{(2S,3R)-2-((E)-3,3-Dimethoxy-propenyl)-4-oxo-3-[2-(pyrrolidine-1-carbonyl)-benzoylamino]-azetidin-1-yl}-acetic acid tert-butyl ester | 135382-75-1

• 英文名称: {(2S,3R)-2-((E)-3,3-Dimethoxy-propenyl)-4-oxo-3-[2-(pyrrolidine-1-carbonyl)-benzoylamino]-azetidin-1-yl}-acetic acid tert-butyl ester
• CAS: 135382-75-1
• 化学式: C₂₆H₃₅N₃O₇
• 分子量: 501.58
• InChiKey: BWNKYKBSKJPRKN-JXXBKOHCSA-N

反应信息

• 作为产物：
  描述：

  四氢吡咯 、 [(2R,3S)-2-((E)-3,3-Dimethoxy-propenyl)-3-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-4-oxo-azetidin-1-yl]-acetic acid tert-butyl ester 以 四氢呋喃 为溶剂， 以90%的产率得到{(2S,3R)-2-((E)-3,3-Dimethoxy-propenyl)-4-oxo-3-[2-(pyrrolidine-1-carbonyl)-benzoylamino]-azetidin-1-yl}-acetic acid tert-butyl ester
  参考文献：
  名称：

  Scope of phthalimido chemistry I. Extension of utility by conversion to the opcb protecting group.

  摘要：

  The scope of the phthalimido protecting group (PhthN-) is extended with pyrrolidine. The resulting omicron-pyrrolidinocarbonylbenzamide (''OPCB-'') represents a base/nucleophile stable derivative of the parent, which reverts to the imide form upon treatment with acid. This methodology allows utilization of this protecting group (as the OPCB form) in synthetic sequences requiring basic/nucleophilic reaction conditions.

  DOI：

  10.1016/s0040-4039(00)92691-1