4-[[2-Chloro-1-[(2a(2)-methyl[1,1a(2)-biphenyl]-4-yl)methyl]-1H-imidazol-5-yl]methyl]benzonitrile | 198204-65-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-[[2-Chloro-1-[(2a(2)-methyl[1,1a(2)-biphenyl]-4-yl)methyl]-1H-imidazol-5-yl]methyl]benzonitrile
• 英文别名: 4-[[2-chloro-3-[[4-(2-methylphenyl)phenyl]methyl]imidazol-4-yl]methyl]benzonitrile
• CAS: 198204-65-8
• 化学式: C₂₅H₂₀ClN₃
• 分子量: 397.9
• InChiKey: QQHXQTVIFYZMQK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.2
• 重原子数：
  29
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  41.6
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• Method of treating cancer
  申请人：Rosen Neal

  公开号：US20050137207A1

  公开（公告）日：2005-06-23

  The present invention relates to methods of treating cancer using a combination of a compound which is an antineoplastic agent and a compound which is a inhibitor of prenyl-protein transferase, which methods comprise administering to said mammal, either sequentially in any order or simultaneously, amounts of at least two therapeutic agents selected from a group consisting of a compound which is an antineoplastic agent and a compound which is a inhibitor of prenyl-protein transferase. The invention also relates to methods of preparing such compositions.

  本发明涉及使用一种抗肿瘤剂和一种前尼蛋白转移酶抑制剂的组合治疗癌症的方法，该方法包括向所述哺乳动物施用来自以下组中至少两种治疗剂的量，所述组包括一种抗肿瘤剂和一种前尼蛋白转移酶抑制剂，所述治疗剂可以按任何顺序依次或同时施用。该发明还涉及制备这种组合物的方法。
• INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE
  申请人：MERCK & CO., INC.

  公开号：EP0891333A1

  公开（公告）日：1999-01-20
• US6080870A
  申请人：——

  公开号：US6080870A

  公开（公告）日：2000-06-27
• US6989383B1
  申请人：——

  公开号：US6989383B1

  公开（公告）日：2006-01-24
• [EN] INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE<br/>[FR] INHIBITEURS DE LA FARNESYL-PROTEINE TRANSFERASE
  申请人：MERCK & CO., INC.

  公开号：WO1997036875A1

  公开（公告）日：1997-10-09

  (EN) The present invention is directed to compounds which inhibit farnesyl-protein transferase (FTase) and the farnesylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for inhibiting farnesyl-protein transferase and the farnesylation of the oncogene protein Ras.(FR) L'invention concerne des composés qui inhibent la farnésyl-protéine transférase (FTase) et la farnésylation de la protéine oncogène Ras. Elle concerne également des compositions chimiothérapiques contenant ces composés et des procédés permettant d'inhiber la farnésyl-protéine transférase, ainsi que la farnésylation de la protéine oncogène Ras.