N,N'-Dithiodimaleimid | 15395-94-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: N,N'-Dithiodimaleimid
• 英文别名: 1-[(2,5-Dioxoazolinyl)disulfanyl]azoline-2,5-dione；1-[(2,5-dioxopyrrol-1-yl)disulfanyl]pyrrole-2,5-dione
• CAS: 15395-94-5
• 化学式: C₈H₄N₂O₄S₂
• 分子量: 256.263
• InChiKey: SEBFKVKRAREXAK-UHFFFAOYSA-N

物化性质

• 熔点：
  213-215 °C(Solv: ethanol (64-17-5); tetrahydrofuran (109-99-9))
• 沸点：
  447.7±28.0 °C(Predicted)
• 密度：
  1.83±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.2
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  125
• 氢给体数：
  0
• 氢受体数：
  6

文献信息

• REVERSING THE UNDESIRABLE pH-PROFILE OF DOXORUBICIN VIA ACTIVATION OF A DISUBSTITUTED MALEAMIC ACID PRODRUG AT TUMOR ACIDITY
  申请人：The Research Foundation for The State University of new York

  公开号：US20210128592A1

  公开（公告）日：2021-05-06

  A pre-prodrug, comprising a drug, e.g., doxorubicin, which has off-target toxicity (e.g., cardiotoxicity) with respect to its antineoplastic activity, and an amine functionality of the drug incorporated into a disubstituted maleimide (DMI). The pre-prodrug may be linked to a targeting or de-targeting agent or a polar modulator, e.g., charged ligand, amino acid, peptide, etc., to increase therapeutic index. The pre-prodrug is hydrolyzed to the prodrug, having a disubstituted maleamic acid (DMA). A polar modulator such as glutamic acid prevents cellular uptake of the prodrug, but not the doxorubicin drug released from the prodrug after dissociation. The prodrug is pH sensitive, and below pH 7.0, tends to cleave to form free drug and cyclized maleic anhydride. Tumor environments tend to be more acidic, e.g., pH 6.8, than cardiac tissue, e.g., pH 7.4, and therefore the heart is spared while the drug is selectively released within a tumor.

  一种前前药，包括一种药物，例如阿霉素，其在抗肿瘤活性方面存在非靶向毒性（例如心脏毒性），以及药物的胺基功能并入二取代马来酰亚胺（DMI）中。前前药可以与靶向或去靶化剂或极性调节剂连接，例如带电配体、氨基酸、肽等，以增加治疗指数。前前药水解为前药，具有二取代马来酰胺（DMA）。极性调节剂如谷氨酸可防止前药的细胞摄取，但不影响前药解离后释放的阿霉素药物。前药对pH敏感，在pH 7.0以下，倾向于裂解形成游离药物和环化马来酸酐。肿瘤环境往往比心脏组织更酸性，例如pH 6.8，因此心脏得以保护，而药物选择性地在肿瘤内释放。
• POLYAMIC ACID RESIN SOLUTION CONTAINING INTERPENETRATING POLYMER AND LAMINATE USING THE SAME
  申请人：WANG Tsung-Hsiung

  公开号：US20130171459A1

  公开（公告）日：2013-07-04

  Provided is a polyamic acid resin solution containing interpenetrating polymer. The solution includes a polyamic acid resin dissolved in a solvent. The polyamic acid resin includes an interpenetrating polymer formed of polyamic acid twining around hyper-branched polybismaleimide. The hyper-branched polybismaleimide includes a bismaleimide polymer, a bismaleimide oligomer, a barbituric acid-bismaleimide copolymer or combinations thereof.

