2-Propoxy-ethyl 2-[4-cyano-4-(3,4-dimethoxyphenyl)-5,N-dimethyl-hexylamino]-1-methylethyl 1,4-dihydro-2,6-dimethyl-4-(2,3-dichlorophenyl)-pyridine-3,5-dicarboxylate | 102336-19-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-Propoxy-ethyl 2-[4-cyano-4-(3,4-dimethoxyphenyl)-5,N-dimethyl-hexylamino]-1-methylethyl 1,4-dihydro-2,6-dimethyl-4-(2,3-dichlorophenyl)-pyridine-3,5-dicarboxylate
• 英文别名: 5-O-[1-[[4-cyano-4-(3,4-dimethoxyphenyl)-5-methylhexyl]-methylamino]propan-2-yl] 3-O-(2-propoxyethyl) 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate
• CAS: 102336-19-6
• 化学式: C₄₀H₅₃Cl₂N₃O₇
• 分子量: 758.783
• InChiKey: BMGTWIGOBACBOD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.2
• 重原子数：
  52
• 可旋转键数：
  21
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  119
• 氢给体数：
  1
• 氢受体数：
  10

文献信息

• Esters of 1,4-dihydro-2,6-dimethyl-3-(alkoxycarbonyl or alkoxyalkoxycarbonyl)-4-(substituted phenyl)-pyridine-5-carboxylic acid
  申请人：RECORDATI S.A. CHEMICAL and PHARMACEUTICAL COMPANY

  公开号：EP0164213A1

  公开（公告）日：1985-12-11

  Esters I (Ar=3-nitrophenyl or 2,3-dichlorophenyl, A=C2-C6 alkylene, R=C1-C6 alkyl optionally C1-C6 alkoxy monosubstituted, Ri =C1-C4 alkyl) have antihypertensive activity and are effective against coronary heart diseases, They are prepared starting from the aldehyde ArCHO and esters of acetoacetic acid and 3-aminocrotonic acid, Pharmaceutical preparations containing them are also described.

  酯类 I（Ar=3-硝基苯基或 2,3-二氯苯基，A=C2-C6 亚烷基，R=C1-C6 烷基，可选 C1-C6 烷氧基单取代，Ri=C1-C4 烷基）具有降压活性，对冠心病有效。
• US4634712A
  申请人：——

  公开号：US4634712A

  公开（公告）日：1987-01-06