(4-methanesulfonyl-phenyl)-[5-nitro-6-(4-phenylsulfanyl-piperidin-1-yl)-pyrimidin-4-yl]-amine | 733750-73-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (4-methanesulfonyl-phenyl)-[5-nitro-6-(4-phenylsulfanyl-piperidin-1-yl)-pyrimidin-4-yl]-amine
• 英文别名: N-(4-methylsulfonylphenyl)-5-nitro-6-(4-phenylsulfanylpiperidin-1-yl)pyrimidin-4-amine
• CAS: 733750-73-7
• 化学式: C₂₂H₂₃N₅O₄S₂
• 分子量: 485.588
• InChiKey: OEBKLOOOUYPCEF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.9
• 重原子数：
  33
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  155
• 氢给体数：
  1
• 氢受体数：
  9

文献信息

• TREATING PAIN, DIABETES, AND DISORDERS OF LIPID METABOLISM
  申请人：Harris M. Joel

  公开号：US20080070892A1

  公开（公告）日：2008-03-20

  Disclosed is a method of treating a disease or condition (e.g., pain, diabetes or disorders of lipid metabolism) comprising administering an azetidine derivative of the formula I selected from the group consisting of the compounds defined by Tables 1, 2, 3a, 3b, 3c, 3d and 4a.

  揭示了一种治疗疾病或病症（例如疼痛、糖尿病或脂质代谢紊乱）的方法，包括给予从表1、2、3a、3b、3c、3d和4a定义的化合物组中选择的式I的吖啶衍生物。
• Azetidinone Derivatives and Methods of Use Thereof
  申请人：Aslanian G. Robert

  公开号：US20080076750A1

  公开（公告）日：2008-03-27

  The present invention relates to methods for treating or preventing a disorder of lipid metabolism, pain, diabetes, a vascular condition, demyelination or nonalcoholic fatty liver disease, comprising administering a compound having the formula or a pharmaceutically acceptable salt, solvate, ester, prodrug or stereoisomer thereof, wherein: R 1 and R 2 are defined in Tables 1-6 herein, and R 3 is -phenyl, -4-chlorophenyl, -2-pyridyl, or -3-pyridyl.

  本发明涉及治疗或预防脂质代谢紊乱、疼痛、糖尿病、血管疾病、脱髓鞘或非酒精性脂肪肝病的方法，包括给予具有以下结构式的化合物或其药学上可接受的盐、溶剂化合物、酯、前药或立体异构体： R 1 和 R 2 在本文的表1-6中定义，并且 R 3 为-苯基、-4-氯苯基、-2-吡啶基或-3-吡啶基。
• [EN] 1,2,3-TRISUBSTITUTED ARYL AND HETEROARYL DERIVATIVES AS MODULATORS OF METABOLISM AND THE PRPPHYLAXIS AND TREATMENT OF DISORDERS RELATED THERETO SUCH AS DIABETES AND HYPERGLYCEMIA<br/>[FR] DERIVES ARYLES ET HETEROARYLES TRI-SUBSTITUES EN POSITION 1,2,3 EN TANT QUE MODULATEURS DE METABOLISME ET PROPHYLAXIE ET TRAITEMENT DE TROUBLES LIES AU METABOLISME
  申请人：ARENA PHARM INC

  公开号：WO2004065380A1

  公开（公告）日：2004-08-05

  The present invention relates to certain 1,2,3-trisubstituted aryl and heteroaryl derivatives of Fomula (Ia) that are modulators of metabolism. Accordingly, compounds of the present invention are useful in the prophylaxis or treatment of metabolic disorders and complications thereof, such as, diabetes and obesity.

  本发明涉及某些Fomula（Ia）的1,2,3-三取代芳基和杂芳基衍生物，它们是代谢调节剂。因此，本发明的化合物在预防或治疗代谢紊乱及其并发症，如糖尿病和肥胖方面是有用的。
• 1,2,3-Trisubstituted aryl and heteroaryl derivatives as modulators of metabolism and the prophylaxis and treatment of disorders related thereto such as diabetes and hyperglycemia
  申请人：Jones M. Robert

  公开号：US20060217379A1

  公开（公告）日：2006-09-28

  The present invention relates to certain 1,2,3-trisubstituted aryl and heteroaryl derivatives of Fomula (Ia) that are modulators of metabolism. Accordingly, compounds of the present invention are useful in the prophylaxis or treatment of metabolic disorders and complications thereof, such as, diabetes and obesity.

  本发明涉及某些1,2,3-三取代芳基和杂环芳基衍生物（Ia式）的代谢调节剂。因此，本发明的化合物在预防或治疗代谢性疾病及其并发症，如糖尿病和肥胖症方面是有用的。
• AZETIDINE DERIVATIVES USEFUL IN TREATING PAIN, DIABETES AND DISORDERS OF LIPID METABOLISM
  申请人：McKittrick A. Brian

  公开号：US20080089858A1

  公开（公告）日：2008-04-17

  Disclosed are compounds of the formula: and compounds of the formula: wherein R 1 , R 2 , R 3 , R 4 , R 5 , u and v are as defined herein. Also disclosed are methods of treating pain (e.g., inflammatory pain, chronic pain, and neuropathic pain), methods of treating diabetes, and methods of inhibiting the absorption of cholesterol using compounds of formula I or IIA.

  本发明涉及以下式的化合物：以及以下式的化合物：其中R1，R2，R3，R4，R5，u和v如本文所定义。本发明还涉及使用I或IIA式化合物治疗疼痛（例如，炎性疼痛，慢性疼痛和神经病理性疼痛）的方法，治疗糖尿病的方法以及抑制胆固醇吸收的方法。