N-nitroso-N-phenyl-β-alanine ethyl ester | 99841-38-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-nitroso-N-phenyl-β-alanine ethyl ester
• 英文别名: N-nitroso-N-phenyl-β-alanine ethyl ester；β-Phenylnitrosamino-propionsaeure-aethylester；N-Nitroso-N-phenyl-β-alanin-aethylester
• CAS: 99841-38-0
• 化学式: C₁₁H₁₄N₂O₃
• 分子量: 222.244
• InChiKey: NDRHFYWXGPBYNU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.13
• 重原子数：
  16.0
• 可旋转键数：
  6.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  58.97
• 氢给体数：
  0.0
• 氢受体数：
  4.0

反应信息

• 作为反应物：
  描述：

  N-nitroso-N-phenyl-β-alanine ethyl ester 在 乙醚 、 aluminium amalgam 作用下， 生成 3-(N-phenyl-hydrazino)-propionic acid ethyl ester
  参考文献：
  名称：

  Interlocking Trajectories of Loss-Related Events and Depressive Symptoms Among Elders

  摘要：

  Objectives. As people age, their peers (who are also aging) become increasingly susceptible to health decline and death, implying potential growth in stressful loss-related events over time for the individual. Yet little research has examined trajectories of stress and their relationship to trajectories of depression among elders. The purpose of this research was to determine whether growth in loss-related events occurs for elders and whether stress growth is related to the well-known growth in depressive symptomatology in later life.Methods. Three waves of National Institute on Aging Established Populations for Epidemiologic Studies of the Elderly (Duke University site) data were used in the analyses. Latent growth curve models were estimated for stress. for depressive symptoms, and for stress predicting depression net of several covariates.Results. Findings include that (a) loss-events evidence clear growth across age at the aggregate level, but with Much variation within the sample, and (b) variation in growth in stress is strongly related to variation in growth in depressive symptoms.Discussion. The results suggest that stress in later life may be conceived of as a growth process, with strong consequences for trajectories of mental health.

  DOI：

  10.1093/geronb/57.2.s117
• 作为产物：
  描述：

  苯胺 在 盐酸 、 sodium nitrite 作用下， 生成 N-nitroso-N-phenyl-β-alanine ethyl ester
  参考文献：
  名称：

  Interlocking Trajectories of Loss-Related Events and Depressive Symptoms Among Elders

  摘要：

  Objectives. As people age, their peers (who are also aging) become increasingly susceptible to health decline and death, implying potential growth in stressful loss-related events over time for the individual. Yet little research has examined trajectories of stress and their relationship to trajectories of depression among elders. The purpose of this research was to determine whether growth in loss-related events occurs for elders and whether stress growth is related to the well-known growth in depressive symptomatology in later life.Methods. Three waves of National Institute on Aging Established Populations for Epidemiologic Studies of the Elderly (Duke University site) data were used in the analyses. Latent growth curve models were estimated for stress. for depressive symptoms, and for stress predicting depression net of several covariates.Results. Findings include that (a) loss-events evidence clear growth across age at the aggregate level, but with Much variation within the sample, and (b) variation in growth in stress is strongly related to variation in growth in depressive symptoms.Discussion. The results suggest that stress in later life may be conceived of as a growth process, with strong consequences for trajectories of mental health.

  DOI：

  10.1093/geronb/57.2.s117