(4R,5S,6S)-6-[(1R)-1-hydroxyethyl]-4-methyl-3-methylsulfanyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid | 163580-66-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 内酰胺类
• 英文名称: (4R,5S,6S)-6-[(1R)-1-hydroxyethyl]-4-methyl-3-methylsulfanyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid
• CAS: 163580-66-3
• 化学式: C₁₁H₁₅NO₄S
• 分子量: 257.31
• InChiKey: DNBCJWHAPHHAMW-DBRKOABJSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.64
• 拓扑面积：
  103
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• Intermediates and process for preparing carbapenem derivatives
  申请人：FUJISAWA PHARMACEUTICAL CO., LTD.

  公开号：EP0499196A1

  公开（公告）日：1992-08-19

  New compounds of the formula in which R²is hydroxy(lower)alkyl or protected hydroxy(lower)alkyl, R³is hydrogen or lower alkyl, R⁶is an organic group, and Ris hydrogen, or certain groups, and processes for preparing them. The invention also relates to industrially excellent processes for preparing carbapenem derivatives having the formula in which R¹is carboxy or protected carboxy, R²is hydroxy(lower)alkyl or protected hydroxy(lower)alkyl, R³is hydrogen or lower alkyl, and R⁶is an organic group, or salts thereof, which are useful as antimicrobial agents.

  式的新化合物 其中 R² 是羟基（低级）烷基或受保护的羟基（低级）烷基、 R³ 是氢或低级烷基 R⁶ 是有机基团，和 是氢或某些基团、 以及制备它们的工艺。本发明还涉及制备具有以下式子的碳青霉烯衍生物的工业化优良工艺 其中 R¹为羧基或受保护的羧基、 R²为羟基（低级）烷基或受保护的羟基（低级）烷基、 R³ 是氢或低级烷基，以及 R⁶ 是有机基团、 或其盐类，可用作抗菌剂。
• Inhibitors of bacterial growth
  申请人：THE JOHNS HOPKINS UNIVERSITY

  公开号：US10695322B2

  公开（公告）日：2020-06-30

  New antimicrobials targeting L,D-transpeptidases, non-classical cysteine peptidases, have been developed and their unique chemical structures identified. Carbapenems and penems of the present invention are unique among β-lactams as they acylate and inhibit L,D-transpeptidases, which likely results in their superior antimicrobial potency. These new antimicrobial agents can be used alone, or in combination with other classic antimicrobial agents that target D,D transpeptidases, when treating bacterial infections.

  针对非典型半胱氨酸肽酶 L,D-反肽酶的新型抗菌剂已经开发出来，并确定了其独特的化学结构。本发明的碳青霉烯类和青霉烯类在β-内酰胺类药物中是独一无二的，因为它们能酰化并抑制 L,D-转肽酶，这可能是它们具有卓越抗菌效力的原因。在治疗细菌感染时，这些新型抗菌剂可单独使用，也可与其他针对 D,D-转肽酶的经典抗菌剂联合使用。
• NOVEL INHIBITORS OF BACTERIAL GROWTH
  申请人：THE JOHNS HOPKINS UNIVERSITY

  公开号：US20190167637A1

  公开（公告）日：2019-06-06

  New antimicrobials targeting L,D-transpeptidases, non-classical cysteine peptidases, have been developed and their unique chemical structures identified. Carbapenems and penems of the present invention are unique among β-lactams as they acylate and inhibit L,D-transpeptidases, which likely results in their superior antimicrobial potency. These new antimicrobial agents can be used alone, or in combination with other classic antimicrobial agents that target D,D transpeptidases, when treating bacterial infections.
• US5306816A
  申请人：——

  公开号：US5306816A

  公开（公告）日：1994-04-26