bicyclo<2.1.0>pentane radical | 84592-00-7

• 分子结构分类: 有机化合物 - 碳氢化合物 - 多环烃
• 英文名称: bicyclo<2.1.0>pentane radical
• CAS: 84592-00-7
• 化学式: C₅H₇
• 分子量: 67.1106
• InChiKey: ARXPAFRRAQLJLO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  5
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为反应物：
  描述：

  bicyclo<2.1.0>pentane radical 生成 cyclopent-3-enyl
  参考文献：
  名称：

  Bowry, Vincent W.; Lusztyk, Janusz; Ingold, Journal of the American Chemical Society, 1991, vol. 113, # 15, p. 5687 - 5698

  摘要：

  DOI：

文献信息

• A radical clock investigation of microsomal cytochrome P-450 hydroxylation of hydrocarbons. Rate of oxygen rebound
  作者：Vincent W. Bowry、K. U. Ingold

  DOI：10.1021/ja00015a025

  日期：1991.7

  A number of alkyl-substituted cyclopropanes for which the rates of ring opening of the corresponding cyclopropylcarbinyl radicals have been determined (see preceding paper in this issue) have been used as substrates for hydroxylation by phenobarbital-induced, rat liver microsomal cytochrome P-450 at 37-degrees-C. Three of these compounds gave both ring-closed and ring-opened alcohols, thus allowing the rate constant, k(OH), for ''oxygen rebound'' onto the corresponding carbon-centered radicals to be determined. In particular, both trans- (1bH) and cis- (1cH) 1,2-dimethylcyclopropane gave 4-penten-2-ol (2bOH) and 2-methyl-3-buten-1-ol (3bOH) together with the corresponding trans- (1bOH) or cis-(1cOH) 2-methylcyclopropanemethanols. Of much greater importance, for both 1bH and 1cH the ratios of the yields of the secondary-to-primary ring-opened alcohols, i.e., [2bOH]/[3bOH], were the same, within experimental error as the ratio of the rates of ring opening of the corresponding trans- (1b.) and cis- (1c.) methylcyclopropylmethyl radicals in solution at 37-degrees-C. This indicates that when lb. and lc. are formed from their parent hydrocarbons by H-atom abstraction in the hydrophobic pocket of cytochrome P-450 they are not detectably constrained in their subsequent reactions by their unusual environment. From the ratio of the yields of the unrearranged alcohol to each of the rearranged alcohols we calculate k(OH) values of 1.5 and 1.6 x 10(10) s-1 for lbH as substrate and values of 1.9 and 1.8 x 10(10) s-1 for 1cH as substrate. Consistent with these values we have obtained k(OH) = 2.2 x 10(10) s-1 for bicyclo[2.1.0]pentane as substrate. Substrates such as methylcyclopropane and 1,1-dimethylcyclopropane, for which the corresponding cyclopropylmethyl radicals undergo relatively slow ring opening, yielded only the ring-closed alcohols on oxidation with cytochrome P-450. 1,1,2,2-Tetramethylcyclopropane gave only a trace of a ring-opened alcohol, corresponding to k(OH) = 2.5 x 10(11) s-1 for this substrate. Hexamethylcyclopropane gave no detectable ring-opened alcohol from which observation a limit for k(OH) > 5 X 10(11) s-1 can bc calculated. Possible explanations for the unexpected behavior of these last two, relatively bulky, substrates are discussed.
• Bowry, Vincent W.; Lusztyk, Janusz; Ingold, Journal of the American Chemical Society, 1991, vol. 113, # 15, p. 5687 - 5698
  作者：Bowry, Vincent W.、Lusztyk, Janusz、Ingold

  DOI：——

  日期：——