Ac-Leu-Thr-Phe-D-Cys-His-Tyr-Trp-Ala-Gln-Leu-Cys-Ser-NH2 | 1334314-51-0

• 分子结构分类: 有机化合物 - 有机聚合物 - 多肽
• 英文名称: Ac-Leu-Thr-Phe-D-Cys-His-Tyr-Trp-Ala-Gln-Leu-Cys-Ser-NH2
• 英文别名: (2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-2-acetamido-4-methylpentanoyl]amino]-3-hydroxybutanoyl]amino]-3-phenylpropanoyl]amino]-3-sulfanylpropanoyl]amino]-3-(1H-imidazol-5-yl)propanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]propanoyl]amino]-N-[(2S)-1-[[(2R)-1-[[(2S)-1-amino-3-hydroxy-1-oxopropan-2-yl]amino]-1-oxo-3-sulfanylpropan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]pentanediamide
• CAS: 1334314-51-0
• 化学式: C₇₀H₉₇N₁₇O₁₇S₂
• 分子量: 1512.78
• InChiKey: KGCXZBMQFKRGKZ-UYWFRPSLSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.1
• 重原子数：
  106
• 可旋转键数：
  43
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  543
• 氢给体数：
  21
• 氢受体数：
  20

反应信息

• 作为反应物：
  描述：

  6,6’-bis(bromomethyl)-3,3’-bipyridine 、 Ac-Leu-Thr-Phe-D-Cys-His-Tyr-Trp-Ala-Gln-Leu-Cys-Ser-NH2 以 乙腈 为溶剂， 生成
  参考文献：
  名称：

  Conjugation of spermine enhances cellular uptake of the stapled peptide-based inhibitors of p53-Mdm2 interaction

  摘要：

  We report the first synthesis of the C-terminally spermine-conjugated stapled peptide-based inhibitors of the p53-Mdm2 interaction. Subsequent biological, biophysical and cellular uptake assays with the spermine-conjugated stapled peptides revealed that spermine conjugation minimally affects biological activity while significantly increases peptide helicity and cellular uptake without apparent cytotoxicity. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2011.10.009

文献信息

• Conjugation of spermine enhances cellular uptake of the stapled peptide-based inhibitors of p53-Mdm2 interaction
  作者：Avinash Muppidi、Xiaolong Li、Jiandong Chen、Qing Lin

  DOI：10.1016/j.bmcl.2011.10.009

  日期：2011.12

  We report the first synthesis of the C-terminally spermine-conjugated stapled peptide-based inhibitors of the p53-Mdm2 interaction. Subsequent biological, biophysical and cellular uptake assays with the spermine-conjugated stapled peptides revealed that spermine conjugation minimally affects biological activity while significantly increases peptide helicity and cellular uptake without apparent cytotoxicity. (C) 2011 Elsevier Ltd. All rights reserved.