(2S)-3-[3-[2-(1,3-benzodioxol-5-yloxy)ethyl-methylamino]propyl]-2-(3,5-ditert-butyl-4-hydroxyphenyl)-1,3-thiazolidin-4-one;but-2-enedioic acid | 183181-89-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并间二氧杂环戊烯类
• 英文名称: (2S)-3-[3-[2-(1,3-benzodioxol-5-yloxy)ethyl-methylamino]propyl]-2-(3,5-ditert-butyl-4-hydroxyphenyl)-1,3-thiazolidin-4-one;but-2-enedioic acid
• CAS: 183181-89-7
• 化学式: C34H46N2O9S
• 分子量: 658.8
• InChiKey: ZNYNHEXNJWXNNA-JCOPYZAKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.4
• 重原子数：
  46
• 可旋转键数：
  13
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  171
• 氢给体数：
  3
• 氢受体数：
  11

文献信息

• CRYSTALLINE FUMARATE OF 2-PHENYL-1,3-THIAZOLIDINE-4-ON DERIVATIVE
  申请人：CHUGAI SEIYAKU KABUSHIKI KAISHA

  公开号：EP0974591A1

  公开（公告）日：2000-01-26

  Disclosed are crystals of a compound represented by the formula: and processes for preparing them.

  本发明公开了由式......表示的化合物的晶体及其制备方法： 及其制备工艺。
• TREATMENT OF NON-NEURONAL AND NON-MYOCARDIAL CELL, TISSUE AND ORGAN DAMAGE AND ASSOCIATED PAIN WITH PERSISTENT SODIUM CURRENT BLOCKERS
  申请人：Ozteo Pty Ltd

  公开号：EP2453893A1

  公开（公告）日：2012-05-23
• Treatment of non-neuronal and non-myocardial cell, tissue and organ damage and associated pain with persistent sodium current blockers
  申请人：Smith Paul Nathaniel

  公开号：US20120172363A1

  公开（公告）日：2012-07-05

  The present invention relates to a method for slowing the development of mammalian organ, tissue and cellular damage and death by using a persistent sodium current blocker (or a pharmaceutically acceptable salt or derivative thereof). The present invention further relates to a method for preventing damage and death in mammalian organs, tissues and cells or reducing the extent of damage and death in mammalian organs, tissues and cells. In particular the invention relates to a method for the treatment, amelioration or prevention of non-neuronal and non-myocardial cell or tissue damage or death and for reducing the pain associated with non-neuronal and non-myocardial cell or tissue damage.
• US6191281B1
  申请人：——

  公开号：US6191281B1

  公开（公告）日：2001-02-20
• US8906919B2
  申请人：——

  公开号：US8906919B2

  公开（公告）日：2014-12-09