2-imino-N,5,5-trimethyl-4-(2-phenylvinyl)-2,5-dihydrofuran-3-carboxamide | 1202751-59-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-imino-N,5,5-trimethyl-4-(2-phenylvinyl)-2,5-dihydrofuran-3-carboxamide
• 英文别名: 2-imino-N,5,5-trimethyl-4-(2-phenylethenyl)furan-3-carboxamide
• CAS: 1202751-59-4
• 化学式: C₁₆H₁₈N₂O₂
• 分子量: 270.331
• InChiKey: QILCWQSJTQGNMW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  20
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  62.2
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-imino-N,5,5-trimethyl-4-(2-phenylvinyl)-2,5-dihydrofuran-3-carboxamide 在 盐酸 作用下， 以 苯 为溶剂， 以97%的产率得到2-imino-N,5,5-trimethyl-4-(2-phenylvinyl)-2,5-dihydrofuran-3-carboxamide hydrochloride
  参考文献：
  名称：

  Synthesis of 2-imino-4-vinyl-2,5-dihydrofuran-3-carboxamides and some their chemical transformations

  摘要：

  2-Imino-2,5-dihydrofuran-3-carboxamides containing 2-phenyl- and 2-furylvinyl substituents in position 4 of the furan ring were synthesized by condensation of 2-imino-4-methyl-2,5-dihydrofuran-3-carboxamides with the corresponding aldehydes. Acid hydrolysis of 4-(2-arylvinyl)-2-imino-2,5-dihydrofuran-3-carboxamides gave 4-(2-arylvinyl)-2-oxo-2,5-dihydrofuran-3-carboxamides, and their condensation with malononitrile resulted in the formation of 2-dicyanomethylidene derivatives.

  DOI：

  10.1134/s1070428009070082
• 作为产物：
  描述：

  N,4,5,5-tetramethyl-2-oxo-2,5-dihydrofuran-3-carboxamide 、 苯甲醛 在 sodium hydroxide 作用下， 以 乙醇 为溶剂， 反应 4.0h， 以88%的产率得到2-imino-N,5,5-trimethyl-4-(2-phenylvinyl)-2,5-dihydrofuran-3-carboxamide
  参考文献：
  名称：

  Synthesis of 2-imino-4-vinyl-2,5-dihydrofuran-3-carboxamides and some their chemical transformations

  摘要：

  2-Imino-2,5-dihydrofuran-3-carboxamides containing 2-phenyl- and 2-furylvinyl substituents in position 4 of the furan ring were synthesized by condensation of 2-imino-4-methyl-2,5-dihydrofuran-3-carboxamides with the corresponding aldehydes. Acid hydrolysis of 4-(2-arylvinyl)-2-imino-2,5-dihydrofuran-3-carboxamides gave 4-(2-arylvinyl)-2-oxo-2,5-dihydrofuran-3-carboxamides, and their condensation with malononitrile resulted in the formation of 2-dicyanomethylidene derivatives.

  DOI：

  10.1134/s1070428009070082

文献信息

• Synthesis and Antibacterial Activity of N-Substituted 2-(Benzylimino)-4-styryl-2,5-dihydrofuran-3-carboxamides
  作者：L. V. Karapetyan、G. G. Tokmajyan、H. M. Stepanyan

  DOI：10.1134/s1070428021120113

  日期：2021.12