  提供的是一种含有相互渗透聚合物的聚酰亚胺树脂溶液。该溶液包括在溶剂中溶解的聚酰亚胺树脂。聚酰亚胺树脂包括由聚酰亚胺绕绕着超支化聚双马来酰亚胺形成的相互渗透聚合物。超支化聚双马来酰亚胺包括双马来酰亚胺聚合物、双马来酰亚胺寡聚物、巴比妥酸-双马来酰亚胺共聚物或其组合。
• Antibody targeting compounds
  申请人：THE SCRIPPS RESEARCH INSTITUTE

  公开号：EP2428226A1

  公开（公告）日：2012-03-14

  The present invention provides antibody targeting compounds in which the specificity of the antibody has been reprogrammed by covalently or noncovalently linking a targeting agent to the combining site of an antibody. By this approach, the covalently modified antibody takes on the binding specificity of the targeting agent. The compound may have biological activity provided by the targeting agent or by a separate biological agent. Various uses of the invention compounds are provided.

  本发明提供了抗体靶向化合物，通过共价或非共价方式将靶向制剂与抗体的结合位点连接，对抗体的特异性进行了重新编程。通过这种方法，共价修饰的抗体具有了靶向制剂的结合特异性。化合物的生物活性可由靶向药剂或单独的生物药剂提供。本发明化合物有多种用途。
• NON-AQUEOUS ELECTROLYTE SECONDARY BATTERY AND MATERIAL FOR USE IN SAME
  申请人：Mitsui Chemicals, Inc.

  公开号：EP3567663A1

  公开（公告）日：2019-11-13

  In a lithium ion secondary battery according to one embodiment of the present invention, an electrode includes an electrode active material, a conductive auxiliary agent, and a binding material configured by a binding component that binds the conductive auxiliary agent and forms a conduction path between the electrode active material, and by a melting point depressant that lowers a melting point of the binding component. The melting point depressant is a PTC functionality-imparting component that lowers the melting start temperature of the binding material and imparts the PTC functionality to the lithium ion secondary battery. The lithium ion secondary battery according to the invention is configured such that, when short circuit heat generation has occurred within the battery due to a conductive foreign substance, the binding material at a periphery of the foreign substance melts to sever the conduction path.

  在根据本发明一个实施例的锂离子二次电池中，电极包括电极活性材料、导电辅助剂和结合材料，结合材料由结合导电辅助剂并在电极活性材料之间形成传导路径的结合成分和降低结合成分熔点的熔点抑制剂配置而成。熔点抑制剂是一种 PTC 功能赋予成分，可降低结合材料的熔点起始温度，并将 PTC 功能赋予锂离子二次电池。根据本发明，锂离子二次电池的构造是，当导电异物在电池内产生短路热量时，异物外围的结合材料熔化，切断传导路径。
• Film composition and a film prepared thereby
  申请人：Industrial Technology Research Institute

  公开号：US11059938B2

  公开（公告）日：2021-07-13

  The disclosure provides a film composition, wherein the film composition includes an oligomer and a crosslinking agent. The oligomer can have a structure represented by Formula (I) wherein R1 and R2 are independently hydrogen, C1-20 alkyl group, C2-20 alkenyl group, C6-12 aryl group, C6-12 alkylaryl group, C5-12 cycloalkyl group, C6-20 cycloalkylalkyl group, alkoxycarbonyl group, or alkylcarbonyloxy group; R1 is not hydrogen when R2 is hydrogen; a is 0 or 1; 100≥n≥1; 100≥m≥1; and when n is not 0, the ratio of n to m is from 3:1 to 1:4. The weight ratio of the oligomer and the crosslinking agent can be from 9:1 to 3:7. The oligomer has a number average molecular weight (Mn) from 1,000 to 8,000.

  本公开提供了一种薄膜组合物，其中薄膜组合物包括低聚物和交联剂。低聚物可以具有由式（I）表示的结构 其中 R1 和 R2 独立地为氢、C1-20 烷基、C2-20 烯基、C6-12 芳基、C6-12 烷芳基、C5-12 环烷基、C6-20 环烷基、烷氧基羰基或烷基羰氧基；当 R2 为氢时，R1 不是氢；a 为 0 或 1；100≥n≥1；100≥m≥1；当 n 不是 0 时，n 与 m 之比为 3:1 至 1:4。低聚物和交联剂的重量比可以是 9:1 至 3:7。低聚物的平均分子量（Mn）为 1,000 至 8,000。