Ethanol, 2,2'-oxybis-, benzoate | 184488-47-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Ethanol, 2,2'-oxybis-, benzoate
• 英文别名: benzoic acid;2-(2-hydroxyethoxy)ethanol
• CAS: 184488-47-9
• 化学式: C11H16O5
• 分子量: 228.24
• InChiKey: MXPXQHNDBVPQEU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.37
• 重原子数：
  16
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  87
• 氢给体数：
  3
• 氢受体数：
  5

文献信息

• INTEGRATED PROCESS FOR THE PRODUCTION OF BENZOATE PLASTICIZERS
  申请人：Eastman Chemical Company

  公开号：US20160068655A1

  公开（公告）日：2016-03-10

  The invention relates to a process that integrates the oxidation of toluene to benzoic acid with the production of benzoate plasticizers. Toluene is fed to an oxidation vessel in the presence of oxygen and an oxidation catalyst wherein benzoic acid serves as the solvent for the oxidation. The crude benzoic acid produced is not purified and is then reacted with an alcohol in the presence of an esterification catalyst to produce the crude benzoate ester. The oxidation catalyst, esterification catalyst, and other impurities can be mostly removed from the crude benzoate ester in subsequent washing and filtering steps. The benzoate esters produced through this method can be made in fewer steps with both yields and purities above 80%.

  该发明涉及一种将甲苯氧化为苯甲酸并生产苯甲酸酯类可塑剂的过程。将甲苯与氧气和氧化催化剂一起加入氧化反应器中，其中苯甲酸作为氧化溶剂。产生的粗苯甲酸不进行纯化，然后在酯化催化剂的存在下与醇反应，生成粗苯甲酸酯。在随后的洗涤和过滤步骤中，可以从粗苯甲酸酯中去除大部分氧化催化剂、酯化催化剂和其他杂质。通过这种方法生产的苯甲酸酯可以在较少的步骤中制得，并且产率和纯度均可达到80%以上。
• [EN] METHOD FOR PREPARING BENZOIC ACID ESTERS<br/>[FR] PROCÉDÉ DE PRÉPARATION D'ESTERS D'ACIDE BENZOÏQUE
  申请人：SIBUR HOLDING PUBLIC JOINT STOCK CO

  公开号：WO2019059801A1

  公开（公告）日：2019-03-28

  The invention relates to the method of preparing benzoic acid esters which provides high selectivity of the process, and high yield of the desired product, as well as the reduction of the duration of the esterification process, comprising esterification of benzoic acid with monohydric alcohols having a number of carbon atoms from 6 to 12, or polyhydric alcohols having a number of carbon atoms from 2 to 10, in the presence of metal containing catalyst in the media of aromatic solvent at the stepwise buildup of the temperature of the process to 180-200°C, further to 200-220°C, and then to 240-250°C.

  本发明涉及制备苯甲酸酯的方法，该方法提供了高选择性的过程和高产率的所需产品，同时减少了酯化过程的持续时间，包括在芳香溶剂介质中，使用含金属催化剂，在温度逐步升高到180-200°C，进一步升高到200-220°C，然后升高到240-250°C的情况下，将苯甲酸与碳原子数为6-12的单元醇或碳原子数为2-10的多元醇酯化。
• Short duration depot formulations
  申请人：——

  公开号：US20040001889A1

  公开（公告）日：2004-01-01

  Methods and compositions for systemically or locally administering by implantation a beneficial agent to a subject are described, and include, for example, depot gel compositions that can be injected into a desired location and which can provide controlled release of a beneficial agent over a short duration of time. The compositions include a low molecular weight biocompatible polymer, a biocompatible solvent having low water miscibility that forms a viscous gel with the polymer and limits water uptake by the implant, and a beneficial agent.

  本文描述了系统性或局部通过植入给予有益药物的方法和组合物，其中包括例如可注射到所需位置的储库凝胶组合物，可以在短时间内提供有益药物的控制释放。该组合物包括低分子量生物相容性聚合物、生物相容性溶剂，具有低水溶性，与聚合物形成黏稠的凝胶，并限制植入物的吸水性，以及有益药物。
• Plasticizer for resin, and resin composition
  申请人：Takeda Shoji

  公开号：US20060148947A1

  公开（公告）日：2006-07-06

  The present invention provides a resin plasticizer comprising a compound represented by Formula (1): R 1 —(O—R 2 —CO) k —O[(CHR 3 ) p (CHR 4 ) q —O] r [(CHR 5 ) p′ (CHR 6 ) q′ —O] r′ —R 7 wherein R 1 is a hydrogen atom or a C 2-20 acyl group; R 2 is a hydroxycarboxylic acid residue; each R 3 , R 4 , R 5 and R 6 is independently a hydrogen atom or a methyl group; R 7 is a C 1-8 alkyl or C 2-20 acyl group; k is an integer from 1 to 60; each p, p′, q and q′ is an integer from 0 to 6, provided that 1≦p+q≦6 and 1≦p′+q′≦6; and each r and r′ is an integer from 0 to 7, provided that 1≦r+r′≦7; a resin composition comprising the plasticizer; and a molded article formed from the resin composition.

  本发明提供了一种树脂增塑剂，包括以下式子所表示的化合物：R1—(O—R2—CO)k—O[(CHR3)p(CHR4)q—O]r[(CHR5)p′(CHR6)q′—O]r′—R7，其中，R1是氢原子或C2-20酰基；R2是羟基羧酸残基；每个R3、R4、R5和R6分别是氢原子或甲基基团；R7是C1-8烷基或C2-20酰基；k是1到60的整数；每个p、p′、q和q′是0到6的整数，但要求1≦p+q≦6和1≦p′+q′≦6；每个r和r′是0到7的整数，但要求1≦r+r′≦7；以及包括该增塑剂的树脂组合物和由该树脂组合物形成的模塑制品。
• SHORT DURATION DEPOT FORMULATIONS
  申请人：Chen Guohua

  公开号：US20060165800A1

  公开（公告）日：2006-07-27

  Methods and compositions for systemically or locally administering by implantation a beneficial agent to a subject are described, and include, for example, depot gel compositions that can be injected into a desired location and which can provide controlled release of a beneficial agent over a short duration of time. The compositions include a low molecular weight biocompatible polymer, a biocompatible solvent having low water miscibility that forms a viscous gel with the polymer and limits water uptake by the implant, and a beneficial agent.

  本文描述了用于系统性或局部通过植入向受体施用有益剂的方法和组合物，其中包括例如可注入到所需位置的蓄积凝胶组合物，其可以在短时间内控制释放有益剂。该组合物包括低分子量生物相容性聚合物、生物相容性溶剂，具有低水亲和性，与聚合物形成粘稠凝胶，并限制了植入物的吸水，以及有益剂。