4-(4-Acetaminobenzyl) pyridin | 32341-84-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-(4-Acetaminobenzyl) pyridin
• 英文别名: N-(4-pyridin-4-ylmethyl-phenyl)-acetamide；N-[4-(pyridin-4-ylmethyl)phenyl]acetamide
• CAS: 32341-84-7
• 化学式: C₁₄H₁₄N₂O
• mdl: MFCD00441120
• 分子量: 226.278
• InChiKey: PJZVXHILLZKMEX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  42
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• 5-(Pyridinyl)-benzimidazole derivatives and preparation
  申请人：STERLING DRUG INC.

  公开号：EP0055453A2

  公开（公告）日：1982-07-07

  5-(Py-Y)-1H-benzimidazol-2-ol or 5-(Py-Y-1H-benzimidazole-2-thiol or lower-alkyl ethers or thioethers thereof or pharmaceutically-acceptable acid-addition salts thereof where Y is a direct linkage or lower-alkylene having one or two carbon atoms and Py is 4- or 3-pyridinyl, optionally having one or two lower-alkyl substituents, or 1-oxide of such pyridinyl, useful as cardiotonics, are prepared by reacting 4-(Py-Y)-1,2-benzenediamine with urea or carbony-Idiimidazole to produce 5-(Py-Y)-1H-benzimidazol-2-ol or with thiourea, an alkali metal lower-alkyl xanthate orthiocar- bonyldiimidazole to produce 5-(Py-Y)-1H-benzimidazole-2-thiol and by reacting 5-(Py-Y)-lH-benzimidazole-2-thiol with a lower-alkylating agent to produce 2-(lower-alkylthio-)-5-(Py-Y)-1 H-benzimidazole. 2-(Lower-alkoxy)-5-(Py-Y)-1 H-benzimidazoles are prepared by reacting 4-(Py-Y)1,2-benzenediamine with tetra-(lower-alkoxy)methane. The N-oxides may be prepared by reaction with a per-organic acid in a suitable solvent.

  5-(Py-Y)-1H-苯并咪唑-2-醇或 5-(Py-Y)-1H-苯并咪唑-2-硫醇或其低级烷基醚或硫醚或其药学上可接受的酸加成盐，其中 Y 为直接连接或具有一个或两个碳原子的低级亚烷基，Py 为 4-或 3-吡啶基，可选具有一个或两个低级烷基取代基，或此类吡啶基的 1-氧化物，可用作强心剂、4-(Py-Y)-1,2-苯二胺与脲或碳二咪唑反应生成 5-(Py-Y)-1H-苯并咪唑-2-醇，或与硫脲反应生成 5-(Py-Y)-1H-苯并咪唑-2-醇、碱金属低级烷基黄原酸盐原碳二咪唑，生成 5-(Py-Y)-1H-苯并咪唑-2-硫醇，并将 5-(Py-Y)-lH-苯并咪唑-2-硫醇与低级烷基化剂反应，生成 2-(低级烷基硫代)-5-(Py-Y)-1H-苯并咪唑。2-(低级烷氧基)-5-(Py-Y)-1 H-苯并咪唑是通过 4-(Py-Y)1,2-苯二胺与四(低级烷氧基)甲烷反应制备的。N-氧化物可通过在合适的溶剂中与过有机酸反应制备。
• Pyridinyl-substituted-benz imidazole derivatives and preparation
  申请人：STERLING DRUG INC.

  公开号：EP0056260A1

  公开（公告）日：1982-07-21

  2-R-5-(Py-Y)-lH-benzimidazole or pharmaceutically-acceptable acid-addition salt thereof, useful as a cardiotonic, is prepared by reacting 4-(Py-Y)-1,2-benzenediamine with a tri-(lower-alkyl)ortho-(lower-alkanoate) of the formula R-C(ORI)3, where R is hydrogen or lower-alkyl, Y is a direct linkage or lower-alkylene having one or two carbon atoms, and Py is 4- or 3-pyridinyl or 4- or 3-pyridinyl having one or two lower-alkyl substituents, or with dimethylformamide dimethyl acetal or dimethylacetamide dimethyl acetal to produce said 2-R-5-(Py-Y)-1H-benzimidazole where R is methyl or ethyl respectively. The same compound where R is lower-alkyl is prepared in two steps by first reacting 4-(Py-Y)-1,2-benzenediamine with an alkanoylating agent providing alkanoyl of the formula R'-C=O to produce N2[R'C(=O)]-4-(Py-Y)-1,2-benzenediamine and heating the latter compound to produce said 2-R'-5-(Py-Y)-1H-benzimidazole, where R' is lower-alkyl. Also shown is 1-hydroxy-2-R-6-(Py-Y)-1H-benzimidazole or pharmaceutically-acceptable acid-addition salt thereof, useful as a cardiotonic and prepared by reacting 3-nitro-N-(RCO)-4-(Py-Y)-benzeneamine with hydrogen under catalytic hydrogen conditions.

  可用作强心剂的 2-R-5-(Py-Y)-lH-苯并咪唑或其药学上可接受的酸加成盐，是通过 4-(Py-Y)-1,2-苯二胺与式 R-C(ORI)3（其中 R 为氢或低级烷基）的三(低级烷基)原(低级烷酸)酯反应制备的、Y 是具有一个或两个碳原子的直链烷基或低级烷基，Py 是 4-或 3-吡啶基或具有一个或两个低级烷基取代基的 4-或 3-吡啶基，或与二甲基甲酰胺二甲基缩醛或二甲基乙酰胺二甲基缩醛生成所述 2-R-5-(Py-Y)-1H-苯并咪唑，其中 R 分别为甲基或乙基。R 为低级烷基的相同化合物分两步制备，首先将 4-(Py-Y)-1,2-苯二胺与提供式 R'-C=O 烷酰基的烷酰化剂反应，生成 N2[R'C(=O)]-4-(Py-Y)-1,2-苯二胺，然后加热后一种化合物，生成所述 2-R'-5-(Py-Y)-1H-苯并咪唑，其中 R' 为低级烷基。图中还显示了 1-羟基-2-R-6-(Py-Y)-1H-苯并咪唑或其药学上可接受的酸加成盐，可用作强心剂，其制备方法是在催化氢条件下使 3-硝基-N-(RCO)-4-(Py-Y)-苯胺与氢反应。
• Compounds for increasing lipid synthesis and storage
  申请人：NUtech Ventures

  公开号：US10351883B2

  公开（公告）日：2019-07-16

  This invention relates to methods for increasing lipid accumulation and lipid production in cells. Methods of producing biofuel from cells and preparing nutraceuticals comprising lipids produced according to a method provided herein are also provided.

  本发明涉及增加细胞中脂质积累和脂质生产的方法。本发明还提供了从细胞中生产生物燃料的方法，以及制备包含根据本发明提供的方法生产的脂质的营养保健品的方法。
• Compounds for Increasing Lipid Synthesis and Storage
  申请人：NUtech Ventures

  公开号：US20160312253A1

  公开（公告）日：2016-10-27

  This invention relates to methods for increasing lipid accumulation and lipid production in cells. Methods of producing biofuel from cells and preparing nutraceuticals comprising lipids produced according to a method provided herein are also provided.
• US4331671A
  申请人：——

  公开号：US4331671A

  公开（公告）日：1982-05-25