| 1130850-93-9

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• CAS: 1130850-93-9
• 化学式: C₄₀H₅₂O₄
• 分子量: 596.85
• InChiKey: MYMCZCKTNLHNCA-KKQUBEGKSA-N

反应信息

• 作为反应物：
  描述：

  在 10% Pd/C 、 氢气 作用下， 以 乙醇 、 乙酸乙酯 为溶剂， 反应 16.0h， 生成
  参考文献：
  名称：

  Estradiol dimers as a new class of steroid sulfatase reversible inhibitors

  摘要：

  A series of estradiol dimers was synthesized or selected from compounds available in our laboratory and tested for inhibition against steroid sulfatase. Dimers linked by their C17 position, compounds 7 and 8, showed inhibitory potency similar (56% and 54% at 1 mu M) to that of our best previously reported reversible inhibitor EM-690 (62% at 1 mu M). Docking experiment seems to indicate that C17-C17 dimers bind in a similar way to EM-690 whereas C16-O3 and C16-C16 dimers bind in an upside-down position. (c) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2008.12.047
• 作为产物：
  描述：

  在 四丁基氟化铵 作用下， 以 四氢呋喃 为溶剂， 反应 1.0h， 生成
  参考文献：
  名称：

  Estradiol dimers as a new class of steroid sulfatase reversible inhibitors

  摘要：

  A series of estradiol dimers was synthesized or selected from compounds available in our laboratory and tested for inhibition against steroid sulfatase. Dimers linked by their C17 position, compounds 7 and 8, showed inhibitory potency similar (56% and 54% at 1 mu M) to that of our best previously reported reversible inhibitor EM-690 (62% at 1 mu M). Docking experiment seems to indicate that C17-C17 dimers bind in a similar way to EM-690 whereas C16-O3 and C16-C16 dimers bind in an upside-down position. (c) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2008.12.047