Spiro[aziridin-1-ium-1,2'-isoindol-2-ium]-1',3'-dione;bromide | 1268728-28-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异吲哚及其衍生物
• 英文名称: Spiro[aziridin-1-ium-1,2'-isoindol-2-ium]-1',3'-dione;bromide
• CAS: 1268728-28-4
• 化学式: Br*C₁₀H₈NO₂
• 分子量: 254.083
• InChiKey: UJVDGSXWGKGNPL-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  -2.18
• 重原子数：
  14
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  34.1
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  N-(2-溴乙基)邻苯二甲酰亚胺 在 10H-吡啶并(3,2-b)(1,4)苯并噻嗪 、 potassium carbonate 作用下， 反应 0.13h， 以76%的产率得到Spiro[aziridin-1-ium-1,2'-isoindol-2-ium]-1',3'-dione;bromide
  参考文献：
  名称：

  Microwave-Assisted Synthesis of Azoniaspiro Compounds Using a Novel Catalyst, 1-Azaphenothiazine

  摘要：

  1-Azaphenothiazine catalyses the intramolecular cyclization of N-(bromoalkyl)-phthalimides in the presence of anhydrous K(2)CO(3) to form spiro cyclic quaternary ammonium salts, namely azoniaspiro compounds, under microwave irradiation. A novel and ecofriendly method was developed for the synthesis of azoniaspiro compounds, and the role of azaphenothiazine as a catalyst in such reactions has been established for the first time. In the future, this protocol can be extended to the synthesis of various substituted N-heterocycles by hydrolyzing the resulting azoniaspiro compounds.

  DOI：

  10.1080/00397910903576677