1-cyano-2,3-di(2-ethoxyethyl)guanidine | 210289-74-0

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 1-cyano-2,3-di(2-ethoxyethyl)guanidine
• 英文别名: 1-cyano-2,3-bis(2-ethoxyethyl)guanidine
• CAS: 210289-74-0
• 化学式: C₁₀H₂₀N₄O₂
• 分子量: 228.294
• InChiKey: TXJAKWFEQCCJQD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.08
• 重原子数：
  16.0
• 可旋转键数：
  8.0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  78.67
• 氢给体数：
  2.0
• 氢受体数：
  4.0

反应信息

• 作为反应物：
  描述：

  1-cyano-2,3-di(2-ethoxyethyl)guanidine 在 盐酸 、 硫代乙酰胺 作用下， 反应 3.0h， 以87%的产率得到[Bis-(2-ethoxy-ethylamino)-methylene]-thiourea
  参考文献：
  名称：

  Anti- Helicobacter pylori agents. 2. Structure activity relationships in a new series of 2-alkylguanidino-4-furylthiazoles

  摘要：

  SAR for antimicrobial activity against H. pylori was investigated in a new series of 2-alkylguanidino-4-furylthiazoles. Of the compounds obtained, cyclohexylmethyl and ethoxyethyl derivatives were identified as a novel class of anti-H. pylori agents which possessed potent and selective antimicrobial activity against H. pylori. These compounds also showed gastric antisecretory activity. (C) 1998 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(98)00206-6
• 作为产物：
  描述：

  2-乙氧基乙胺 、 N-氰亚胺基-S,S-二硫代碳酸二甲酯 以 N,N-二甲基甲酰胺 为溶剂， 反应 7.0h， 以60%的产率得到1-cyano-2,3-di(2-ethoxyethyl)guanidine
  参考文献：
  名称：

  Anti- Helicobacter pylori agents. 2. Structure activity relationships in a new series of 2-alkylguanidino-4-furylthiazoles

  摘要：

  SAR for antimicrobial activity against H. pylori was investigated in a new series of 2-alkylguanidino-4-furylthiazoles. Of the compounds obtained, cyclohexylmethyl and ethoxyethyl derivatives were identified as a novel class of anti-H. pylori agents which possessed potent and selective antimicrobial activity against H. pylori. These compounds also showed gastric antisecretory activity. (C) 1998 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(98)00206-6