1-(1H-Benzimidazol-2-ylmethyl)-2-morpholin-4-ylmethyl-1H-benzimidazole-5-carboxylic acid methyl ester | 475649-06-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-(1H-Benzimidazol-2-ylmethyl)-2-morpholin-4-ylmethyl-1H-benzimidazole-5-carboxylic acid methyl ester
• 英文别名: methyl 1-(1H-benzimidazol-2-ylmethyl)-2-(morpholin-4-ylmethyl)benzimidazole-5-carboxylate
• CAS: 475649-06-0
• 化学式: C₂₂H₂₃N₅O₃
• 分子量: 405.456
• InChiKey: LYKVMUAGJNZIJP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  30
• 可旋转键数：
  6
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  85.3
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• Benzimidazole compounds and antiviral uses thereof
  申请人：——

  公开号：US20030119754A1

  公开（公告）日：2003-06-26

  The present invention relates to novel benzimidazole compounds that have useful antiviral activity. More specifically, the invention encompasses benzimidazole compounds that inhibit membrane fusion associated events such as viral transmission, reduce viral load or otherwise treat viral infections. The invention also encompasses the use of benzimidazole compounds as inhibitors of membrane fusion associated events, such as viral transmission. In another embodiment, the invention encompasses processes for making benzimidazole compounds, methods of using the benzimidazole compounds and compositions comprising the benzimidazole compounds. Finally, the invention provides methods for treating, preventing or ameliorating symptoms associated with respiratory infection, particularly that caused by Respiratory Syncytial Virus utilizing the novel benzimidazole compounds of the invention.

  本发明涉及具有有用抗病毒活性的新型苯并咪唑化合物。更具体地说，该发明涵盖了抑制与膜融合相关事件（如病毒传播）、减少病毒载量或以其他方式治疗病毒感染的苯并咪唑化合物。该发明还包括将苯并咪唑化合物用作抑制与膜融合相关事件（如病毒传播）的抑制剂。在另一个实施例中，该发明涵盖了制备苯并咪唑化合物的方法、使用苯并咪唑化合物的方法以及包含苯并咪唑化合物的组合物。最后，该发明提供了利用本发明的新型苯并咪唑化合物治疗、预防或缓解与呼吸道感染相关症状，尤其是由呼吸道合胞病毒引起的方法。
• US7030150B2
  申请人：——

  公开号：US7030150B2

  公开（公告）日：2006-04-18
• [EN] BENZIMIDAZOLE COMPOUNDS AND ANTIVIRAL USES THEREOF<br/>[FR] COMPOSES DE BENZIMIDAZOLE ET UTILISATIONS ANTIVIRALES
  申请人：TRIMERIS INC

  公开号：WO2002092575A1

  公开（公告）日：2002-11-21

  The present invention relates to novel benzimidazole compounds that have useful antiviral activity. More specifically, the invention encompasses benzimidazole compounds that inhibit membrane fusion associated events such as viral transmission, reduce viral load or otherwise treat viral infections. The invention also encompasses the use of benzimidazole compounds as inhibitors of membrane fusion associated events, such as transmission. In another embodiment, the invention encompasses processes for making benzimidazole compounds, methods of using the benzimidazole compounds and compositions comprizing the benzimidazole compounds. Finally, the invention provides methods for treating, preventing or ameliorating symptoms associated with respiratory infection, particularly that caused by Respiratory Syncytial Virus utilizing the novel benzimidazole compounds of the invention.