4,4'-[3-(2-吡啶基)-1,2,4-三嗪-5,6-二基]二苯磺酸 | 32796-55-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 4,4'-[3-(2-吡啶基)-1,2,4-三嗪-5,6-二基]二苯磺酸
• 英文名称: Ferrozine free acid
• 英文别名: 4-[3-pyridin-2-yl-6-(4-sulfophenyl)-1,2,4-triazin-5-yl]benzenesulfonic acid
• CAS: 32796-55-7
• 化学式: C₂₀H₁₄N₄O₆S₂
• 分子量: 470.5
• InChiKey: JFVUMQYWYNDZDK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  32
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  177
• 氢给体数：
  2
• 氢受体数：
  10

文献信息

• [EN] TROPOLONE DERIVATIVES AND TAUTOMERS THEREOF FOR IRON REGULATION IN ANIMALS<br/>[FR] DÉRIVÉS DE TROPOLONE ET LEURS TAUTOMÈRES POUR LA RÉGULATION DU FER CHEZ LES ANIMAUX
  申请人：AMBYS MEDICINES INC

  公开号：WO2021076945A1

  公开（公告）日：2021-04-22

  Disclosed are a series of compounds or their tautomers having a general structure represented by Formula la or lb and pharmaceutically acceptable salts thereof. Also disclosed are pharmaceutical compositions comprising said compounds or tautomers or pharmaceutically acceptable salts thereof. Further disclosure relates to a method of treating a disease or condition associated with iron dysregulation or dysfunctional iron homeostasis, comprising administering to a subject in need thereof a therapeutically effective amount of Formula la or lb compounds or tautomers or pharmaceutically acceptable salts thereof.

  本文披露了一系列化合物或其互变异构体，其具有由化学式Ia或Ib表示的一般结构以及其药学上可接受的盐。还披露了包括所述化合物或互变异构体或其药学上可接受的盐的药物组合物。进一步的披露涉及一种治疗与铁调节失调或铁稳态功能异常相关的疾病或症状的方法，包括向需要的受试者施用化学式Ia或Ib化合物或互变异构体或其药学上可接受的盐的治疗有效量。
• Method of Inhibiting Ethylene Production in Plants
  申请人：Thrower Julie

  公开号：US20090011939A1

  公开（公告）日：2009-01-08

  Methods of inhibiting ethylene production in a plant are provided that involve contacting a plant or plant part with an inhibitor of 1-aminocyclopropane-1-carboxylic acid oxidase (ACCO). The methods can be used to delay fruit and vegetable ripening, flower opening, or senescence of cut flowers. Also described are kits including an ACCO inhibitor and a floral preservative.

  提供了抑制植物乙烯产生的方法，涉及将植物或植物部分与1-氨基环丙烷-1-羧酸氧化酶（ACCO）抑制剂接触。这些方法可用于延迟水果和蔬菜的成熟、花朵的开放，或者延缓切花的凋谢。还描述了包括ACCO抑制剂和花卉保鲜剂的试剂盒。
• [EN] HYDROXYBENZOIC ACID DERIVATIVES, METHODS AND USES THEREOF<br/>[FR] DÉRIVÉS D'ACIDE HYDROXYBENZOÏQUE, PROCÉDÉS ET UTILISATIONS ASSOCIÉS
  申请人：UNIV DO PORTO

  公开号：WO2018122789A1

  公开（公告）日：2018-07-05

  The present disclosure relates to the design and synthesis of new mitochondriotropic antioxidant compounds based on hydroxybenzoic acids and analogues. Furthermore, this disclosure is also related to the methods and uses of the hydroxybenzoic based derivatives and analogues, for example, in the field of human and animal diseases, for instance to treat mitochondrial dysfunction or mitochondrial deficiencies, and cosmetics, for instance to prevent or delay skin aging.

  本公开涉及基于羟基苯甲酸及其类似物的新型线粒体靶向抗氧化剂化合物的设计和合成。此外，本公开还涉及基于羟基苯甲酸衍生物和类似物的方法和用途，例如在人类和动物疾病领域中，例如用于治疗线粒体功能障碍或线粒体缺陷，以及在化妆品领域中，例如用于预防或延缓皮肤衰老。
• [EN] MOLECULAR SWITCHES BASED ON CIS/TRANS ISOMERIZATION OF BF2-COORDINATED AZO COMPOUNDS<br/>[FR] COMMUTATEURS MOLÉCULAIRES BASÉS SUR L'ISOMÉRISATION CIS/TRANS DE COMPOSÉS AZOÏQUES COORDONNÉS PAR BF2
  申请人：DARTMOUTH COLLEGE

  公开号：WO2015031518A1

  公开（公告）日：2015-03-05

  Provided herein are photochromic organic compounds of Formula I or Formula II, which are useful as molecular switches capable of being triggered via a cis/trans isomerization process. Methods of using the molecular switch compounds to form photopharmaceutical compounds that may be used to provide selective spatiotemporal activation of pharmaceutical agents are also disclosed.

  本文提供的是化学式I或化学式II的光致变色有机化合物，它们可作为分子开关使用，可通过顺反异构化过程触发。还公开了使用这些分子开关化合物形成光药物化合物的方法，这些化合物可用于提供药物代理的选择性时空激活。
• [EN] METHOD OF MODULATING RIBONUCLEOTIDE REDUCTASE<br/>[FR] MÉTHODE DE MODULATION DE RIBONUCLÉOTIDE RÉDUCTASE
  申请人：UNIV CASE WESTERN RESERVE

  公开号：WO2017100644A1

  公开（公告）日：2017-06-15

  A method of modulating ribonucleotide reductase activity in a neoplastic cell includes administering to the cell an amount of a ribonucleotide reductase modulator (RRmod), the amount being effective to inhibit neoplastic cell growth.

  一种调节肿瘤细胞核糖核苷酸还原酶活性的方法包括向细胞中投入一定量的核糖核苷酸还原酶调节剂（RRmod），该量足以抑制肿瘤细胞的生长。