2-Isopropylmercapto-imidazol | 7565-40-4

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫醚类
• 英文名称: 2-Isopropylmercapto-imidazol
• 英文别名: 2-isopropylsulfanyl-1H-imidazole；2-Isopropylmercapto-1H-imidazol；2-(propan-2-ylsulfanyl)-1H-imidazole；2-propan-2-ylsulfanyl-1H-imidazole
• CAS: 7565-40-4
• 化学式: C₆H₁₀N₂S
• mdl: MFCD19219017
• 分子量: 142.225
• InChiKey: HSQPCUWZLDLVHC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  9
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  54
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• TRIPEPTIDE COMPOUND, PREPARATION METHOD THEREFOR, AND APPLICATION THEREOF
  申请人：NORTHWEST UNIVERSITY

  公开号：US20170267718A1

  公开（公告）日：2017-09-21

  Provided are a tripeptide compound, a preparation method therefor, and an application thereof. The structure of the related compound is represented by formula (I). The provided compound has angiotensin converting enzyme inhibiting bioactivity, and the compound and a pharmaceutical composition thereof play a role in preventing and treating hypertension and other cardiocerebral vascular system diseases.

  提供了一种三肽化合物，其制备方法和应用。相关化合物的结构由式（I）表示。提供的化合物具有抑制血管紧张素转换酶的生物活性，该化合物及其药物组成对预防和治疗高血压和其他心脑血管系统疾病起着作用。
• ALBICIDIN DERIVATIVES, THEIR USE AND SYNTHESIS
  申请人：TECHNISCHE UNIVERSITÄT BERLIN

  公开号：US20150376120A1

  公开（公告）日：2015-12-31

  Antibiotically active compounds characterized by general formula (I), wherein X1, BB, BC, BD, BE and X2 are building blocks with D1, D2, D3, D4 or D5 being linkers which include carbon, sulphur, nitrogen, phosphor and/or oxygen atoms and which are covalently connecting the moities BA and BB, BB and BC, BC and BD, BD and BE and BE and BF, respectively, and wherein in particular the building block BC comprises an amino acid derivative. The compounds for use in a method of treatment of diseases, in particular for use in a method of treatment of bacterial infections are also disclosed.

  具有一般式（I）的抗生素活性化合物的特征，其中X1、BB、BC、BD、BE和X2是具有D1、D2、D3、D4或D5连接器的构建块，包括碳、硫、氮、磷和/或氧原子，并且共价连接BA和BB、BB和BC、BC和BD、BD和BE以及BE和BF的基团，其中特别是构建块BC包括一种氨基酸衍生物。该化合物用于治疗疾病的方法，特别是用于治疗细菌感染的方法。
• Tripeptide compound, preparation method therefor, and application thereof
  申请人：NORTHWEST UNIVERSITY

  公开号：US11358985B2

  公开（公告）日：2022-06-14

  Provided are a tripeptide compound, a preparation method therefor, and an application thereof. The structure of the related compound is represented by formula (I). The provided compound has angiotensin converting enzyme inhibiting bioactivity, and the compound and a pharmaceutical composition thereof play a role in preventing and treating hypertension and other cardiocerebral vascular system diseases.

  本文提供了一种三肽化合物、其制备方法及其应用。相关化合物的结构由式（I）表示。所提供的化合物具有抑制血管紧张素转换酶的生物活性，该化合物及其药物组合物在预防和治疗高血压及其他心脑血管系统疾病中发挥作用。
• US4175127A
  申请人：——

  公开号：US4175127A

  公开（公告）日：1979-11-20
• [EN] NOVEL QUINOXALINE DERIVATIVES<br/>[FR] NOUVEAUX DÉRIVÉS DE QUINOXALINE
  申请人：DONG A PHARM CO LTD

  公开号：WO2011122815A2

  公开（公告）日：2011-10-06

  This invention relates to a novel compound represented by the following Chemical Formula 1, a process for preparing it, and its pharmaceutically approved salt comprising it as an active ingredient. The compound of this invention is GLP 1 receptor regulating low molecular weight compound useful for treatment of metabolic diseases such as diabetes and obesity by regulating the function of glucagon like peptide 1 receptor (GLP 1 receptor) for the disease or disorder carried by GLP 1 since it has the effects on a drop of blood sugar and an improvement of insulin resistance.