1-[(Methanesulfonyl)oxy]pyridin-1-ium | 137838-33-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 1-[(Methanesulfonyl)oxy]pyridin-1-ium
• 英文别名: pyridin-1-ium-1-yl methanesulfonate
• CAS: 137838-33-6
• 化学式: C6H8NO3S+
• 分子量: 174.2
• InChiKey: PTQSJRNGWJFVPC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  55.6
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• PROCESS FOR PRODUCTION OF BIS-QUATERNARY AMMONIUM SALT, AND NOVEL INTERMEDIATE
  申请人：Okamoto Kuniaki

  公开号：US20120130107A1

  公开（公告）日：2012-05-24

  Object To provide a method for producing a bis-quaternary ammonium salt efficiently and a novel synthetic intermediate thereof. Solution The present invention relates to a method for producing a bis-quaternary ammonium salt represented by a general formula [3] which comprises reacting a disulfonic acid ester represented by a general formula [1] (in the formula, definitions of two R 1 's and T are as described in claim 1 ) with a tertiary amine represented by a general formula [2] (in the formula, definitions of R 3 to R 5 are as described in claim 1 ), and a disulfonic acid ester represented by a general formula [1′] (in the formula, two R 16 's represent independently a halogen atom or a C1-C3 fluoroalkyl group, and two m's represent independently an integer of 1 to 5).

  提供一种高效生产双季铵盐和其新型合成中间体的方法。本发明涉及一种生产由通用式[3]表示的双季铵盐的方法，包括将由通用式[1]表示的二磺酸酯（在该式中，两个R1和T的定义如权利要求1中所述）与由通用式[2]表示的三级胺（在该式中，R3到R5的定义如权利要求1中所述）以及由通用式[1']表示的二磺酸酯（在该式中，两个R16独立表示卤原子或C1-C3氟烷基，两个m独立表示1至5的整数）反应。
• [EN] PROCESS FOR THE PREPARATION OF BIMATOPROST<br/>[FR] PROCÉDÉ DE PRÉPARATION DE BIMATOPROST
  申请人：GENTEC S A

  公开号：WO2017182465A1

  公开（公告）日：2017-10-26

  It is provided a process for the preparation of bimatoprost, which comprises: a) reacting a compound of formula (III) with ethylamine in the presence of a suitable solvent; and b) deprotecting compound obtained in step a) to obtain bimatoprost, wherein R1 is selected from (C1-C16)alkyl, (C1C16)haloalkyl, (C2-C16)alkenyl, (C2-C16)haloalkenyl, (C1-C16)alkoxy(C1-C16)alkyl, aryl, (C1-C16)alkylaryl, allyl, - (CH2-CH2-O)n-CH3 wherein n = 1, 2, 3 or 4, and -CH(O-CH2-CH2)2; R2 is selected from H, (C1-C16)alkyl, (C1-C16)haloalkyl, (C2-C16)alkenyl, (C2- C16)haloalkenyl, (C1-C16)alkoxy(CrC16)alkyl, aryl, (C1-C16)alkylaryl, allyl; or, alternatively, R1 and R2 taken together are selected from -CH2-CH2-CH2-, -CH2-CH2-, -O-CH2-CH2-, and -O-CH=CH-. There are also provided intermediates useful in such preparation process.

  提供了一种制备比马前列素的方法，包括：a）在适当的溶剂存在下，将化合物（III）与乙胺发生反应；b）去保护步骤a）中得到的化合物，以获得比马前列素，其中R1选自（C1-C16）烷基，（C1-C16）卤代烷基，（C2-C16）烯基，（C2-C16）卤代烯基，（C1-C16）烷氧基（C1-C16）烷基，芳基，（C1-C16）烷基芳基，烯丙基，-（CH2- -O）n-CH3其中n = 1, 2, 3或4，和-CH（O- - ）2；R2选自H，（C1-C16）烷基，（C1-C16）卤代烷基，（C2-C16）烯基，（C2-C16）卤代烯基，（C1-C16）烷氧基（C1-C16）烷基，芳基，（C1-C16）烷基芳基，烯丙基；或者，R1和R2一起选自- - - -，- - -，-O- - -，和-O-CH=CH-。还提供了在这种制备过程中有用的中间体。
• BICYCLIC COMPOUND
  申请人：TAKEDA PHARMACEUTICAL COMPANY LIMITED

