4,4'-亚甲基二(苯甲脒) | 63690-09-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 4,4'-亚甲基二(苯甲脒)
• 英文名称: Benzenecarboximidamide, 4,4'-methylenebis-
• 英文别名: 4-[(4-carbamimidoylphenyl)methyl]benzenecarboximidamide
• CAS: 63690-09-5
• 化学式: C₁₅H₁₆N₄
• 分子量: 252.31
• InChiKey: FTMSARBDCMBEPC-UHFFFAOYSA-N

物化性质

• 沸点：
  385.5°C (rough estimate)
• 密度：
  1.1526 (rough estimate)

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  19
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  99.7
• 氢给体数：
  4
• 氢受体数：
  2

文献信息

• MACROCYCLIC INHIBITORS OF SERINE PROTEASE ENZYMES
  申请人：Marsault Éric

  公开号：US20120270807A1

  公开（公告）日：2012-10-25

  The present invention relates to novel macrocyclic compounds and salts thereof that bind to and/or are inhibitors of serine protease enzymes. The present invention also relates to intermediates of these compounds, pharmaceutical compositions containing these compounds and methods of using the compounds. These compounds are useful as therapeutics for treatment and prevention of a range of disease indications including hyperproliferative disorders, in particular those characterized by tumor metastasis, inflammatory disorders, skin and tissue disorders, cardiovascular disorders, respiratory disorders and viral infections.

  本发明涉及新型大环化合物及其盐，它们能结合和/或抑制丝氨酸蛋白酶酶。本发明还涉及这些化合物的中间体，含有这些化合物的制药组合物以及使用这些化合物的方法。这些化合物可用于治疗和预防一系列疾病指标，包括增生性疾病，特别是那些以肿瘤转移为特征的疾病，炎症性疾病，皮肤和组织疾病，心血管疾病，呼吸系统疾病和病毒感染。
• METHODS OF USING MACROCYCLIC INHIBITORS OF SERINE PROTEASE ENZYMES
  申请人：Marsault Éric

  公开号：US20120270769A1

  公开（公告）日：2012-10-25

  The present invention relates to novel macrocyclic compounds and salts thereof that bind to and/or are inhibitors of serine protease enzymes and methods of using the compounds. The present invention also relates to intermediates of these compounds, pharmaceutical compositions containing these compounds and methods of using the same. These compounds are useful as therapeutics for treatment and prevention of a range of disease indications including hyperproliferative disorders, in particular those characterized by tumor metastasis, inflammatory disorders, skin and tissue disorders, cardiovascular disorders, respiratory disorders and viral infections.

  本发明涉及新型大环化合物及其盐，这些化合物与/或抑制丝氨酸蛋白酶酶的结合，并使用这些化合物的方法。本发明还涉及这些化合物的中间体、含有这些化合物的制药组合物以及使用它们的方法。这些化合物可用作治疗和预防一系列疾病指标的治疗剂，包括高增殖性疾病，特别是肿瘤转移、炎症性疾病、皮肤和组织疾病、心血管疾病、呼吸系统疾病和病毒感染。
• Device for the removal of toxic substances from blood
  申请人：Nederlandse Organisatie voor Toegepast-Natuurwetenschappelijk Onderzoek TNO

  公开号：EP1935441A1

  公开（公告）日：2008-06-25

  The present invention relates to a device for the removal of toxic substances from dialysate fluids and/or from blood from a patient comprising a sorption-filter device (2) for removing toxins, small and middle-sized molecules from dialysate fluids and/or patient blood plasma, said sorption filter comprising as a sorbing material a smectite, nanoclay, a layered double hydroxide, a modified biopolymer or a combination thereof.

  本发明涉及一种从透析液和/或患者血液中去除有毒物质的装置，该装置包括一个用于从透析液和/或患者血浆中去除毒素、中小分子的吸附过滤装置（2），所述吸附过滤装置的吸附材料包括埃米土、纳米粘土、层状双氢氧化物、改性生物聚合物或它们的组合。
• Sorbent material
  申请人：Nederlandse Organisatie voor Toegepast- Natuurwetenschappelijk Onderzoek TNO

  公开号：EP2072117A1

  公开（公告）日：2009-06-24

  The present invention relates to a sorbent material for removing substances from an aqueous liquid comprising a nanostructured sorption material captured in a porous polymer matrix, wherein the pores in said matrix are of a size that allows the entry into said matrix of substances sought to be removed from said liquid while preventing the escape of said nanostructured sorption material or preventing the entry into said matrix of substances not sought to be removed from said liquid.

  本发明涉及一种用于从水性液体中去除物质的吸附剂材料，该材料包括俘获在多孔聚合物基质中的纳米结构吸附材料，其中所述基质中的孔隙大小允许想要从所述液体中去除的物质进入所述基质，同时防止所述纳米结构吸附材料逸出或防止不想要从所述液体中去除的物质进入所述基质。
• Electrosorption device for the purification of blood and other fluids
  申请人：ICinnovation BV

  公开号：EP2087916A1

  公开（公告）日：2009-08-12

  The present invention relates to a device for the removal of substances from blood and other fluids, said device comprising i) an electrosorption filter for removing substances such as toxins, toxic solutes, toxic small and middle-sized molecules and protein bound toxins from blood, blood plasma or dialysate fluid, said electrosorption filter comprising a DC power source, a set of electrodes, nanostructured sorption material and/or a porous polymer matrix, ii) an inlet for entry of blood or blood plasma or dialysate fluid into said device, iii) an outlet for the removal of purified blood or blood plasma or dialysate fluid from said device, and iv) a conduit connecting said inlet with said outlet and holding said electrosorption filter such that said blood, blood plasma or dialysate fluid is forced through said electrosorption filter. The device of the present invention is also applicable for the purification of other fluids such as water, chemicals and other biofluids.

  本发明涉及一种用于从血液和其他液体中去除物质的装置，所述装置包括 i) 用于从血液、血浆或透析液中去除毒素、有毒溶质、有毒中小分子和蛋白质结合毒素等物质的电吸附过滤器，所述电吸附过滤器包括直流电源、一组电极、纳米结构吸附材料和/或多孔聚合物基质，ii) 用于将血液或血浆或透析液输入所述装置的入口，iii) 用于去除净化血液或血浆或透析液的出口、电吸附过滤器包括直流电源、一组电极、纳米结构吸附材料和/或多孔聚合物基质；ii) 入口，用于将血液或血浆或透析液输入所述装置；iii) 出口，用于将净化后的血液或血浆或透析液从所述装置中排出；以及 iv) 导管，连接所述入口和所述出口，并容纳所述电吸附过滤器，使所述血液、血浆或透析液被迫通过所述电吸附过滤器。本发明的装置也适用于其他流体的净化，如水、化学品和其他生物流体。