布马地宗钙 | 34461-73-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 布马地宗钙
• CAS: 34461-73-9
• 化学式: C19H22CaN2O3
• 分子量: 366.5
• InChiKey: RZYRNMHFMODINJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.56
• 重原子数：
  25
• 可旋转键数：
  8
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.26
• 拓扑面积：
  69.6
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• US4301177A
  申请人：——

  公开号：US4301177A

  公开（公告）日：1981-11-17
• [EN] FORMULATION BASED ON MICRONIZED CLINOPTILOLITE AS THERAPEUTIC AGENT PROVIDING HIGHLY BIOAVAILABLE SILICON<br/>[FR] FORMULATION À BASE DE CLINOPTILOLITE MICRONISÉE UTILISÉE EN TANT QU'AGENT THÉRAPEUTIQUE PRODUISANT UN SILICIUM EXTRÊMEMENT BIODISPONIBLE
  申请人：NOVATECH D O O

  公开号：WO2010018418A1

  公开（公告）日：2010-02-18

  This invention relates to a formulation based on micronized clinoptilolite (MC) as therapeutic agent for effective release of highly bioavailable silicon. The formulation comprising variable portions of: (i) micronized clinoptilolite (MC) of general formula: (Men+)x/n[(AlO2)x(SiO2)y]-mH2O (MC) where Me= H, Li, Na, K, Mg, Ca, Zn, Ag, Cu, Mn, Fe; whereas ratio of silicon to aluminum, y:x is between 2.6:1 to 5: 1; number of crystalline water m is from 0 to 20, which is characterized by particles size from 500 nm to 5 μm; and of (ii) one or more excipients which yield in desired pharmaceutical form: tablets, capsules, ointments, creams, gels, lotions, shampoos, powders, liquid powders, compact powders, masks, suppositories, syrups, suspensions, soaps, and therapeutic patches; and of one or more pharmaceutical or cosmetic active substances which contribute and/or enhance basic biological actions of silicic acid. The use of the formulation provides all known positive therapeutic effects of highly bioavailable silicon: stimulation of immune system; treatment of allergic conditions; adjuvant terapy at microbial infections; increasing strength of blood vessels walls, and decreasing of their wall permeability; stimulation of joints and ligaments functions; stimulation of osteoblasts and bone mineralizations; prevention of osteoporosis; decreasing resorption of aluminum from gastrointestinal tract; improving structure of cartilage; antiinflammatory action at various acute or chronic inflammatory diseases; treatment of various skin diseases such as skin irritations, ekzema, seborrheic dermatitis, neurodermitis, atopic dermatitis, psoriasis; treatment of decubitus; treatment of wounds and burns; stimulation of biosynthesis of collagen and elastin; slowing down of skin ageing; reduction of wrinkles; stimulation of hair growth, strength, and brightness; and stimulation of nails growth and strength.
• [EN] FORMULATION BASED ON MICRONIZED ZEOLITE, GREEN TEA EXTRACT, AND GENISTEIN AS A THERAPEUTIC AGENT FOR REDUCTION OF BODY WEIGHT AND CELLULITE<br/>[FR] FORMULATION À BASE DE ZÉOLITHE MICRONISÉE, D'EXTRAIT DE THÉ VERT ET DE GÉNISTÉINE EN TANT QU'AGENT THÉRAPEUTIQUE POUR RÉDUIRE LE POIDS CORPOREL ET LA CELLULITE
  申请人：NOVATECH ISTRAZIVANJE D O O

  公开号：WO2010097643A1

  公开（公告）日：2010-09-02

  This invention relates to a pharmaceutical formulation based on variable portions of: (i) micronized zeolite (MZ) of general formula: (Men+) x/n[(AI02)x(Si02)y].mH20 (MZ) wherein Me= Na, K, Mg, Ca; whereas ratio of silicon to aluminum, y:x is between 6:1 to 1:1; number of crystalline water m is from 0 to 20, which is characterized by particles size < 5 μm; in concentrations from 1-50%, most preferably from 3-30%; (ii) Green tea extract containing at least 30% of epigallocatechin gallate (EGCG), and 5% of caffeine; in concentrations from 0.1-90%, most preferably from 20-90%; (iii) genistein; in concentrations from 0.05-20%, most preferably from 1-10%; and (iv) one or more excipients which yield in desired pharmaceutical or cosmetic form: tablets, capsules, ointments, creams, gels, lotions, shampoos, powders, liquid powders, syrups, suspensions, and therapeutic patches; in concentrations from 1-98.85%, most preferably from 10-75%; which is useful for highly effective reduction of body weight and cellulite.