  公开号：US20140243310A1

  公开（公告）日：2014-08-28

  The present invention provides a compound represented by the formula (I): wherein each symbol is as defined in the specification, or a salt thereof.

  本发明提供了一种由以下公式（I）表示的化合物：其中每个符号如规范中定义的，或其盐。
• [EN] A PURIFICATION METHOD OF IONIC LIQUIDS TO OBTAIN THEIR HIGH PURITY<br/>[FR] PROCEDE DE PURIFICATION DE LIQUIDES IONIQUES PERMETTANT D'OBTENIR UNE GRANDE PURETE
  申请人：CHEMTECH RES INC

  公开号：WO2004080974A1

  公开（公告）日：2004-09-23

  Disclosed is an ionic liquid purification method for preparing high purity ionic liquids which can be used as solvents for organic, inorganic and biochemical reactions or as electrolytic solutions of storage batteries, secondary batteries, or fuel batteries, by removing organic halide salts, organic salts, halide residues, acid residues, excess alkali metals and so on, from unpurified ionic liquids using liquid/liquid continuous extraction.

  公开了一种离子液体纯化方法，用于制备高纯度的离子液体，这些离子液体可以用作有机、无机和生物化学反应的溶剂，或用作储能电池、二次电池或燃料电池的电解质溶液，通过使用液液连续萃取从未纯化的离子液体中去除有机卤化物盐、有机盐、卤化物残留物、酸残留物、过量碱金属等。
• IONIC LIQUID CONTAINING ALLYLSULFONATE ANION
  申请人：Watahiki Tsutomu

  公开号：US20120157680A1

  公开（公告）日：2012-06-21

  PROBLEM: Providing a novel ionic liquid, which is low-cost, environment-friendly, and has low viscosity and melting point. MEANS FOR SOLVING THE PROBLEM: The present invention is the invention of the ionic liquid represented by the general formula [1]: wherein, R 1 to R 3 and n pieces of R 4 each independently represent hydrogen atom or alkyl group having 1 to 4 carbon atoms, R 5 to R 7 each independently represent alkyl group, aralkyl group, or aryl group, R 8 represents alkyl group, aralkyl group, aryl group, or the one represented by the general formula [2]: (wherein T represents alkylene chain having 1 to 8 carbon atoms, n represents 1 or 2, and R 1 to R 7 are the same as the above-described), X represents nitrogen atom or phosphorus atom, n represents 1 or 2. When n is 1, R 3 and R 4 are bound and may form cyclohexene ring together with the adjacent carbon atoms. In addition, when X is nitrogen atom, R 5 to R 7 or R 5 to R 6 may form hetero ring with nitrogen atom binding thereto}.

  问题：提供一种新型离子液体，成本低、环保，并具有低粘度和熔点。 解决问题的方法：本发明是一种由通式[1]表示的离子液体的发明：其中，R1到R3和n个R4分别独立表示氢原子或具有1到4个碳原子的烷基基团，R5到R7分别独立表示烷基基团、芳基烷基基团或芳基基团，R8表示烷基基团、芳基烷基基团、芳基基团或由通式[2]表示的基团：（其中T表示具有1到8个碳原子的烷基链，n表示1或2，R1到R7与上述相同），X表示氮原子或磷原子，n表示1或2。当n为1时，R3和R4结合并且可能与相邻碳原子一起形成环己烯环。此外，当X为氮原子时，R5到R7或R5到R6可能与结合在一起的氮原子形成杂环}。