N,N'-(1,4-phenylene)bis(4-(chloromethyl)benzamide) | 1070880-16-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N,N'-(1,4-phenylene)bis(4-(chloromethyl)benzamide)
• 英文别名: Benzamide, N,N'-1,4-phenylenebis[4-(chloromethyl)-；4-(chloromethyl)-N-[4-[[4-(chloromethyl)benzoyl]amino]phenyl]benzamide
• CAS: 1070880-16-8
• 化学式: C₂₂H₁₈Cl₂N₂O₂
• 分子量: 413.303
• InChiKey: SBUVHKHRCAKDLK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  28
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  58.2
• 氢给体数：
  2
• 氢受体数：
  2

文献信息

• Biodegradable polyionenes
  申请人：AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH

  公开号：US11198761B2

  公开（公告）日：2021-12-14

  Synthesis of polyionenes with built-in degradable linkers through addition polymerization of a novel class of degradable A2-type monomers (d-A2), and their use as antimicrobial agents are disclosed. A library of biodegradable polyionenes and Gemini-surfactants made from d-A2 monomers are also disclosed. These materials have potent and broad spectrum of antimicrobial activity with high selectivity over mammalian cells.

  本研究公开了通过对一类新型可降解 A2 型单体（d-A2）进行加成聚合，合成具有内置可降解连接体的聚阴离子，并将其用作抗菌剂。此外，还公开了一个由 d-A2 单体制成的可生物降解的聚阴离子和双子表面活性剂库。这些材料具有强效、广谱的抗菌活性，对哺乳动物细胞具有高选择性。
• BIODEGRADABLE POLYIONENES
  申请人：AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH

  公开号：US20200040136A1

  公开（公告）日：2020-02-06

  Synthesis of polyionenes with built-in degradable linkers through addition polymerization of a novel class of degradable A 2 -type monomers (d-A 2 ), and their use as antimicrobial agents are disclosed. A library of biodegradable polyionenes and Gemini-surfactants made from d-A 2 monomers are also disclosed. These materials have potent and broad spectrum of antimicrobial activity with high selectivity over mammalian cells.