRSZAXUBUWHCF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  18
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.64
• 拓扑面积：
  95
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• Parabanic acid derivatives and pharmaceutical compositions containing them
  申请人：NIPPON ZOKI PHARMACEUTICAL CO. LTD.

  公开号：EP0353198A1

  公开（公告）日：1990-01-31

  The present invention relates to parabanic acid derivatives and pharmaceutically acceptable salts and metal complexes thereof having aldose reductase inhibitory activity. The compounds have the formula The compounds are useful as drugs for the treatment or prevention of diabetic conditions.

  本发明涉及具有醛糖还原酶抑制活性的对位苯甲酸衍生物及其药学上可接受的盐和金属复合物。这些化合物的化学式为 这些化合物可用作治疗或预防糖尿病的药物。
• 3-Deoxyglucosone production inhibitor
  申请人：NIPPON ZOKI PHARMACEUTICAL CO., LTD.

  公开号：EP0855182A1

  公开（公告）日：1998-07-29

  The present invention relates to an inhibitor for the production of 3-deoxyglucosone (3-DG) which contains at least one of parabanic acid derivatives represented by the following formula (I) or pharmaceutically acceptable salts thereof as an effective ingredient    wherein R is hydrogen or lower alkyl; X is hydrogen, alkyl, cycloalkyl, lower alkylcycloalkyl, phenyl or phenylalkyl which is optionally substituted with lower alkyl, lower alkoxy, nitro and/or halogen; and n is an integer of from 1 to 4. The compound of the present invention has an action of inhibiting the production of 3-DG which is a highly active intermediate and participates in a protein crosslinked formation in Maillard reaction and, therefore, said compound is useful in the treatment and the prevention of various diseases induced by deposition into tissues or sclerosis or denaturation of crosslinked protein, similar diseases induced by aging and diabetic complications.

  本发明涉及一种生产 3-脱氧葡萄糖苷（3-DG）的抑制剂，它含有下式（I）所代表的至少一种对位苯甲酸衍生物或其药学上可接受的盐作为有效成分 其中 R 是氢或低级烷基；X 是氢、烷基、环烷基、低级烷基环烷基、苯基或苯基烷基，可任选被低级烷基、低级烷氧基、硝基和/或卤素取代；n 是 1 至 4 的整数。 本发明的化合物具有抑制 3-DG 生成的作用，3-DG 是一种高活性的中间体，参与 Maillard 反应中蛋白质交联的形成，因此，本发明的化合物可用于治疗和预防由组织沉积或硬化或交联蛋白质变性引起的各种疾病、由衰老和糖尿病并发症引起的类似疾病。
• [EN] NOVEL TREATMENT FOR NEUROLOGICAL AND PSYCHIATRIC DISORDERS<br/>[FR] NOUVEAU TRAITEMENT POUR AFFECTIONS NEUROLOGIQUES ET PSYCHIATRIQUES
  申请人：UNIV MARYLAND

  公开号：WO2002098421A1

  公开（公告）日：2002-12-12

  The presence of sorbitol in the cerebrospinal fluid of patients having psychiatric diseases and disorders or having neurological diseases or disorders is known. The use of compounds to prevent the accumulation of sorbitol in the central nervous system and brain for these patients are useful in the treatment of these diseases and disorders. Aldose reductase inhibitors are one type of compound useful in preventing the accumulation of sorbitol. Furthermore, one can administer aldose reductase inhibitors to prevent these diseases or disorders and to alleviate the symptoms of these diseases and disorders. The types of psychiatric diseases and disorders that can be treated or prevented include bipolar disorder, major depression, schizoaffective disorder, schizophrenia, dementia of elderly, affective psychoses, and episodic Axis II psychotic conditions. The types of neurological diseases and disorders that can be treated or prevented include multiple sclerosis, amyotrophic lateral sclerosis, and Alzheimer disease.

  患有精神疾病或紊乱或患有神经疾病或紊乱的患者的脑脊液中存在山梨醇的情况是已知的。使用化合物来防止这些患者的中枢神经系统和大脑中山梨醇的积累对于治疗这些疾病和紊乱是有用的。醛糖还原酶抑制剂是可用于防止山梨醇积累的一种化合物类型。此外，可以给患者服用醛糖还原酶抑制剂以预防这些疾病或紊乱，并缓解这些疾病或紊乱的症状。可以治疗或预防的精神疾病和紊乱类型包括双相障碍、重度抑郁症、精神分裂症、老年痴呆症、情感性精神病和偶发性II轴 psychotic conditions。可以治疗或预防的神经疾病和紊乱类型包括多发性硬化症、肌萎缩侧索硬化症和阿尔茨海默病。
• US4985453A
  申请人：——

  公开号：US4985453A

  公开（公告）日：1991-01-15
• US6040326A
  申请人：——

  公开号：US6040326A

  公开（公告）日：2000-03-21