3-(2-amino-5-iodo-benzoyl)-benzonitrile | 855167-96-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-(2-amino-5-iodo-benzoyl)-benzonitrile
• 英文别名: 3-(2-Amino-5-iodobenzoyl)benzonitrile
• CAS: 855167-96-3
• 化学式: C₁₄H₉IN₂O
• 分子量: 348.143
• InChiKey: BWYFWDWUKBYFSE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  66.9
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• Benzo[1,4]diazepin-2-one derivatives as phosphodiesterase PDE2 inhibitors, preparation and therapeutic use thereof
  申请人：NEURO3D

  公开号：EP1548011A1

  公开（公告）日：2005-06-29

  The invention relates to compounds having PDE2 inhibitory activities, as well as therapeutic methods by administering said compounds, in particular for treating various diseases of the central or peripheral nervous system. It further deals with pharmaceutical compositions comprising said compounds and methods for preparing said compounds. Compounds of general formula (I):

  该发明涉及具有PDE2抑制活性的化合物，以及通过给予该化合物进行治疗的方法，特别是用于治疗中枢或外周神经系统的各种疾病。还涉及包含该化合物的药物组合物以及制备该化合物的方法。通式(I)的化合物：
• Benzo-1,4-diazepin-2-one derivatives as phosphodiesterase pde2 inhibitors, preparation and therapeutic use thereof
  申请人：Abarghaz Mustapha

  公开号：US20070123519A1

  公开（公告）日：2007-05-31

  The invention relates to compounds having PDE2 inhibitory activities, as well as therapeutic methods by administering said compounds, in particular for treating various diseases of the central or peripheral nervous system. It further deals with pharmaceutical compositions comprising said compounds and methods for preparing said compounds.

  该发明涉及具有PDE2抑制活性的化合物，以及通过给予该化合物的治疗方法，特别是用于治疗中枢或外周神经系统的各种疾病。它还涉及包含该化合物的药物组合物和制备该化合物的方法。
• BENZO'1,4 ! DIAZEPIN-2-ONE DERIVATIVES AS PHOSPHODIESTERASE PDE2 INHIBITORS, PREPARATION AND THERAPEUTIC USE THEREOF
  申请人：NEURO3D

  公开号：EP1697332A1

  公开（公告）日：2006-09-06
• US7410963B2
  申请人：——

  公开号：US7410963B2

  公开（公告）日：2008-08-12
• [EN] BENZO`1,4 ! DIAZEPIN-2-ONE DERIVATIVES AS PHOSPHODIESTERASE PDE2 INHIBITORS, PREPARATION AND THERAPEUTIC USE THEREOF<br/>[FR] DERIVES DE BENZO`1,4 ! DIAZEPIN-2-ONE A TITRE D'INHIBITEURS DE PHOSPHODIESTERASE PDE2, LEUR PREPARATION ET LEUR APPLICATION THERAPEUTIQUE
  申请人：NEURO3D

  公开号：WO2005063723A1

  公开（公告）日：2005-07-14

  The invention relates to compounds of formula (I) having PDE2 inhibitory activities, as well as therapeutic methods by administering said compounds, in particular for treating various diseases of the central or peripheral nervous system. It further deals with pharmaceutical compositions comprising said compounds and methods for preparing said compounds. Compounds of general formula (I).